MRX complex nuclease subunit YMR224C (Q27553080)

Metallo-dependent phosphatase-like

1 reference

Mre11, DNA-binding domain superfamily

1 reference

Mre11, DNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Calcineurin-like phosphoesterase

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

manganese ion binding

1 reference

9 May 2019

molecular adaptor activity

4 references

14 February 2019

Complex formation and functional versatility of Mre11 of budding yeast in recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

14 February 2019

Complex formation and functional versatility of Mre11 of budding yeast in recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Complex formation and functional versatility of Mre11 of budding yeast in recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Complex formation and functional versatility of Mre11 of budding yeast in recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

double-stranded telomeric DNA binding

1 reference

9 May 2019

The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

telomeric DNA binding

single-stranded telomeric DNA binding

1 reference

9 May 2019

The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

adenylate kinase activity

1 reference

9 May 2019

Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

endonuclease activity

The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity

3 references

G-quadruplex DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

endodeoxyribonuclease activity

1 reference

9 May 2019

Saccharomyces cerevisiae Mre11 is a high-affinity G4 DNA-binding protein and a G-rich DNA-specific endonuclease: implications for replication of telomeric DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

10 references

9 May 2019

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Complex formation and functional versatility of Mre11 of budding yeast in recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Proteome-wide protein interaction measurements of bacterial proteins of unknown function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

3'-5'-exodeoxyribonuclease activity

IPI

5 references

10 September 2018

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

10 September 2018

The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

10 September 2018

DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

10 September 2018

Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

10 September 2018

Complex formation and functional versatility of Mre11 of budding yeast in recombination

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

single-stranded DNA endodeoxyribonuclease activity

EXP

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

double-stranded telomeric DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

endonuclease activity

4 references

10 September 2018

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

10 September 2018

The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

3'-5' exonuclease activity

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

single-stranded telomeric DNA binding

3'-5'-exodeoxyribonuclease activity

6 references

9 May 2019

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Complex formation and functional versatility of Mre11 of budding yeast in recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

4 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

7 November 2018

Complex formation and functional versatility of Mre11 of budding yeast in recombination

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

7 November 2018

Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

3 references

10 September 2018

Complex formation and functional versatility of Mre11 of budding yeast in recombination

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

site of double-strand break

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Complex formation and functional versatility of Mre11 of budding yeast in recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

meiotic DNA double-strand break processing

HDA

biological process

1 reference

9 May 2019

Meiotic chromosomes: it takes two to tango

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

double-strand break repair via nonhomologous end joining

TAS

mitotic intra-S DNA damage checkpoint signaling

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

DNA double-strand break processing involved in repair via synthesis-dependent strand annealing

1 reference

9 May 2019

Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

regulation of transcription involved in meiotic cell cycle

1 reference

9 May 2019

Mre11 mediates gene regulation in yeast spore development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

1 reference

9 May 2019

A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

mitochondrial double-strand break repair via homologous recombination

1 reference

5 June 2018

Mitochondrial genome maintenance: roles for nuclear nonhomologous end-joining proteins in Saccharomyces cerevisiae

SGD

S000004837

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

meiotic DNA double-strand break formation

1 reference

5 June 2018

Meiotic chromosomes: it takes two to tango

SGD

S000004837

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

reciprocal meiotic recombination

TAS

1 reference

9 May 2019

Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

cellular response to DNA damage stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

meiotic DNA double-strand break formation involved in reciprocal meiotic recombination

1 reference

9 May 2019

Functions of the yeast meiotic recombination genes, MRE11 and MRE2.

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

maintenance of DNA trinucleotide repeats

1 reference

9 May 2019

The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

nucleotide phosphorylation

1 reference

27 February 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

1 reference

5 June 2018

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

SGD

S000004837

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

nucleoside monophosphate phosphorylation

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

double-strand break repair

3 references

10 September 2018

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

sister chromatid cohesion

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

mitotic G2 DNA damage checkpoint signaling

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

telomeric 3' overhang formation

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829

double-strand break repair via homologous recombination

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

double-strand break repair via nonhomologous end joining

3 references

9 May 2019

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

A genomics-based screen for yeast mutants with an altered recombination/end-joining repair ratio.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829

1 reference

Calcineurin-like phosphoesterase domain, ApaH type

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference