Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2. (Q27934963)

Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control

GOA release 2020-03-11

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A G Hinnebusch

1

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language of work or name

English

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publication date

October 1993

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published in

Molecular Microbiology

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1 December 2016

10

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page(s)

215-23

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issue

2

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cites work

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https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Complex formation by positive and negative translational regulators of GCN4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

A second class of synthetase structure revealed by X-ray analysis of Escherichia coli seryl-tRNA synthetase at 2.5 A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Posttranscriptional regulatory mechanisms in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Molecular analysis of GCN3, a translational activator of GCN4: evidence for posttranslational control of GCN3 regulatory function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

GCD11, a negative regulator of GCN4 expression, encodes the gamma subunit of eIF-2 in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Multiple GCD genes required for repression of GCN4, a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Translational control in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Molecular characterization of GCD1, a yeast gene required for general control of amino acid biosynthesis and cell-cycle initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Evidence for translational regulation of the activator of general amino acid control in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

The war against the interferon-induced dsRNA-activated protein kinase: can viruses win?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

The scanning model for translation: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Sequences that surround the stop codons of upstream open reading frames in GCN4 mRNA determine their distinct functions in translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Multiple upstream AUG codons mediate translational control of GCN4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Initiation of protein synthesis in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Transcriptional-translational regulatory circuit in Saccharomyces cerevisiae which involves the GCN4 transcriptional activator and the GCN2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

5' untranslated sequences are required for the translational control of a yeast regulatory gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Multiple cis-acting elements modulate the translational efficiency of GCN4 mRNA in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

The leader peptide of yeast gene CPA1 is essential for the translational repression of its expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X

Mutations in the structural genes for eukaryotic initiation factors 2 alpha and 2 beta of Saccharomyces cerevisiae disrupt translational control of GCN4 mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.1993.TB01947.X