Serine/threonine-protein kinase GCN2 YDR283C (Q5529366)

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fungal protein found in Saccharomyces cerevisiae S288c

• AAS102
• NDR2
• AAS1
• GCN2
• general control nonderepressible 2
• YDR283C
• serine/threonine-protein kinase GCN2

edit

Language	Label	Description	Also known as
English	Serine/threonine-protein kinase GCN2 YDR283C	fungal protein found in Saccharomyces cerevisiae S288c	AAS102 NDR2 AAS1 GCN2 general control nonderepressible 2 YDR283C serine/threonine-protein kinase GCN2

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

P15442

subclass of

protein-coding gene

1 reference

stated in

Ensembl Release 87

Ensembl gene ID

YDR283C

part of

Protein kinase-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P15442

eIF-2-alpha kinase Gcn2

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P15442

Ubiquitin-conjugating enzyme/RWD-like

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P15442

Anticodon-binding domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P15442

Histidyl tRNA synthetase-related domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

RWD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

Crystall structure of the kinase gcn2.png
550 × 550; 94 KB

1 reference

imported from Wikimedia project

English Wikipedia

Wikimedia import URL

https://en.wikipedia.org/w/index.php?title=Gcn2&oldid=883871523

found in taxon

Saccharomyces cerevisiae S288c

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

P15442

encoded by

GCN2

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

P15442

molecular function

ATP binding

determination method

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

tRNA binding

determination method

IMP

IEA

IDA

4 references

retrieved

9 May 2019

stated in

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IMP

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

retrieved

9 May 2019

stated in

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

kinase activity

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

RNA binding

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

nucleotide binding

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

transferase activity

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

protein serine/threonine kinase activity

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

eukaryotic translation initiation factor 2alpha kinase activity

determination method

IEA

IDA

4 references

retrieved

27 March 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15442&geneProductId=UniProtKB:P15442

determination method

IEA

retrieved

27 March 2018

stated in

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15442&geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

27 March 2018

stated in

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15442&geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

27 March 2018

stated in

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15442&geneProductId=UniProtKB:P15442

determination method

IDA

double-stranded RNA binding

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

protein binding

determination method

IPI

5 references

retrieved

9 May 2019

stated in

Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IPI

retrieved

9 May 2019

stated in

Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IPI

retrieved

9 May 2019

stated in

Proteome survey reveals modularity of the yeast cell machinery

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IPI

retrieved

9 May 2019

stated in

A global protein kinase and phosphatase interaction network in yeast.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IPI

retrieved

9 May 2019

stated in

The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IPI

translation initiation factor binding

determination method

IPI

1 reference

retrieved

9 May 2019

stated in

Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IPI

protein homodimerization activity

determination method

IDA

2 references

retrieved

9 May 2019

stated in

Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

ribosome binding

determination method

IDA

3 references

retrieved

9 May 2019

stated in

Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

ribosomal large subunit binding

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

protein self-association

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

protein kinase activity

determination method

IDA

IEA

IMP

5 references

retrieved

27 March 2018

stated in

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15442&geneProductId=UniProtKB:P15442

determination method

IMP

retrieved

27 March 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15442&geneProductId=UniProtKB:P15442

determination method

IEA

retrieved

27 March 2018

stated in

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15442&geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

27 March 2018

stated in

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15442&geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

27 March 2018

stated in

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15442&geneProductId=UniProtKB:P15442

determination method

IDA

protein kinase activity

determination method

IBA

IDA

IEA

IMP

6 references

retrieved

9 May 2019

stated in

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IMP

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

retrieved

9 May 2019

stated in

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IBA

eukaryotic translation initiation factor 2alpha kinase activity

determination method

IBA

IDA

IEA

5 references

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

retrieved

9 May 2019

stated in

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IBA

cell component

cytosolic ribosome

determination method

IDA

1 reference

retrieved

27 March 2018

stated in

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15442&geneProductId=UniProtKB:P15442

determination method

IDA

cytoplasm

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

large ribosomal subunit

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

small ribosomal subunit

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

polysomal ribosome

determination method

IDA

2 references

retrieved

9 May 2019

stated in

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

cytosolic ribosome

determination method

IBA

IDA

2 references

retrieved

9 May 2019

stated in

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IBA

biological process

regulation of translational initiation by eIF2 alpha phosphorylation

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

DNA damage checkpoint signaling

determination method

IMP

IEA

2 references

retrieved

9 May 2019

stated in

Gcn2p regulates a G1/S cell cycle checkpoint in response to DNA damage

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IMP

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

regulation of translation

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

protein phosphorylation

determination method

IMP

IEA

IDA

7 references

retrieved

9 May 2019

stated in

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IMP

retrieved

9 May 2019

stated in

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IMP

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

retrieved

9 May 2019

stated in

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

protein autophosphorylation

determination method

IMP

IDA

4 references

retrieved

9 May 2019

stated in

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IMP

retrieved

9 May 2019

stated in

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

regulation of translational initiation

determination method

IDA

2 references

retrieved

9 May 2019

stated in

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2.

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

phosphorylation

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

protein biosynthesis

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IEA

cellular response to amino acid starvation

determination method

IDA

IMP

3 references

retrieved

9 May 2019

stated in

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IMP

retrieved

9 May 2019

stated in

Transcriptional-translational regulatory circuit in Saccharomyces cerevisiae which involves the GCN4 transcriptional activator and the GCN2 protein kinase

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

cellular response to hydrogen peroxide

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IMP

cellular response to histidine

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

positive regulation of translational initiation in response to starvation

determination method

IDA

IMP

3 references

retrieved

9 May 2019

stated in

GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IMP

retrieved

9 May 2019

stated in

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

retrieved

9 May 2019

stated in

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

cellular response to benomyl

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IMP

positive regulation of cellular response to amino acid starvation

determination method

IDA

IGI

IMP

4 references

retrieved

9 May 2019

stated in

Positive regulation in the general amino acid control of Saccharomyces cerevisiae

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IMP

retrieved

9 May 2019

stated in

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IMP

retrieved

9 May 2019

stated in

Positive regulation in the general amino acid control of Saccharomyces cerevisiae

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IGI

retrieved

9 May 2019

stated in

Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

cellular stress response to acidic pH

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

GOA

curator

UniProt

UniProt protein ID

P15442

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IMP

positive regulation of macroautophagy

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

negative regulation of protein kinase activity by protein phosphorylation

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IDA

negative regulation of TORC1 signaling

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

GOA

curator

SGD

Saccharomyces Genome Database ID

S000002691

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15442

determination method

IMP

has part(s)

RWD domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P15442

protein kinase domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P15442

Histidyl tRNA synthetase-related domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P15442

serine/threonine-protein kinase, active site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P15442

protein kinase, ATP binding site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P15442

Identifiers

RefSeq protein ID

NP_010569

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

851877

UniProt protein ID

P15442

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

P15442

Ensembl protein ID

YDR283C

1 reference

stated in

ensembl Release 106

Ensembl protein ID

YDR283C

Freebase ID

/m/0cn_nz2

0 references

Saccharomyces Genome Database ID

S000002691

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

851877

 

Sitelinks

Wikipedia(1 entry)

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• enwiki Gcn2

Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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