The SCFCdc4 ubiquitin ligase regulates calcineurin signaling through degradation of phosphorylated Rcn1, an inhibitor of calcineurin (Q27935806)

Serine/threonine/tyrosine protein kinase MCK1 YNL307C

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Tsutomu Kishi

1

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Akemi Ikeda

2

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Rina Nagao

3

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Noriko Koyama

Proceedings of the National Academy of Sciences of the United States of America

4

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language of work or name

English

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publication date

30 October 2007

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published in

1 reference

1 December 2016

104

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issue

44

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page(s)

17418-23

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cites work

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An essential function of Grr1 for the degradation of Cln2 is to act as a binding core that links Cln2 to Skp1.

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A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

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A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling

20 March 2017

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The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer

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Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo

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Calcineurin regulates bone formation by the osteoblast

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GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs

29 September 2017

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29 September 2017

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The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress.

29 September 2017

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Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo

29 September 2017

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Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans

29 September 2017

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Regulation of the p53 tumor suppressor protein

29 September 2017

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Regulation of the calmodulin-stimulated protein phosphatase, calcineurin

29 September 2017

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The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

29 September 2017

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Aggregate formation and synaptic abnormality induced by DSCR1.

21 January 2018

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Combined copy status of 18q21 genes in colorectal cancer shows frequent retention of SMAD7

27 November 2018

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