NFAT signaling: choreographing the social lives of cells (Q28216151)

Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells

Europe PubMed Central

title

NFAT signaling: choreographing the social lives of cells (English)

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author name string

Gerald R Crabtree

series ordinal

1

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Eric N Olson

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2

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language of work or name

English

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publication date

April 2002

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published in

Cell

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volume

109 Suppl

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page(s)

S67-79

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cites work

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Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo

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Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

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Calcineurin activity is only partially inhibited in leukocytes of cyclosporine-treated patients

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Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction

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Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3

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Calcium - a life and death signal

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Ca(2+)-dependent gene expression mediated by MEF2 transcription factors.

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Fiber-type-specific transcription of the troponin I slow gene is regulated by multiple elements

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Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA

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A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type

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Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4.

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Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

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Contingent genetic regulatory events in T lymphocyte activation

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Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

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Calcineurin inhibition ameliorates structural, contractile, and electrophysiologic consequences of postinfarction remodeling

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Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo

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7 January 2021

Calcineurin is required for skeletal muscle hypertrophy

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7 January 2021

Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation

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Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells

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An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy

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Gene regulation mediated by calcium signals in T lymphocytes

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Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

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Decoding calcium signals involved in cardiac growth and function

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Calsarcins, a novel family of sarcomeric calcineurin-binding proteins

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7 January 2021

A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart

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7 January 2021

Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons.

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7 January 2021

L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons

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7 January 2021

Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature

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7 January 2021

Evolutionary relationships among Rel domains indicate functional diversification by recombination

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7 January 2021

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

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7 January 2021

Intronic enhancer activity of the eosinophil-derived neurotoxin (RNS2) and eosinophil cationic protein (RNS3) genes is mediated by an NFAT-1 consensus binding sequence.

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7 January 2021

Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy

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7 January 2021

Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2

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7 January 2021

NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity

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7 January 2021

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

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7 January 2021

Altered primary myogenesis in NFATC3(-/-) mice leads to decreased muscle size in the adult

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7 January 2021

Human diseases: clues to cracking the connexin code?

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7 January 2021

The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells

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7 January 2021

Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells

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7 January 2021

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

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7 January 2021

Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein

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7 January 2021

Regulation of the calmodulin-stimulated protein phosphatase, calcineurin

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7 January 2021

Rapid targeting of nuclear proteins to the cytoplasm

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7 January 2021

Cain, a novel physiologic protein inhibitor of calcineurin

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7 January 2021

Calcineurin inhibition and cardiac hypertrophy: a matter of balance

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7 January 2021

Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein

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7 January 2021

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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7 January 2021

Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member

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7 January 2021

A viral mechanism for inhibition of the cellular phosphatase calcineurin.

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7 January 2021

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo.

1 reference

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7 January 2021

Glycogen synthase kinase-3 inhibits the DNA binding activity of NFATc

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

NF-AT components define a family of transcription factors targeted in T-cell activation

1 reference

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7 January 2021

Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

Calcineurin signaling and muscle remodeling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

The transcription factor NFAT4 is involved in the generation and survival of T cells

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

A second calcineurin binding site on the NFAT regulatory domain

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7 January 2021

NFATc1 and NFATc2 together control both T and B cell activation and differentiation

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

The signal for capacitative calcium entry

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7 January 2021

The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis

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7 January 2021

The transcription factor NF-ATc is essential for cardiac valve formation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc

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7 January 2021

Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

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7 January 2021

A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling

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7 January 2021

Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo

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7 January 2021

Calcineurin inhibitor attenuates left ventricular hypertrophy, leading to prevention of heart failure in hypertensive rats

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7 January 2021

Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway

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7 January 2021

Isolation of mutant T lymphocytes with defects in capacitative calcium entry

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7 January 2021

Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth

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7 January 2021

Identification of a putative regulator of early T cell activation genes

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7 January 2021

Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy

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7 January 2021

Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension

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7 January 2021

Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells

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7 January 2021

Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes

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7 January 2021

Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

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7 January 2021

Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

1 reference

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7 January 2021

Regulation of IL-4 production in mast cells: a paradigm for cell-type-specific gene expression

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7 January 2021

Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc

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7 January 2021

p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway

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7 January 2021

An enhanced immune response in mice lacking the transcription factor NFAT1.

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7 January 2021

Vascular-specific growth factors and blood vessel formation

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

CaT1 manifests the pore properties of the calcium-release-activated calcium channel

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

T cell responses in calcineurin A alpha-deficient mice

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7 January 2021

Solution structure of the core NFATC1/DNA complex

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7 January 2021

NF-AT activation requires suppression of Crm1-dependent export by calcineurin

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1

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7 January 2021

Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900699-2

7 January 2021

10.1016/S0092-8674(02)00699-2

Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

651639

651639

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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