Targeting Prefrontal Cortical Systems for Drug Development: Potential Therapies for Cognitive Disorders (Q28076907)

Crossref

Min Wang

series ordinal

2

1 reference

Crossref

language of work or name

1 reference

2016

1 reference

Annual Review of Pharmacology and Toxicology

published in

1 reference

volume

56

1 reference

page(s)

339-60

1 reference

Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses

cites work

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Autism spectrum disorders and schizophrenia: meta-analysis of the neural correlates of social cognition

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Alpha-2 adrenergic challenge with guanfacine one month after mild traumatic brain injury: altered working memory and BOLD response

20 March 2017

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Dynamic Network Connectivity: A new form of neuroplasticity

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Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress

20 March 2017

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Neuronal nicotinic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: focus on cognition

20 March 2017

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Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex

20 March 2017

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Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study

20 March 2017

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Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide

20 March 2017

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Regulation of NMDA receptor trafficking by amyloid-beta

20 March 2017

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PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence

20 March 2017

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The evolution of the brain, the human nature of cortical circuits, and intellectual creativity

20 March 2017

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Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

20 March 2017

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Development of cortical asymmetry in typically developing children and its disruption in attention-deficit/hyperactivity disorder.

20 March 2017

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A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC

20 March 2017

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Essential role for the PKC target MARCKS in maintaining dendritic spine morphology

20 March 2017

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Meeting of minds: the medial frontal cortex and social cognition

20 March 2017

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Deep brain stimulation for treatment-resistant depression

7 April 2017

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The Organization of Networks within the Orbital and Medial Prefrontal Cortex of Rats, Monkeys and Humans

7 April 2017

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Cellular basis of working memory

7 April 2017

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Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia

7 April 2017

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Dopamine's Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders

7 April 2017

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Chronic Stimulation of Alpha-2A-Adrenoceptors With Guanfacine Protects Rodent Prefrontal Cortex Dendritic Spines and Cognition From the Effects of Chronic Stress

29 September 2017

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Ameliorating treatment-refractory depression with intranasal ketamine: potential NMDA receptor actions in the pain circuitry representing mental anguish

29 September 2017

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Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder.

29 September 2017

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A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation

29 September 2017

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The Effects of Stress Exposure on Prefrontal Cortex: Translating Basic Research into Successful Treatments for Post-Traumatic Stress Disorder

29 September 2017

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Neural correlates of strategic reasoning during competitive games.

29 September 2017

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Progressive reduction in cortical thickness as psychosis develops: a multisite longitudinal neuroimaging study of youth at elevated clinical risk

29 September 2017

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Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey

29 September 2017

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Neural Substrates of Dopamine D2 Receptor Modulated Executive Functions in the Monkey Prefrontal Cortex

29 September 2017

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REDD1 is essential for stress-induced synaptic loss and depressive behavior

29 September 2017

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cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex

29 September 2017

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Rapid induction of REDD1 gene expression in macrophages in response to stress-related catecholamines

29 September 2017

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Do rats have prefrontal cortex? The rose-woolsey-akert program reconsidered

29 September 2017

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Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors

29 September 2017

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An open-label study of guanfacine extended release for traumatic stress related symptoms in children and adolescents.

29 September 2017

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Development of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficits

29 September 2017

1 reference

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Reciprocal regulation of PKA and Rac signaling

29 September 2017

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Norepinephrine modulates the motility of resting and activated microglia via different adrenergic receptors

29 September 2017

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Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: implications for schizophrenia

29 September 2017

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Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia.

29 September 2017

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Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices.

29 September 2017

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Constellation of HCN channels and cAMP regulating proteins in dendritic spines of the primate prefrontal cortex: potential substrate for working memory deficits in schizophrenia

29 September 2017

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The role of prefrontal dopamine D1 receptors in the neural mechanisms of associative learning.

29 September 2017

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Prefrontal contributions to metacognition in perceptual decision making

29 September 2017

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Lost in transition: aging-related changes in executive control by the medial prefrontal cortex

29 September 2017

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α7-Nicotinic receptors and cognition

29 September 2017

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Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings

29 September 2017

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Effects of α-2A adrenergic receptor agonist on time and risk preference in primates

29 September 2017

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Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations

29 September 2017

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Control of visual cortical signals by prefrontal dopamine

29 September 2017

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From Reactive to Proactive and Selective Control: Developing a Richer Model for Stopping Inappropriate Responses

29 September 2017

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Expression of the NR2B-NMDA receptor trafficking complex in prefrontal cortex from a group of elderly patients with schizophrenia.

29 September 2017

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Expression of the NR2B-NMDA receptor subunit and its Tbr-1/CINAP regulatory proteins in postmortem brain suggest altered receptor processing in schizophrenia

29 September 2017

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Possible influence of variant of the P-glycoprotein gene (MDR1/ABCB1) on clinical response to guanfacine in children with pervasive developmental disorders and hyperactivity

29 September 2017

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Targeting alpha7 nicotinic acetylcholine receptors in the treatment of schizophrenia

29 September 2017

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Differential regulation of alpha7 nicotinic receptor gene (CHRNA7) expression in schizophrenic smokers

29 September 2017

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Behavioral and neural changes after gains and losses of conditioned reinforcers.

29 September 2017

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Differential contributions of dopamine and serotonin to orbitofrontal cortex function in the marmoset.

29 September 2017

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A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis

29 September 2017

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Do thin spines learn to be mushroom spines that remember?

29 September 2017

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Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex.

29 September 2017

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Schizophrenia and the alpha7 nicotinic acetylcholine receptor

29 September 2017

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Pathophysiologically based treatment interventions in schizophrenia

29 September 2017

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Specializations of the granular prefrontal cortex of primates: implications for cognitive processing

29 September 2017

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Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions

29 September 2017

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Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early postnatal development.

29 September 2017

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Cortex, cognition and the cell: new insights into the pyramidal neuron and prefrontal function

29 September 2017

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Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study

29 September 2017

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Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for schizophrenia

29 September 2017

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Neuronal KCNQ potassium channels: physiology and role in disease.

29 September 2017

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Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness

29 September 2017

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Dissociating executive functions of the prefrontal cortex.

29 September 2017

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The contribution of alpha 2-noradrenergic mechanisms of prefrontal cortical cognitive function. Potential significance for attention-deficit hyperactivity disorder

29 September 2017

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Association of m1 and m2 muscarinic receptor proteins with asymmetric synapses in the primate cerebral cortex: morphological evidence for cholinergic modulation of excitatory neurotransmission

29 September 2017

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Staging of Alzheimer's disease-related neurofibrillary changes

29 September 2017

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Guanfacine treatment of comorbid attention-deficit hyperactivity disorder and Tourette's syndrome: preliminary clinical experience

29 September 2017

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Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease

29 September 2017

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Sleep and dreaming: induction and mediation of REM sleep by cholinergic mechanisms

29 September 2017

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Neurobiology of obsessive compulsive disorder

29 September 2017

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Multiple apparent alpha-noradrenergic receptor binding sites in rat brain: effect of 6-hydroxydopamine

29 September 2017

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Stress Impairs Prefrontal Cortical Function via D1 Dopamine Receptor Interactions With Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

29 September 2017

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The neurobiology of thought: the groundbreaking discoveries of Patricia Goldman-Rakic 1937-2003.

2 June 2018

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Selective deficit in no-go performance induced by blockade of prefrontal cortical alpha 2-adrenoceptors in monkeys

2 June 2018

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Pyramidal cells of the frontal lobe: all the more spinous to think with.

2 June 2018

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Subgenual prefrontal cortex abnormalities in mood disorders

2 June 2018

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Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory

2 June 2018

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An open trial of guanfacine in the treatment of attention-deficit hyperactivity disorder

2 June 2018

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Cerebral localization of emotion based on clinical-neuropathological correlations: methodological issues

2 June 2018

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Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex

2 June 2018

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The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes.

2 June 2018

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Neuronal activity related to saccadic eye movements in the monkey's dorsolateral prefrontal cortex

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Effects of ?2-adrenoceptor agonists on locus coeruleus firing rate and brain noradrenaline turnover in N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ)-treated rats

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Presynaptic inhibition by clonidine of neurotransmitter amino acid release in various brain regions

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

You'd better think twice: post-decision perceptual confidence

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Smoking improves divided attention in schizophrenia.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Guanfacine is an effective countermeasure for hypobaric hypoxia-induced cognitive decline

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Signaling mechanism underlying α2A -adrenergic suppression of excitatory synaptic transmission in the medial prefrontal cortex of rats

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Stimulation of α(2A)-adrenoceptors promotes the maturation of dendritic spines in cultured neurons of the medial prefrontal cortex

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

A randomized, double-blind, placebo-controlled study of guanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Functional magnetic resonance imaging evidence for a hierarchical organization of the prefrontal cortex

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Daytime prazosin reduces psychological distress to trauma specific cues in civilian trauma posttraumatic stress disorder

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Presynaptic mechanism underlying cAMP-induced synaptic potentiation in medial prefrontal cortex pyramidal neurons

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Locomotor hyperactivity induced by blockade of prefrontal cortical alpha2-adrenoceptors in monkeys

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Protein kinase C overactivity impairs prefrontal cortical regulation of working memory.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Pathology of layer V pyramidal neurons in the prefrontal cortex of patients with schizophrenia.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Selective D2 receptor actions on the functional circuitry of working memory

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Distribution of mGluR1alpha and mGluR5 immunolabeling in primate prefrontal cortex

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: stereologic analysis of prefrontal cortex area 9.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Effects of frontal lobe damage on interference effects in working memory

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Reduced communication between frontal and temporal lobes during talking in schizophrenia

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Local infusion of an alpha-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Alpha-2 adrenergic modulation of prefrontal cortical neuronal activity related to spatial working memory in monkeys

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

The reduced neuropil hypothesis: a circuit based model of schizophrenia

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

The alpha-2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Delayed-response deficit induced by local injection of the alpha 2-adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeys.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Abnormally high neuronal density in the schizophrenic cortex. A morphometric analysis of prefrontal area 9 and occipital area 17.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734124

A role for norepinephrine in stress-induced cognitive deficits: alpha-1-adrenoceptor mediation in the prefrontal cortex

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/26738476

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Intrinsic circuit organization of the major layers and sublayers of the dorsolateral prefrontal cortex in the rhesus monkey

1 reference

https://pubmed.ncbi.nlm.nih.gov/26738476

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/26738476

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1146/ANNUREV-PHARMTOX-010715-103617

0 references

1 reference

PubMed publication ID

26738476

1 reference