Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation (Q28088287)

Crossref

language of work or name

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July 2015

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1 July 2015

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11 October 2019

12 October 2019

19 January 2021

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11 October 2019

12 October 2019

19 January 2021

64

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page(s)

2369-75

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issue

7

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Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat

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EBF2 determines and maintains brown adipocyte identity

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PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1.

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PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program.

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Thermogenic activity of UCP1 in human white fat-derived beige adipocytes

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Ebf2 is a selective marker of brown and beige adipogenic precursor cells

29 September 2017

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A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation

29 September 2017

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Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.

29 September 2017

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EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex.

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PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders

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A multifunctional protein, EWS, is essential for early brown fat lineage determination

29 September 2017

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Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs

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MyomiR-133 regulates brown fat differentiation through Prdm16.

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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

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Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16.

29 September 2017

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Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

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Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]

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C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists

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p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene

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Early B-cell factor (O/E-1) is a promoter of adipogenesis and involved in control of genes important for terminal adipocyte differentiation.

29 September 2017

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Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level

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2 June 2018

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PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein.

2 June 2018

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27 November 2018

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27 November 2018

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27 November 2018

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27 November 2018

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27 November 2018

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27 November 2018

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2337/DB15-0203

1 reference

661175

661175

1 reference

1 reference

1 reference