Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging (Q28111789)

2

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K A Fenoglio

3

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B A Muggenburg

4

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C W Cotman

5

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P G Sullivan

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid

6

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language of work or name

English

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publication date

November 2009

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published in

Experimental Neurology

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volume

220

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issue

1

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page(s)

171-6

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cites work

1 reference

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Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites

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Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid

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29 September 2017

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Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation.

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Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity

29 September 2017

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Neuroprotection by the metabolic antioxidant alpha-lipoic acid

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The canine as an animal model of human aging and dementia

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Oxidative damage and mitochondrial decay in aging

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Carnitine function and requirements during the life cycle

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Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease

29 September 2017

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Visual-discrimination learning ability and beta-amyloid accumulation in the dog.

2 June 2018

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Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits.

2 June 2018

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Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks

2 June 2018

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Differences in lipid peroxidation and Cu,Zn-superoxide dismutase in the hippocampal CA1 region between adult and aged dogs

2 June 2018

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Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia.

27 November 2018

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Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease

27 November 2018

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Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs.

27 November 2018

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A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog.

27 November 2018

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Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study.

27 November 2018

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Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine.

27 November 2018

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Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study

27 November 2018

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Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease

27 November 2018

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The role of free radicals in canine counterpart of senile dementia of the Alzheimer type

27 November 2018

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Antioxidant vitamin intake and risk of Alzheimer disease

27 November 2018

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Dietary enrichment counteracts age-associated cognitive dysfunction in canines

27 November 2018

1 reference

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Oxidative damage increases with age in a canine model of human brain aging

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761532

Vitamin E and cognitive decline in older persons

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761532

Dietary intake of antioxidants and risk of Alzheimer disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761532

Immunohistochemical investigation of the brain of aged dogs. I. Detection of neurofibrillary tangles and of 4-hydroxynonenal protein, an oxidative damage product, in senile plaques

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761532

Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761532

Association of vitamin E and C supplement use with cognitive function and dementia in elderly men.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761532

Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761532

(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761532

Chronic antioxidant treatment improves the cognitive performance of aged rats.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761532

The effects of aging on hematology and serum chemistry values in the beagle dog

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19703441

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dietary supplement creatine protects against traumatic brain injury

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19703441

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19703441

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.EXPNEUROL.2009.08.014

1 reference

1 reference

1 reference

PubMed publication ID

19703441

1 reference