The Zika virus methyltransferase: structure and functions for drug design perspectives (Q28114691)

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scientific article (publication date: 28 December 2016)

Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives

Language	Label	Description	Also known as
English	The Zika virus methyltransferase: structure and functions for drug design perspectives	scientific article (publication date: 28 December 2016)	Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives

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scholarly article

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The Zika virus methyltransferase: structure and functions for drug design perspectives (English)

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1

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Jean-Jacques Vasseur

9

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Etienne Decroly

object named as

Etienne Decroly

12

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11

object named as

Bruno Canard

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Jean-Claude Guillemot

10

object named as

Jean Claude Guillemot

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author name string

Karine Barral

2

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Julie Lichière

3

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Barbara Selisko

4

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Baptiste Martin

5

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Wahiba Aouadi

6

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Miguel Ortiz Lombardia

7

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Françoise Debart

8

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language of work or name

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inferred from title

publication date

28 December 2016

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Journal of Virology

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91

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JVI.02202-16

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5

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on focus list of Wikimedia project

WikiProject Zika Corpus

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Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design

1 reference

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20 March 2017

Structures of NS5 Methyltransferase from Zika Virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

Zika virus in Brazil and macular atrophy in a child with microcephaly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

Potential sexual transmission of Zika virus

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20 March 2017

Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

Crystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

Rational design of a live attenuated dengue vaccine: 2'-o-methyltransferase mutants are highly attenuated and immunogenic in mice and macaques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

Data processing and analysis with the autoPROC toolbox

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20 March 2017

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

Features and development of Coot

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20 March 2017

1 reference

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20 March 2017

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

Structure of the methyltransferase domain from the Modoc virus, a flavivirus with no known vector

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

Phasercrystallographic software

1 reference

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20 March 2017

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

Structure and Function of Flavivirus NS5 Methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

West Nile Virus 5'-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2'-O Methylations by Nonstructural Protein 5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

20 March 2017

Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study

1 reference

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7 April 2017

How good are my data and what is the resolution?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

7 April 2017

Zika Virus Disease Cases - 50 States and the District of Columbia, January 1-July 31, 2016.

1 reference

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29 September 2017

Twenty years on: the impact of fragments on drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.

1 reference

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29 September 2017

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.

1 reference

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29 September 2017

The dengue virus NS5 protein as a target for drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

Rational design of a flavivirus vaccine by abolishing viral RNA 2'-O methylation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

The viral RNA capping machinery as a target for antiviral drugs

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

Designing cyclopentapeptide inhibitor as potential antiviral drug for dengue virus ns5 methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

Conventional and unconventional mechanisms for capping viral mRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

Biochemical and genetic characterization of dengue virus methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

Biochemical characterization of the (nucleoside-2'O)-methyltransferase activity of dengue virus protein NS5 using purified capped RNA oligonucleotides (7Me)GpppAC(n) and GpppAC(n).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

5′-Terminal 7-methylguanosine in eukaryotic mRNA is required for translation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

29 September 2017

Enhanced fold recognition using efficient short fragment clustering

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

2 June 2018

Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N⁷)-methyl transferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

2 June 2018

A base-labile group for 2'-OH protection of ribonucleosides: a major challenge for RNA synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

2 June 2018

Efficient Solid-Phase Chemical Synthesis of 5′-Triphosphates of DNA, RNA, and their Analogues

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309936

27 November 2018

Identifiers

10.1128/JVI.02202-16

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