The viral RNA capping machinery as a target for antiviral drugs (Q38030233)

27 August 2017

The viral RNA capping machinery as a target for antiviral drugs (English)

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27 August 2017

François Ferron

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Etienne Decroly

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Etienne Decroly

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2

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Bruno Canard

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4

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Bruno Canard

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27 August 2017

Barbara Selisko

3

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27 August 2017

26 July 2012

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27 August 2017

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27 August 2017

96

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27 August 2017

1

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27 August 2017

21-31

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Induction and regulation of IFNs during viral infections

27 August 2017

1 reference

12 December 2020

2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members

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12 December 2020

Deciphering the molecular basis for nucleotide selection by the West Nile virus RNA helicase

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12 December 2020

The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core.

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12 December 2020

Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis.

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12 December 2020

Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domain

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12 December 2020

Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid

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12 December 2020

Inhibition of vaccinia mRNA methylation by 2',5'-linked oligo(adenylic acid) triphosphate

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12 December 2020

The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase

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12 December 2020

Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase

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12 December 2020

Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus

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12 December 2020

West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism

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12 December 2020

Sindbis virus mutants resistant to mycophenolic acid and ribavirin

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12 December 2020

Antiviral effect of catechins in green tea on influenza virus

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12 December 2020

Innate immune response to viral infection

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12 December 2020

Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle

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12 December 2020

A conserved domain of yeast RNA triphosphatase flanking the catalytic core regulates self-association and interaction with the guanylyltransferase component of the mRNA capping apparatus

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12 December 2020

Kinetic and thermodynamic characterization of the RNA guanylyltransferase reaction

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12 December 2020

The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA.

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12 December 2020

Structure, mechanism, and evolution of the mRNA capping apparatus

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12 December 2020

Flavivirus methyltransferase: a novel antiviral target

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12 December 2020

Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication

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12 December 2020

What messenger RNA capping tells us about eukaryotic evolution.

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12 December 2020

Bluetongue virus VP4 is an RNA-capping assembly line

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12 December 2020

The broad spectrum antiviral nucleoside ribavirin as a substrate for a viral RNA capping enzyme.

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12 December 2020

Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts

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12 December 2020

Alternate capping mechanisms for transcription of spring viremia of carp virus: evidence for independent mRNA initiation.

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12 December 2020

Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid

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12 December 2020

A protein binding the methylated 5'-terminal sequence, m7GpppN, of eukaryotic messenger RNA

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12 December 2020

Hendra and nipah infection: pathology, models and potential therapies

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12 December 2020

West Nile Virus 5'-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2'-O Methylations by Nonstructural Protein 5

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12 December 2020

The 5′ terminal structure of the methylated mRNA synthesized in vitro by vesicular stomatitis virus

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12 December 2020

Flavivirus RNA cap methyltransferase: structure, function, and inhibition

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12 December 2020

Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme

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12 December 2020

The RNA capping machinery as an anti-infective target

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12 December 2020

Inhibition of vaccinia RNA guanine 7-methyltransferase by compounds designed as multisubstrate adducts

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12 December 2020

Processing the message: structural insights into capping and decapping mRNA.

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12 December 2020

Reaction in alphavirus mRNA capping: formation of a covalent complex of nonstructural protein nsP1 with 7-methyl-GMP.

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12 December 2020

The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure

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12 December 2020

Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

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12 December 2020

Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

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12 December 2020

Molecular mapping of the RNA Cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16.

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12 December 2020

Guanosine nucleotide analogs as inhibitors of alphavirus mRNA capping enzyme

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12 December 2020

Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus

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12 December 2020

Globin mRNAs are primers for the transcription of influenza viral RNA in vitro

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12 December 2020

Nucleotide analogs and molecular modeling studies reveal key interactions involved in substrate recognition by the yeast RNA triphosphatase

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12 December 2020

Novel initiation of RNA synthesis in vitro by vesicular stomatitis virus

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12 December 2020

Depletion of GTP pool is not the predominant mechanism by which ribavirin exerts its antiviral effect on Lassa virus

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12 December 2020

Biochemical characterization of the (nucleoside-2'O)-methyltransferase activity of dengue virus protein NS5 using purified capped RNA oligonucleotides (7Me)GpppAC(n) and GpppAC(n).

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12 December 2020

Recognition of viruses by cytoplasmic sensors

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12 December 2020

Putative RNA capping activities encoded by brome mosaic virus: methylation and covalent binding of guanylate by replicase protein 1a

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12 December 2020

Critical residues of Semliki Forest virus RNA capping enzyme involved in methyltransferase and guanylyltransferase-like activities

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12 December 2020

Dengue virus utilizes a novel strategy for translation initiation when cap-dependent translation is inhibited

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12 December 2020

The Caenorhabditis elegans mRNA 5'-capping enzyme. In vitro and in vivo characterization

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12 December 2020

Characterization of the AdoMet-dependent guanylyltransferase activity that is associated with the N terminus of bamboo mosaic virus replicase

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12 December 2020

Ribavirin causes error catastrophe during Hantaan virus replication.

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12 December 2020

Virus-specific mRNA capping enzyme encoded by hepatitis E virus

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12 December 2020

Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition

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12 December 2020

Pharmacologic advances in the treatment and prevention of respiratory syncytial virus

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12 December 2020

Re-capping the message

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12 December 2020

The anti-yellow fever virus activity of ribavirin is independent of error-prone replication

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12 December 2020

Structural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl-transferase

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12 December 2020

Di-and trimethylated congeners of 7-methylguanine in Sindbis virus mRNA

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12 December 2020

Structural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus Methyltransferase

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12 December 2020

Histidine triad-like motif of the rotavirus NSP2 octamer mediates both RTPase and NTPase activities

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12 December 2020

Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5

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12 December 2020

Cap-snatching mechanism in yeast L-A double-stranded RNA virus

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12 December 2020

Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription

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12 December 2020

Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex

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12 December 2020

In vitro reconstitution of SARS-coronavirus mRNA cap methylation

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12 December 2020

Transcription units for mRNA production in eukaryotic cells and their DNA viruses

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12 December 2020

Conventional and unconventional mechanisms for capping viral mRNA.

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12 December 2020

Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds

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12 December 2020

An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

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12 December 2020

YM-53403, a unique anti-respiratory syncytial virus agent with a novel mechanism of action

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12 December 2020

Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation

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12 December 2020

Mutations that confer resistance to mycophenolic acid and ribavirin on sindbis virus map to the nonstructural protein nsP1

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12 December 2020

The 5′-termini of heterogeneous nuclear RNA: a comparison among molecules of different sizes and ages

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12 December 2020

The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription

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12 December 2020

Atomic model of a cypovirus built from cryo-EM structure provides insight into the mechanism of mRNA capping

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12 December 2020

Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives

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12 December 2020

Protein tyrosine phosphatases: mechanisms of catalysis and regulation

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12 December 2020

A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses.

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12 December 2020

Recognition of viruses by innate immunity.

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12 December 2020

Virus-specific capping of tobacco mosaic virus RNA: methylation of GTP prior to formation of covalent complex p126-m7GMP.

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12 December 2020

The HR motif in the RNA-dependent RNA polymerase L protein of Chandipura virus is required for unconventional mRNA-capping activity.

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12 December 2020

Noncytolytic control of viral infections by the innate and adaptive immune response

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12 December 2020

The DEAD-box protein family of RNA helicases

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12 December 2020

A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.

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12 December 2020

Unconventional mechanism of mRNA capping by the RNA-dependent RNA polymerase of vesicular stomatitis virus.

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12 December 2020

Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models

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12 December 2020

A high-throughput screening assay for the identification of flavivirus NS5 capping enzyme GTP-binding inhibitors: implications for antiviral drug development

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12 December 2020

Additional methylation at the N(2)-position of the cap of 26S Semliki Forest virus late mRNA and initiation of translation

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12 December 2020

Rotavirus protein involved in genome replication and packaging exhibits a HIT-like fold

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12 December 2020

In vitro and in vivo studies of ribavirin action on Brazilian Orthobunyavirus.

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12 December 2020

The structure of the 5' terminal cap of the respiratory syncytial virus mRNA.

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12 December 2020

Identification of a Novel Function of theAlphavirusCapping Apparatus

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12 December 2020

Structure of the host-derived sequences present at the 5' ends of influenza virus mRNA.

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12 December 2020

Transfer of 5′-terminal cap of globin mRNA to influenza viral complementary RNA during transcription in vitro

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12 December 2020

Structure and Function of Flavivirus NS5 Methyltransferase

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12 December 2020

SnRNAs, SnRNPs, and RNA Processing

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12 December 2020

Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target

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12 December 2020

10.1016/J.ANTIVIRAL.2012.07.007

Identifiers

DOI

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27 August 2017

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PubMed ID

22841701