NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity (Q28115755)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

meta-analysis

0 references

title

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity (English)

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

GOA release 2020-03-11

nucleoside phosphate catabolic process

1 reference

GOA release 2020-03-11

author

Takaya Moriyama

1

1 reference

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8 March 2020

Xujie Zhao

6

1 reference

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8 March 2020

Keito Hoshitsuki

8

1 reference

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8 March 2020

Ute Hofmann

11

1 reference

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8 March 2020

Motohiro Kato

13

1 reference

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8 March 2020

Tomoya Isobe

19

1 reference

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8 March 2020

Deepa Bhojwani

22

1 reference

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8 March 2020

Jun J Yang

34

1 reference

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8 March 2020

28

Mary V Relling

1 reference

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8 March 2020

29

Atsushi Manabe

2 references

3 January 2017

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8 March 2020

2

Rina Nishii

2 references

3 January 2017

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8 March 2020

Virginia Pérez-Andreu

3

object named as

Virginia Perez-Andreu

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

Federico Antillon Klussmann

8 March 2020

5

object named as

Federico Antillon Klussmann

2 references

3 January 2017

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8 March 2020

7

Ting-Nien Lin

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

9

Jacob Nersting

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

10

Kentaro Kihira

2 references

3 January 2017

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8 March 2020

12

Yoshihiro Komada

2 references

3 January 2017

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8 March 2020

14

Robert McCorkle

2 references

3 January 2017

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8 March 2020

16

Katsuyoshi Koh

2 references

3 January 2017

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8 March 2020

17

Cesar Rolando Najera

2 references

3 January 2017

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8 March 2020

18

Shirley Kow-Yin Kham

2 references

3 January 2017

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8 March 2020

Edwynn Kean-Hui Chiew

21

object named as

Edwynn Kean-Hui Chiew

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

author name string

Wenjian Yang

4

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Lie Li

15

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Zhiwei Chen

20

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Cynthia Jeffries

23

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Yan Lu

24

2 references

3 January 2017

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8 March 2020

Matthias Schwab

25

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Hiroto Inaba

26

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Hiroki Hori

30

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Ching-Hon Pui

27

1 reference

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8 March 2020

Kjeld Schmiegelow

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Allen E J Yeoh

32

1 reference

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8 March 2020

William E Evans

33

1 reference

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8 March 2020

language of work or name

English

0 references

publication date

15 February 2016

1 reference

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8 March 2020

2 references

3 January 2017

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8 March 2020

volume

48

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

page(s)

367-373

1 reference

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8 March 2020

issue

4

2 references

3 January 2017

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Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2

8 March 2020

cites work

1 reference

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Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians

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Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity

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Mercaptopurine/Methotrexate maintenance therapy of childhood acute lymphoblastic leukemia: clinical facts and fiction

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Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.

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A New Statistical Method for Haplotype Reconstruction from Population Data

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Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

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Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells

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Drug Insight: pharmacology and toxicity of thiopurine therapy in patients with IBD

20 March 2017

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Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial

20 March 2017

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Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

20 March 2017

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Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children

20 March 2017

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Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia

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Toxicity and response to thiopurines in patients with inflammatory bowel disease

29 September 2017

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Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia

29 September 2017

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A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

29 September 2017

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Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases.

29 September 2017

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Biology, risk stratification, and therapy of pediatric acute leukemias: an update

29 September 2017

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29 September 2017

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29 September 2017

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Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

29 September 2017

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Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer

29 September 2017

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Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing

29 September 2017

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Azathioprine: old drug, new actions

29 September 2017

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A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucl

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD.

29 September 2017

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Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia

2 June 2018

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A re-evaluation of random-effects meta-analysis.

2 June 2018

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Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine.

2 June 2018

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Systemic exposure to mercaptopurine as a prognostic factor in acute lymphocytic leukemia in children.

2 June 2018

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Thiopurine S-methyltransferase pharmacogenetics in childhood acute lymphoblastic leukemia.

2 June 2018

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Incorporation of 6-thioguanine nucleotides into DNA during maintenance therapy of childhood acute lymphoblastic leukemia-the influence of thiopurine methyltransferase genotypes

27 November 2018

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Treatment reduction for children and young adults with low-risk acute lymphoblastic leukaemia defined by minimal residual disease (UKALL 2003): a randomised controlled trial.

27 November 2018

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Minimal residual disease-guided treatment deintensification for children with acute lymphoblastic leukemia: results from the Malaysia-Singapore acute lymphoblastic leukemia 2003 study.

27 November 2018

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Simultaneous quantification of eleven thiopurine nucleotides by liquid chromatography-tandem mass spectrometry.

27 November 2018

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Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn's disease with endoscopic recurrence: efficacy and safety results of a randomised, double-blind, double-dummy, multicentre trial

27 November 2018

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DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma

27 November 2018

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Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold

27 November 2018

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Thiopurine S-methyltransferase activity in three major Asian populations: a population-based study in Singapore.

27 November 2018

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Adverse events leading to modification of therapy in a large cohort of patients with inflammatory bowel disease.

27 November 2018

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Thiopurine methyltransferase in acute lymphoblastic leukemia.

27 November 2018

1 reference

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Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment

27 November 2018

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Side effects of azathioprine in patients with Crohn's disease

27 November 2018

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Msh2 deficiency attenuates but does not abolish thiopurine hematopoietic toxicity in msh2-/- mice

27 November 2018

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Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5029084

Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia.

27 November 2018

1 reference

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Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5029084

Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia

27 November 2018

1 reference

12 December 2020

Duration and intensity of maintenance chemotherapy in acute lymphoblastic leukaemia: overview of 42 trials involving 12 000 randomised children

1 reference

12 December 2020

Liquid chromatography-tandem mass spectrometry quantification of 6-thioguanine in DNA using endogenous guanine as internal standard

1 reference

12 December 2020

Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease

1 reference

12 December 2020

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

1 reference

12 December 2020

The seventh international childhood acute lymphoblastic leukemia workshop report: Palermo, Italy, January 29--30, 2005

1 reference

12 December 2020

Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia

1 reference

12 December 2020

Identifiers

DOI

10.1038/NG.3508

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878724%20AND%20SRC:MED&resulttype=core&format=json