The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram (Q28115926)

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English	The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram	scientific journal article

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scholarly article

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4 January 2017

The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram (English)

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4 January 2017

Phosphodiesterase 4A

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GOA release 2020-03-11

signal transduction

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GOA release 2020-03-11

author name string

E. Huston

1

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4 January 2017

L. Pooley

2

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4 January 2017

P. Julien

3

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4 January 2017

G. Scotland

4

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4 January 2017

I. McPhee

5

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4 January 2017

M. Sullivan

6

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4 January 2017

G. Bolger

7

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4 January 2017

M. D. Houslay

8

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4 January 2017

language of work or name

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publication date

6 December 1996

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4 January 2017

Journal of Biological Chemistry

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4 January 2017

271

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4 January 2017

49

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4 January 2017

31334–31344

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4 January 2017

Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes

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Diversity in cyclic nucleotide phosphodiesterase isoenzyme families

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Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function

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Regulation of intracellular cyclic AMP concentrations in hepatocytes involves the integrated activation and desensitization of adenylyl cyclase coupled with the action and activation of specific isoforms of cyclic AMP phosphodiesterase

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The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors

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Purification and characterization of high-affinity cyclic adenosine monophosphate phosphodiesterase from dog kidney

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A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes

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Purification and properties of the insulin-stimulated cyclic AMP phosphodiesterase from rat liver plasma membranes

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Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene

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Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes

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Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase

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Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C).

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Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)

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Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

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Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse

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Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4

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Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

1 reference

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Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum

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Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase

1 reference

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Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

1 reference

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Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8.

1 reference

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Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)

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Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: 'designer' changes in Vmax, stability and membrane association.

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Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex

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The determination of enzyme inhibitor constants

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A kinetic evaluation of monoamine oxidase activity in rat liver mitochondrial outer membranes

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[3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1.

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Stereospecific binding of the antidepressant rolipram to brain protein structures

1 reference

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Mutational analysis of phosphodiesterase in Drosophila.

1 reference

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Characterization of two human cAMP-specific phosphodiesterase subtypes expressed in baculovirus-infected insect cells

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Microtubules in the Cytoplasm of an Amoeba

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Identifiers

10.1074/JBC.271.49.31334

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1 reference

4 January 2017

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