Phosphodiesterase 4A (Q21117805)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

PDE4A
DPDE2
phosphodiesterase E2 dunce homolog, Drosophila
PDE46
phosphodiesterase 4A, cAMP-specific (dunce
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
phosphodiesterase isozyme 4

Language	Label	Description	Also known as
English	Phosphodiesterase 4A	mammalian protein found in Homo sapiens	PDE4A DPDE2 phosphodiesterase E2 dunce homolog, Drosophila PDE46 phosphodiesterase 4A, cAMP-specific (dunce cAMP-specific 3',5'-cyclic phosphodiesterase 4A phosphodiesterase isozyme 4

Statements

1 reference

13 November 2019

UniProt protein ID

3'5'-cyclic nucleotide phosphodiesterase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P27815

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P27815

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HD/PDEase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

phosphoric diester hydrolase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

determination method

1 reference

5 June 2018

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

determination method

protein binding

determination method

1 reference

5 June 2018

Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

3',5'-cyclic-nucleotide phosphodiesterase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

3',5'-cyclic-AMP phosphodiesterase activity

determination method

5 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

determination method

5 June 2018

Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

determination method

5 June 2018

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

determination method

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

determination method

5 June 2018

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

determination method

3',5'-cyclic-AMP phosphodiesterase activity

determination method

5 references

8 April 2019

Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

8 April 2019

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

8 April 2019

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

protein binding

determination method

determination method

ruffle membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

cell projection

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

determination method

3 references

8 April 2019

Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

determination method

perinuclear region of cytoplasm

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

8 April 2019

Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

biological process

sensory perception of smell

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

regulation of cAMP-mediated signaling

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

cAMP catabolic process

determination method

5 references

31 October 2017

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

determination method

31 October 2017

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

determination method

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

determination method

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

determination method

31 October 2017

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

determination method

regulation of protein kinase A signaling

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

cAMP catabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

determination method

physically interacts with

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1752

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL484785

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL19449

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL332750

flavoxate hydrochloride

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200875

3'5'-cyclic nucleotide phosphodiesterase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P27815

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P27815

HD/PDEase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P27815

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000293683

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000293683

ENSP00000341007

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000341007

ENSP00000370078

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370078

ENSP00000394754

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000394754

ENSP00000468507

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468507

ENSP00000465792

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465792

ENSP00000467137

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000467137

PDB structure ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21117805&oldid=2022971209"