Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma (Q28117269)

positive regulation of production of miRNAs involved in gene silencing by miRNA

GOA release 2020-03-11

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GOA release 2020-03-11

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Katleen De Preter

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Jo Vandesompele

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Alexander Schramm

object named as

Alexander Schramm

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Filip Pattyn

object named as

Filip Pattyn

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Frank Speleman

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object named as

Frank Speleman

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4 January 2017

Sara De Brouwer

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4 January 2017

Pieter Mestdagh

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4 January 2017

Irina Lambertz

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4 January 2017

Frank Westermann

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4 January 2017

Christina Schroeder

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4 January 2017

Johannes H. Schulte

International Journal of Cancer

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4 January 2017

language of work or name

English

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publication date

1 June 2012

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130

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2591–2598

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Recent advances in neuroblastoma

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MYCN oncoprotein targets and their therapeutic potential

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Function and regulation of the transcription factors of the Myc/Max/Mad network

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Targeted expression of MYCN causes neuroblastoma in transgenic mice

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MYCN regulates oncogenic MicroRNAs in neuroblastoma

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The MYCN enigma: significance of MYCN expression in neuroblastoma

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Combined IFN-gamma and retinoic acid treatment targets the N-Myc/Max/Mad1 network resulting in repression of N-Myc target genes in MYCN-amplified neuroblastoma cells

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Retinoic acid decreases targeting of p27 for degradation via an N-myc-dependent decrease in p27 phosphorylation and an N-myc-independent decrease in Skp2.

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MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells.

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Use of RNA interference to elucidate the effect of MYCN on cell cycle in neuroblastoma

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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

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Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

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A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.

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Cell cycle regulation targets of MYCN identified by gene expression microarrays

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Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

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Secreted antagonists of the Wnt signalling pathway

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Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling

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Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling

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Dickkopf-3 expression is a marker for neuroblastic tumor maturation and is down-regulated by MYCN.

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MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3.

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Reduced expression of the REIC/Dkk-3 gene by promoter-hypermethylation in human tumor cells

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Functional epigenomics identifies genes frequently silenced in prostate cancer

21 January 2018

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Adenovirus-mediated overexpression of REIC/Dkk-3 selectively induces apoptosis in human prostate cancer cells through activation of c-Jun-NH2-kinase

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Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway

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Regulation of prostate cell growth and morphogenesis by Dickkopf-3.

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Expression of Dickkopf genes is strongly reduced in malignant melanoma

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Decreased expression of REIC/Dkk-3 in human renal clear cell carcinoma

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A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines

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MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors.

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The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma

21 January 2018

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RTPrimerDB: the portal for real-time PCR primers and probes

21 January 2018

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Wnt/beta-catenin signaling in development and disease

21 January 2018

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Molecular architecture of the DNA replication origin activation checkpoint

21 January 2018

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