The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma. (Q33756262)

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7 January 2020

title

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma (English)

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7 January 2020

4

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7 January 2020

Andrea Pession

6

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7 January 2020

author name string

Andrew Slack

1

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7 January 2020

Zaowen Chen

2

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7 January 2020

Roberto Tonelli

3

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7 January 2020

Lisa Hunt

5

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7 January 2020

Jason M Shohet

7

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7 January 2020

language of work or name

English

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publication date

11 January 2005

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7 January 2020

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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7 January 2020

volume

102

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7 January 2020

issue

3

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7 January 2020

page(s)

731-736

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Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification.

7 January 2020

cites work

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MYCN in neuronal tumours

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MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

21 June 2018

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21 June 2018

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Targeted inhibition of NMYC by peptide nucleic acid in N-myc amplified human neuroblastoma cells: cell-cycle inhibition with induction of neuronal cell differentiation and apoptosis.

21 June 2018

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p53-independent functions of MDM2.

21 June 2018

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Posttranslational modification of MDM2

21 June 2018

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Cell cycle regulatory functions of the human oncoprotein MDM2.

21 June 2018

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The MDM2-p53 interaction.

21 June 2018

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 June 2018

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21 June 2018

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21 June 2018

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The requirement for evasion of programmed cell death in neuroblastomas with MYCN amplification

21 June 2018

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21 June 2018

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Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis

21 June 2018

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Characterizing transcription factor binding sites using formaldehyde crosslinking and immunoprecipitation

21 June 2018

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Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation

21 June 2018

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ARF differentially modulates apoptosis induced by E2F1 and Myc.

21 June 2018

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Retinoblastoma protein transcriptional repression through histone deacetylation of a single nucleosome

21 June 2018

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Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

21 June 2018

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Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

21 June 2018

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Bax accelerates tumorigenesis in p53-deficient mice

21 June 2018

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Direct recruitment of N-myc to target gene promoters

21 June 2018

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The Myc/Max/Mad network and the transcriptional control of cell behavior

21 June 2018

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MDM2--master regulator of the p53 tumor suppressor protein

21 June 2018

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

21 June 2018

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Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group

21 June 2018

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MYC oncogenes and human neoplastic disease

21 June 2018

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21 June 2018

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21 June 2018

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Targeted expression of MYCN causes neuroblastoma in transgenic mice

21 June 2018

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Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.

21 June 2018

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A functional p53-responsive intronic promoter is contained within the human mdm2 gene

21 June 2018

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21 June 2018

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Augmented MYCN expression advances the malignant phenotype of human neuroblastoma cells: evidence for induction of autocrine growth factor activity

21 June 2018

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21 June 2018

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Enhanced MYCN oncogene expression in human neuroblastoma cells is associated with altered FGF receptor expression and cellular growth response to basic FGF.

21 June 2018

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p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells.

21 June 2018

1 reference

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p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect.

30 October 2018

1 reference

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Role of two upstream open reading frames in the translational control of oncogene mdm2.

30 October 2018

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Down-regulation of endothelial cell growth inhibitors by enhanced MYCN oncogene expression in human neuroblastoma cells.

30 October 2018

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Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis

30 October 2018

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12 December 2020

Gene targeting using peptide nucleic acid

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12 December 2020

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

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12 December 2020

Absence of p53 gene mutations in primary neuroblastomas

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12 December 2020

Low frequency of the p53 gene mutations in neuroblastoma

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0405495102

1 reference

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7 January 2020

0 references

1 reference

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7 January 2020

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