Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors (Q28118868)

YES proto-oncogene 1, Src family tyrosine kinase

1 reference

SRC proto-oncogene, non-receptor tyrosine kinase

1 reference

LCK proto-oncogene, Src family tyrosine kinase

1 reference

FYN proto-oncogene, Src family tyrosine kinase

1 reference

protein tyrosine kinase activity

1 reference

Journal of Biological Chemistry

author name string

Toshiyuki Araki

series ordinal

1

1 reference

4 January 2017

Hiroyuki Nawa

series ordinal

2

1 reference

4 January 2017

Benjamin G. Neel

series ordinal

3

1 reference

4 January 2017

language of work or name

English

0 references

publication date

24 October 2003

1 reference

4 January 2017

1 reference

4 January 2017

278

1 reference

4 January 2017

43

1 reference

4 January 2017

41677–41684

1 reference

4 January 2017

Signaling--2000 and beyond

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Mitogen-activated protein kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Organization and regulation of mitogen-activated protein kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Protein tyrosine phosphatases in signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Combinatorial control of the specificity of protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Genetic analysis of protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Shp-2 tyrosine phosphatase: signaling one cell or many

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Mutational analysis of the SRC homology 2 domain protein-tyrosine phosphatase Corkscrew

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Cell signaling by receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Src family tyrosine kinases and growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Src family kinases are required for integrin but not PDGFR signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

New insights into the regulation and functions of Tec family tyrosine kinases in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

Two mechanisms activate PTPalpha during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200

A phosphotyrosine displacement mechanism for activation of Src by PTPalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306461200