Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis. (Q48346669)

http://europepmc.org/abstract/MED/9822738

10 February 2018

title

Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6793279&resulttype=core&format=json

12 May 2020

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early-onset autosomal dominant Alzheimer disease

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S Bursztajn

1

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R DeSouza

2

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D L McPhie

3

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S A Berman

4

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J Shioi

5

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N K Robakis

6

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R L Neve

7

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12 May 2020

language of work or name

English

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publication date

1 December 1998

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http://europepmc.org/abstract/MED/9822738

10 February 2018

published in

Journal of Neuroscience

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12 May 2020

volume

18

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issue

23

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page(s)

9790-9799

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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

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cites work

1 reference

12 December 2020

Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators

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12 December 2020

DNA fragmentation during apoptosis is caused by frequent single-strand cuts

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12 December 2020

Identification of a transitional preapoptotic population of thymocytes

1 reference

12 December 2020

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

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12 December 2020

A simple and rapid method for detection of apoptosis in human cells

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12 December 2020

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

12 December 2020

Expression of the Alzheimer amyloid precursor gene transcripts in the human brain.

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12 December 2020

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

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12 December 2020

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression.

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12 December 2020

A biochemical hallmark of apoptosis: internucleosomal degradation of the genome

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12 December 2020

Sensitization to morphine induced by viral-mediated gene transfer

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12 December 2020

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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12 December 2020

Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells

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12 December 2020

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

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12 December 2020

Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells.

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12 December 2020

APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein

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12 December 2020

Separate pools of endonuclease activity are responsible for internucleosomal and high molecular mass DNA fragmentation during apoptosis.

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12 December 2020

Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype

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12 December 2020

Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer's disease.

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12 December 2020

The presenilin genes: a new gene family involved in Alzheimer disease pathology

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12 December 2020

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12 December 2020

Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer.

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12 December 2020

G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

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12 December 2020

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease.

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12 December 2020

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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12 December 2020

G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.

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12 December 2020

Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I).

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12 December 2020

Apoptosis in the pathogenesis and treatment of disease

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12 December 2020

DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures.

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12 December 2020

A non-radioactive, sensitive method for the detection of DNA fragmentation in apoptotic cells (rat pheochromocytoma PC12 and rat cortical cells)

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12 December 2020

Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains.

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12 December 2020

Presence of double-strand breaks with single-base 3' overhangs in cells undergoing apoptosis but not necrosis

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12 December 2020

Morphological and biochemical characterization and analysis of apoptosis

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12 December 2020

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

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12 December 2020

Acetylcholine receptor clusters are associated with nuclei in rat myotubes

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12 December 2020

Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.

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12 December 2020

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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12 December 2020

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

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12 December 2020

10.1523/JNEUROSCI.18-23-09790.1998

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6793279&resulttype=core&format=json

12 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6793279&resulttype=core&format=json

12 May 2020

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