Paxillin and focal adhesion signalling (Q28142041)

Focal adhesions, contractility, and signaling

Europe PubMed Central

title

Paxillin and focal adhesion signalling (English)

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author name string

C E Turner

series ordinal

1

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language of work or name

English

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publication date

December 2000

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published in

Nature Cell Biology

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volume

2

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issue

12

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page(s)

E231-6

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cites work

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7 January 2021

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7 January 2021

Interactions between mitogenic stimuli, or, a thousand and one connections

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7 January 2021

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors

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7 January 2021

Integrins: emerging paradigms of signal transduction

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7 January 2021

Complexity and specificity of integrin signalling.

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7 January 2021

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Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins

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7 January 2021

Paxillin LD motifs may define a new family of protein recognition domains

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7 January 2021

Leupaxin is a novel LIM domain protein that forms a complex with PYK2

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7 January 2021

Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix

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7 January 2021

Identification of a series of transforming growth factor beta-responsive genes by retrovirus-mediated gene trap screening

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7 January 2021

Signaling through scaffold, anchoring, and adaptor proteins

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7 January 2021

The enigma of LIM domains

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7 January 2021

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding

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7 January 2021

Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses

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7 January 2021

Cell migration: a physically integrated molecular process

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7 January 2021

Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts

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7 January 2021

Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin

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7 January 2021

Intact LIM 3 and LIM 4 domains of paxillin are required for the association to a novel polyproline region (Pro 2) of protein-tyrosine phosphatase-PEST

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7 January 2021

Inhibitory tyrosine protein kinase p50csk is associated with protein-tyrosine phosphatase PTP-PEST in hemopoietic and non-hemopoietic cells

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7 January 2021

Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src

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7 January 2021

Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin

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7 January 2021

Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton

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7 January 2021

The tyrosine kinase PYK-2/RAFTK regulates natural killer (NK) cell cytotoxic response, and is translocated and activated upon specific target cell recognition and killing

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7 January 2021

Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

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Microtubule targeting of substrate contacts promotes their relaxation and dissociation

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7 January 2021

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly

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7 January 2021

pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk

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7 January 2021

Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase

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7 January 2021

Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation

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7 January 2021

Physiological signals and oncogenesis mediated through Crk family adapter proteins

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7 January 2021

Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells

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7 January 2021

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

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7 January 2021

Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis

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7 January 2021

The noncatalytic domain of protein-tyrosine phosphatase-PEST targets paxillin for dephosphorylation in vivo

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7 January 2021

Csk suppression of Src involves movement of Csk to sites of Src activity

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7 January 2021

Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport

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7 January 2021

Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin

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7 January 2021

Integrin alpha v beta 5-dependent serine phosphorylation of paxillin in cultured human macrophages adherent to vitronectin.

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7 January 2021

Activin A and TGF-beta stimulate phosphorylation of focal adhesion proteins and cytoskeletal reorganization in rat aortic smooth muscle cells

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7 January 2021

Mitosis specific serine phosphorylation and downregulation of one of the focal adhesion protein, paxillin.

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p21-activated protein kinase: a crucial component of morphological signaling?

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Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4 thymoma cells

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7 January 2021

Quantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal

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Serine/threonine protein phosphatases

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7 January 2021

A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation

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7 January 2021

Focal adhesions - the cytoskeletal connection

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7 January 2021

Signaling through focal adhesion kinase

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7 January 2021

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK

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7 January 2021

The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.

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7 January 2021

The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase

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7 January 2021

Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif

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7 January 2021

Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion

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7 January 2021

Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

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Rho GTPases and the actin cytoskeleton

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PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

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7 January 2021

Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation

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7 January 2021

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

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7 January 2021

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

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7 January 2021

ARF: a key regulatory switch in membrane traffic and organelle structure

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7 January 2021

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements

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7 January 2021

ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts

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7 January 2021

GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6

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7 January 2021

ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.

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7 January 2021

The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton

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7 January 2021

Identification of a new Pyk2 target protein with Arf-GAP activity

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7 January 2021

A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration

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7 January 2021

Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. Evidence for a role of paxillin in c-Jun NH(2)-terminal kinase activation

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7 January 2021