Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains (Q28143960)

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M Maratrat

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V Sierra

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E Conseiller

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L Debussche

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

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language of work or name

English

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publication date

8 April 1999

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published in

Oncogene

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volume

18

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page(s)

2405-10

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issue

14

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cites work

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p53 in signaling checkpoint arrest or apoptosis

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Induction of the growth inhibitor IGF-binding protein 3 by p53

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p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

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Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity

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Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein

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p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

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High-resolution structure of the oligomerization domain of p53 by multidimensional NMR

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CTS1: a p53-derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties

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Critical structural elements of the VP16 transcriptional activation domain

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Definition of a consensus binding site for p53

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A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

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A transcriptionally active DNA-binding site for human p53 protein complexes

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p53 in growth control and neoplasia

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p53; from inductive signal to cellular effect

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Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

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Mdm2 promotes the rapid degradation of p53

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p53 mutations in human cancers

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A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

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Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

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p53: puzzle and paradigm

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Regulation of p53 stability by Mdm2

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p53, the cellular gatekeeper for growth and division

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

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Human TAFII31 protein is a transcriptional coactivator of the p53 protein

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Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

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Wild-type p53 negatively regulates the expression of a microtubule-associated protein

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Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

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The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

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A model for p53-induced apoptosis

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Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

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p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

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The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

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Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

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7 January 2021

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

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7 January 2021

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

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7 January 2021

Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.

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Identification of a novel p53 functional domain that is necessary for mediating apoptosis

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