CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival (Q28183470)

https://api.crossref.org/works/10.1074/JBC.M305838200

31 March 2024

main subject

phosphorylation

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protein ubiquitination

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https://api.crossref.org/works/10.1074/JBC.M305838200

31 March 2024

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https://api.crossref.org/works/10.1074/JBC.M305838200

31 March 2024

3

Steven P Gygi

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Kenneth S. Kosik

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object named as

Kenneth S Kosik

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Hideki Shimura

1

object named as

Hideki Shimura

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author name string

Daniel Schwartz

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language of work or name

English

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publication date

6 February 2004

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10 November 2003

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Europe PubMed Central

PubMed publication ID

14612456

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612456

full work available at URL

31 March 2024

http://www.jbc.org/article/S0021925820750763/pdf

file format

Portable Document Format

online access status

open access

1 reference

Europe PubMed Central

PubMed publication ID

14612456

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612456

https://api.elsevier.com/content/article/PII:S0021925820750763?httpAccept=text/xml

31 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M305838200

https://api.elsevier.com/content/article/PII:S0021925820750763?httpAccept=text/plain

31 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M305838200

https://syndication.highwire.org/content/doi/10.1074/jbc.M305838200

31 March 2024

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https://api.crossref.org/works/10.1074/JBC.M305838200

Journal of Biological Chemistry

31 March 2024

published in

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volume

279

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issue

6

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page(s)

4869-76

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cites work

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Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

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Cdk5 is a key factor in tau aggregation and tangle formation in vivo

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Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

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Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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Altered proteasomal function in sporadic Parkinson's disease

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Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death.

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Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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Epitopes that span the tau molecule are shared with paired helical filaments.

21 January 2018

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A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

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Competition for microtubule-binding with dual expression of tau missense and splice isoforms

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Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain

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Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies

21 January 2018

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Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

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Proline-directed and non-proline-directed phosphorylation of PHF-tau.

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The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

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CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

21 January 2018

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Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

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The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

21 January 2018

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ErbB2 degradation mediated by the co-chaperone protein CHIP

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Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling

21 January 2018

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CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein

21 January 2018

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Chaperones increase association of tau protein with microtubules

21 January 2018

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Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

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General aspects of neurodegeneration.

21 January 2018

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Tau protein in normal and Alzheimer's disease brain.

31 March 2024

4

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Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease.

31 March 2024

6

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Tau epitopes are incorporated into a range of lesions in Alzheimer's disease

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22

1 reference

https://api.crossref.org/works/10.1074/JBC.M305838200

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

31 March 2024

24

1 reference

https://api.crossref.org/works/10.1074/JBC.M305838200

Rapid dephosphorylation of tau in heat-shocked fetal rat cerebral explants: prevention and hyperphosphorylation by inhibitors of protein phosphatases PP1 and PP2A

31 March 2024

30

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https://api.crossref.org/works/10.1074/JBC.M305838200

31 March 2024

Identifiers

1 reference

Consolidated OpenCitations Corpus – April 2017

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Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/nrdxr6jgkrd4djlpv7w3xlykmi

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

14612456

1 reference

Consolidated OpenCitations Corpus – April 2017