Cdk5 is a key factor in tau aggregation and tangle formation in vivo. (Q48300530)

10 February 2018

title

Cdk5 is a key factor in tau aggregation and tangle formation in vivo. (English)

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10 February 2018

author

Wendy Noble

1

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10 February 2018

Dennis W. Dickson

15

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10 February 2018

Mark P Burns

object named as

Mark Burns

12

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author name string

Vicki Olm

2

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10 February 2018

Kazuyuki Takata

3

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10 February 2018

Evelyn Casey

4

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10 February 2018

O Mary

5

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10 February 2018

Jordana Meyerson

6

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10 February 2018

Kate Gaynor

7

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10 February 2018

John LaFrancois

8

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10 February 2018

Lili Wang

9

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10 February 2018

Takayuki Kondo

10

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10 February 2018

Peter Davies

11

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10 February 2018

Veeranna

13

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10 February 2018

Ralph Nixon

14

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10 February 2018

Yasuji Matsuoka

16

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10 February 2018

Michael Ahlijanian

17

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10 February 2018

Lit-Fui Lau

18

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10 February 2018

Karen Duff

19

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10 February 2018

language of work or name

English

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publication date

1 May 2003

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10 February 2018

published in

Neuron

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10 February 2018

volume

38

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10 February 2018

issue

4

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10 February 2018

page(s)

555-565

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10 February 2018

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

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Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

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7 January 2021

A Cdk5-p35 stable complex is involved in the beta-amyloid-induced deregulation of Cdk5 activity in hippocampal neurons

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Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

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Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

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7 January 2021

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice.

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7 January 2021

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

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7 January 2021

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

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7 January 2021

Silver impregnation of Alzheimer's neurofibrillary changes counterstained for basophilic material and lipofuscin pigment.

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7 January 2021

Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model.

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Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes

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7 January 2021

Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants

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7 January 2021

Structure of tau protein and assembly into paired helical filaments

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7 January 2021

Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice

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7 January 2021

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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7 January 2021

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

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7 January 2021

Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease.

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7 January 2021

Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

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7 January 2021

Analysis of phosphorylation of tau with antibodies specific for phosphorylation sites

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7 January 2021

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

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7 January 2021

Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.

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7 January 2021

Neurotoxicity induces cleavage of p35 to p25 by calpain

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7 January 2021

A brain-specific activator of cyclin-dependent kinase 5.

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7 January 2021

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

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7 January 2021

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

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7 January 2021

Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta

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7 January 2021

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

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7 January 2021

Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry

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7 January 2021

Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells

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7 January 2021

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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7 January 2021

Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain.

1 reference

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7 January 2021

Direct interaction of soluble human recombinant tau protein with Abeta 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II.

1 reference

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7 January 2021

A role for cyclin-dependent kinase(s) in the modulation of fast anterograde axonal transport: effects defined by olomoucine and the APC tumor suppressor protein

1 reference

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7 January 2021

Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900259-9

7 January 2021

Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900259-9

7 January 2021

Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.

1 reference

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7 January 2021

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

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7 January 2021

Abeta amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice.

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7 January 2021

p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro

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7 January 2021

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900259-9

7 January 2021

m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900259-9

7 January 2021

Inhibition of neuronal cyclin-dependent kinase-5 by staurosporine and purine analogs is independent of activation by Munc-18.

1 reference

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7 January 2021

Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900259-9

7 January 2021

Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900259-9

7 January 2021

Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900259-9

7 January 2021

10.1016/S0896-6273(03)00259-9

Identifiers

DOI

1 reference

10 February 2018

PubMed ID

12765608

1 reference

10 February 2018