Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand (Q28190690)

4

object named as

Michel C Nussenzweig

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author name string

Almudena R Ramiro

1

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Pete Stavropoulos

2

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Mila Jankovic

Switch circular DNA formed in cytokine-treated mouse splenocytes: evidence for intramolecular DNA deletion in immunoglobulin class switching

3

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language of work or name

English

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publication date

May 2003

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published in

Nature Immunology

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volume

4

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issue

5

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page(s)

452-6

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cites work

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7 January 2021

Circular DNA is excised by immunoglobulin class switch recombination

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7 January 2021

Circular DNA is a product of the immunoglobulin class switch rearrangement

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7 January 2021

The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.

1 reference

7 January 2021

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

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7 January 2021

Ku80 is required for immunoglobulin isotype switching

1 reference

7 January 2021

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

1 reference

7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

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7 January 2021

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

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7 January 2021

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

1 reference

7 January 2021

Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

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7 January 2021

AID is essential for immunoglobulin V gene conversion in a cultured B cell line

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7 January 2021

The AID enzyme induces class switch recombination in fibroblasts

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7 January 2021

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

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7 January 2021

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

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7 January 2021

Molecular cloning of an apolipoprotein B messenger RNA editing protein

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7 January 2021

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

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7 January 2021

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

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7 January 2021

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

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7 January 2021

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

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7 January 2021

Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.

1 reference

7 January 2021

The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

1 reference

7 January 2021

Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

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7 January 2021

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

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7 January 2021

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

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7 January 2021

Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

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7 January 2021

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

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7 January 2021

Somatic hypermutation in the heavy chain locus correlates with transcription

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7 January 2021

Immunoglobulin class switching

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7 January 2021

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

1 reference

7 January 2021

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1 reference

7 January 2021

Shutdown of class switch recombination by deletion of a switch region control element.

1 reference

7 January 2021

Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination

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7 January 2021

Quantitative regulation of class switch recombination by switch region transcription

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7 January 2021

Increased transcription levels induce higher mutation rates in a hypermutating cell line

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7 January 2021

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

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7 January 2021

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

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7 January 2021

Effects of rare codon clusters on high-level expression of heterologous proteins in Escherichia coli

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7 January 2021

Transcription-induced mutations: increase in C to T mutations in the nontranscribed strand during transcription in Escherichia coli

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7 January 2021

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

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7 January 2021

Distribution of mutations around rearranged heavy-chain antibody variable-region genes

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7 January 2021

Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

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7 January 2021

Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer

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7 January 2021

Immunoglobulin genes: generating diversity with AID and UNG.

1 reference

7 January 2021

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

1 reference

7 January 2021

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

1 reference

7 January 2021

Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

1 reference

7 January 2021

Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro

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7 January 2021

A structural model of transcription elongation

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7 January 2021

Bacterial RNA polymerase

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7 January 2021

Nuclease cleavage of the upstream half of the nontemplate strand DNA in an Escherichia coli transcription elongation complex causes upstream translocation and transcriptional arrest.

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7 January 2021

The transcriptional regulator RfaH stimulates RNA chain synthesis after recruitment to elongation complexes by the exposed nontemplate DNA strand.

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7 January 2021

Transcription attenuation associated with bacterial repetitive extragenic BIME elements.

1 reference

7 January 2021