Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. (Q54608320)

1 June 2018

title

Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. (English)

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1 June 2018

author

Francisco Lozano

4

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author name string

Yélamos J

1

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1 June 2018

Klix N

2

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1 June 2018

Goyenechea B

3

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Chui YL

5

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1 June 2018

González Fernández A

6

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Pannell R

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Neuberger MS

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Milstein C

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language of work or name

English

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publication date

1 July 1995

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1 June 2018

published in

Nature

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1 June 2018

volume

376

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issue

6537

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1 June 2018

page(s)

225-229

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1 June 2018

https://scigraph.springernature.com/pub.10.1038/376225a0

exact match

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cites work

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

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Maturation of the immune response in germinal centers

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Intraclonal generation of antibody mutants in germinal centres

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Maturation and dispersal of B-cell clones during T cell-dependent antibody responses

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Analysis of somatic mutation in five B cell subsets of human tonsil

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Clusters of point mutations are found exclusively around rearranged antibody variable genes

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7 January 2021

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

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7 January 2021

Distribution of mutations around rearranged heavy-chain antibody variable-region genes

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7 January 2021

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions

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7 January 2021

Somatic mutation in constant regions of mouse lambda 1 light chains

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7 January 2021

Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice.

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7 January 2021

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.

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7 January 2021

Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma.

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7 January 2021

Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes

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7 January 2021

Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism

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7 January 2021

Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer

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7 January 2021

Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing.

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7 January 2021

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

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7 January 2021

Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes

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The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron.

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Mutation drift and repertoire shift in the maturation of the immune response

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Affinity maturation leads to differential expression of multiple copies of a κ light-chain transgene

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Stepwise intraclonal maturation of antibody affinity through somatic hypermutation

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Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

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7 January 2021

Somatic hypermutation in 5' flanking regions of heavy chain antibody variable regions.

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7 January 2021

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots

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7 January 2021

Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes

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A reporter gene to analyse the hypermutation of immunoglobulin genes.

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Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

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Defining the nucleic acid substrate for somatic hypermutation

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Somatic hypermutation

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Cellular selection leads to age-dependent and reversible down-regulation of transgenic immunoglobulin light chain genes

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1 Preparation of monoclonal antibodies: Strategies and procedures

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'Sticky feet'-directed mutagenesis and its application to swapping antibody domains

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Identifiers

DOI

10.1038/376225A0

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1 June 2018

Dimensions Publication ID

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1 June 2018