Melatonin: reducing the toxicity and increasing the efficacy of drugs (Q28194026)

Europe PubMed Central

title

Melatonin: reducing the toxicity and increasing the efficacy of drugs (English)

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Juan C Mayo

4

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Rosa María Sainz

Rosa M Sainz

3

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Russel J Reiter

1

Russel J Reiter

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Dun-Xian Tan

2

Dun-Xian Tan

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Silvia Lopez-Burillo

5

Journal of Pharmacy and Pharmacology

Silvia Lopez-Burillo

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language of work or name

English

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publication date

October 2002

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published in

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volume

54

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page(s)

1299-321

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issue

10

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cites work

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Melatonin enhances tamoxifen's ability to prevent the reduction in microsomal membrane fluidity induced by lipid peroxidation

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Correlation between nuclear melatonin receptor expression and enhanced cytokine production in human lymphocytic and monocytic cell lines

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Melatonin-immune system relationships

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Melatonin, a pineal secretory product with antioxidant properties, protects against cisplatin-induced nephrotoxicity in rats.

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Induction of DNA crosslinks and DNA strand lesions by cyclophosphamide after activation by cytochrome P450 2B1.

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Melatonin prevents oxidative stress resulting from iron and erythropoietin administration

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Free radicals and the heart

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Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status

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Ototoxicity caused by aminoglycosides is ameliorated by melatonin without interfering with the antibiotic capacity of the drugs

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Ototoxicity caused by cisplatin is ameliorated by melatonin and other antioxidants.

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Poor response to treatment of renal anaemia with erythropoietin corrected by iron given intravenously

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The immunotherapeutic potential of melatonin

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A unifying hypothesis for the mechanism of NSAID related gastrointestinal toxicity

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Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria

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Maternal pinealectomy abolishes the diurnal rhythm in plasma melatonin concentrations in the fetal sheep and pregnant ewe during late gestation

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Melatonin, a pineal hormone with antioxidant property, protects against adriamycin cardiomyopathy in rats

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Melatonin and its precursors scavenge nitric oxide

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Melatonin stimulates glutathione peroxidase activity in human chorion

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The protective action of melatonin on indomethacin-induced gastric and testicular oxidative stress in rats

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Melatonin administration prevents the nephrotoxicity induced by gentamicin

21 January 2018

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Effects of melatonin, morphine and diazepam on formalin-induced nociception in mice

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Melatonin: a peroxyl radical scavenger more effective than vitamin E.

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Melatonin-A Highly Potent Endogenous Radical Scavenger and Electron Donor: New Aspects of the Oxidation Chemistry of this Indole Accessed in vitroa

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Melatonin's unique radical scavenging properties - roles of its functional substituents as revealed by a comparison with its structural analogs

21 January 2018

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Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin.

21 January 2018

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Mechanism of cisplatin ototoxicity: antioxidant system.

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Melatonin protects the heart against both ischemia/reperfusion injury and chemotherapeutic drugs

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Melatonin receptors: molecular biology of a new family of G protein-coupled receptors

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Mechanism of protection by diethyldithiocarbamate against cisplatin ototoxicity: antioxidant system.

21 January 2018

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Polyunsaturated fatty acids, melatonin, and cancer prevention

21 January 2018

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Melatonin protects against gentamicin-induced nephrotoxicity in rats

21 January 2018

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Melatonin treatment for tardive dyskinesia: a double-blind, placebo-controlled, crossover study

21 January 2018

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Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat

21 January 2018

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Potent protective effect of melatonin on chromium(VI)-induced DNA single-strand breaks, cytotoxicity, and lipid peroxidation in primary cultures of rat hepatocytes

21 January 2018

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High physiological levels of melatonin in the bile of mammals

21 January 2018

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Significance of melatonin in antioxidative defense system: reactions and products

21 January 2018

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Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger.

21 January 2018

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Effects of long-term, low-dose, time-specified melatonin administration on endocrine and cardiovascular variables in adult men.

21 January 2018

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Melatonin protects human red blood cells from oxidative hemolysis: new insights into the radical-scavenging activity.

21 January 2018

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Melatonin enters the cerebrospinal fluid through the pineal recess

21 January 2018

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Nitrosation of melatonin by nitric oxide: a computational study.

21 January 2018

1 reference

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Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells

21 January 2018

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Melatonin in plant organs

21 January 2018

1 reference

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Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F002235702760345374

Melatonin protects against ischemia and reperfusion-induced oxidative lipid and DNA damage in fetal rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F002235702760345374

Melatonin protects fetal rat brain against oxidative mitochondrial damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F002235702760345374

Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats

21 January 2018

1 reference

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The effects of exogenous melatonin on endocrine function in man.

21 January 2018

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Effects by doxorubicin on the myocardium are mediated by oxygen free radicals

21 January 2018

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Melatonin protects against cardiac toxicity of doxorubicin in rat.

21 January 2018

1 reference

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Preventive effect of melatonin against cyanide-induced seizures and lipid peroxidation in mice.

21 January 2018

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Melatonin attenuates L-cysteine-induced seizures and lipid peroxidation in the brain of mice.

21 January 2018

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Effect of melatonin, piperonyl butoxide, or cobalt chloride on L-cysteine-induced lipid peroxidation in homogenate from whole brain of mice.

21 January 2018

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Biochemistry of Oxidative Stress

21 January 2018

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