OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes (Q28201794)

7

Michel Nussenzweig

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Anna Gazumyan

4

Anna Gazumyan

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Mila Jankovic

2

Mila Jankovic

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Rafael Casellas

1

Rafael Casellas

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author name string

Gesa Meyer

3

0 references

Yan Luo

5

0 references

Robert Roeder

Conserved sequence elements in K promoters from mice and humans: implications for transcriptional regulation and repertoire expression

6

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language of work or name

English

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publication date

6 September 2002

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published in

Cell

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volume

110

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issue

5

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page(s)

575-85

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cites work

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Recombination between immunoglobulin variable region gene segments is enhanced by transcription

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Contribution of Receptor Editing to the Antibody Repertoire

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Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface

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Editing disease-associated autoantibodies

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Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate

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Receptor editing: an approach by autoreactive B cells to escape tolerance

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The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes

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Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA

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A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors

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Immune receptor editing: revise and select

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Efficient transcription of an immunoglobulin kappa promoter requires specific sequence elements overlapping with and downstream of the transcriptional start site

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Activation of octamer-containing promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of immunoglobulin promoters.

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Light chain replacement: a new model for antibody gene rearrangement

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OCA-B integrates B cell antigen receptor-, CD40L- and IL 4-mediated signals for the germinal center pathway of B cell development

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Receptor editing occurs frequently during normal B cell development.

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Coactivator OBF-1 makes selective contacts with both the POU-specific domain and the POU homeodomain and acts as a molecular clamp on DNA.

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B-cell-specif ic coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation

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Deletion of germline promoter PD beta 1 from the TCR beta locus causes hypermethylation that impairs D beta 1 recombination by multiple mechanisms.

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An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

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Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement

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Identifiers

DOI

0 references

Fatcat ID

release_eubxqpplgnabrctbqo4kwopnda

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/eubxqpplgnabrctbqo4kwopnda

24 November 2022