Identification of a novel Ras-regulated proapoptotic pathway (Q28203664)

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Shahrooz Rabizadeh

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Maria Nedwidek

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Tao Chen

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Xian-feng Zhang

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Brian Seed

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Joseph Avruch

Understanding Ras: 'it ain't over 'til it's over'.

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language of work or name

English

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publication date

19 February 2002

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published in

Current Biology

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volume

12

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issue

4

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page(s)

253-65

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cites work

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The effector interactions of p21ras

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Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells

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Multiple Ras functions can contribute to mammalian cell transformation

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Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

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Cell cycle-dependent activation of Ras.

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Ras caught in another affair: the exchange factors for Ral.

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Identification of AF-6 and canoe as putative targets for Ras.

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A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1

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Identification of Nore1 as a potential Ras effector

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Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

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Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene

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Ras-induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation

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Ras versus cyclin-dependent kinase inhibitors

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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Integration of positive and negative growth signals during ras pathway activation in vivo

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p19ARF links the tumour suppressor p53 to Ras

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p14ARF links the tumour suppressors RB and p53.

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Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability

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Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

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Suppression of Ras-induced apoptosis by the Rac GTPase

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Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species

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Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression

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The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis

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Cloning and characterization of a human protein kinase with homology to Ste20

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Newly identified stress-responsive protein kinases, Krs-1 and Krs-2

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The Ste20 group kinases as regulators of MAP kinase cascades

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Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

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Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis.

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Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.

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Analysis of function and regulation of proteins that mediate signal transduction by use of lipid-modified plasma membrane-targeting sequences

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The importance of being K-Ras

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Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

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Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation.

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Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

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Ras signaling in tumor necrosis factor-induced apoptosis.

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Ras activation leads to cell proliferation or apoptotic cell death upon interleukin-2 stimulation or lymphokine deprivation, respectively

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Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis

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A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

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A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture

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Isolation, characterization and localization of annexin V from chicken liver

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Flow cytometry of apoptotic cell death

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Neurotrophin dependence mediated by p75NTR: contrast between rescue by BDNF and NGF.

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An alternative, nonapoptotic form of programmed cell death

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