Nerve growth factor activates persistent Rap1 signaling in endosomes (Q28207982)

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C F Lai

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W C Mobley

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Chengbiao Wu

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Chun-Fai Lai

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William C. Mobley

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

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language of work or name

English

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publication date

1 August 2001

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published in

Journal of Neuroscience

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volume

21

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issue

15

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page(s)

5406-16

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5406-5416

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cites work

1 reference

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Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

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NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway

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Signalling organelle for retrograde axonal transport of internalized neurotrophins from the nerve terminal.

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Neurotrophin receptors: mediators of life and death

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The caveolae membrane system

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Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

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The receptor recycling pathway contains two distinct populations of early endosomes with different sorting functions

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Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.

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ADP ribosylation factor 1 is required for synaptic vesicle budding in PC12 cells.

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The nerve growth factor family of receptors

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Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

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A signaling endosome hypothesis to explain NGF actions: potential implications for neurodegeneration

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EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif

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Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells

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Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

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Extracellular-signal-regulated kinase signalling in neurons

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Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons

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In AtT20 and HeLa cells brefeldin A induces the fusion of tubular endosomes and changes their distribution and some of their endocytic properties

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Tissue and subcellular distributions of the smg-21/rap1/Krev-1 proteins which are partly distinct from those of c-ras p21s

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Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

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Differentiation of PC12 cells in response to a cAMP analogue is accompanied by sustained activation of mitogen-activated protein kinase. Comparison with the effects of insulin, growth factors and phorbol esters

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An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons

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Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1

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Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G

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PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

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NGF-stimulated retrograde transport of trkA in the mammalian nervous system

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The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

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Gab1 mediates neurite outgrowth, DNA synthesis, and survival in PC12 cells

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NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation

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Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

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Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1

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ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

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All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral.

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Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes

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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

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Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex

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Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses

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Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504.

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Insulin and epidermal growth factor stimulate a conformational change in Rap1 and dissociation of the CrkII-C3G complex

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The morphology but not the function of endosomes and lysosomes is altered by brefeldin A

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Nerve growth factor signaling in caveolae-like domains at the plasma membrane

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Tyrosine kinase receptors concentrated in caveolae-like domains from neuronal plasma membrane

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A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA.

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12 December 2020

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

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Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

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12 December 2020