Insulin and epidermal growth factor stimulate a conformational change in Rap1 and dissociation of the CrkII-C3G complex (Q42446298)

31 October 2017

Insulin and epidermal growth factor stimulate a conformational change in Rap1 and dissociation of the CrkII-C3G complex (English)

1 reference

31 October 2017

Okada S

1

1 reference

PubMed ID

9353263

31 October 2017

Pessin JE

series ordinal

2

1 reference

PubMed ID

9353263

31 October 2017

language of work or name

English

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publication date

1 November 1997

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Journal of Biological Chemistry

31 October 2017

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31 October 2017

272

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31 October 2017

28179-28182

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31 October 2017

45

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The GTPase superfamily: a conserved switch for diverse cell functions

31 October 2017

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

The GTPase superfamily: conserved structure and molecular mechanism

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Complex formation between RAS and RAF and other protein kinases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Activation of the MAP kinase pathway by the protein kinase raf

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Raf-1 activates MAP kinase-kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Raf meets Ras: completing the framework of a signal transduction pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Signal transduction via the MAP kinases: proceed at your own RSK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Transcriptional regulation by extracellular signals: mechanisms and specificity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and Krev-1.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Insulin-stimulated disassociation of the SOS-Grb2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

Epidermal Growth Factor Receptor Targeting Prevents Uncoupling of the Grb2-SOS Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.45.28179

21 January 2018

Identifiers

DOI

10.1074/JBC.272.45.28179

1 reference

31 October 2017

1 reference

PubMed ID

9353263