Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR (Q28208397)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11278865%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

title

Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR (English)

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6 November 2019

4

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6 November 2019

author name string

Wong AH

1

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6 November 2019

Durbin JE

2

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6 November 2019

Li S

3

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6 November 2019

Decker T

5

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6 November 2019

Koromilas AE

6

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6 November 2019

language of work or name

English

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publication date

25 January 2001

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Journal of Biological Chemistry

6 November 2019

published in

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6 November 2019

volume

276

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6 November 2019

page(s)

13727-13737

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6 November 2019

issue

17

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Jaks and STATs: biological implications

6 November 2019

cites work

1 reference

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How cells respond to interferons

21 January 2018

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STATs and gene regulation

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Serine phosphorylation of STATs

21 January 2018

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Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways

21 January 2018

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Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

21 January 2018

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Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

21 January 2018

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The double-stranded RNA-dependent protein kinase PKR: structure and function

21 January 2018

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Translational control in mammalian cells

21 January 2018

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Regulation of the interferon-induced PKR: can viruses cope?

21 January 2018

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Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase

21 January 2018

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Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection

21 January 2018

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The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus.

21 January 2018

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Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

21 January 2018

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Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

21 January 2018

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Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase

21 January 2018

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Upregulation of STAT1 protein in cells lacking or expressing mutants of the double-stranded RNA-dependent protein kinase PKR.

21 January 2018

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Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

21 January 2018

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Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53

21 January 2018

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The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

21 January 2018

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Examination of the potential functional role of conserved cysteine residues in the hormone binding domain of the human 1,25-dihydroxyvitamin D3 receptor.

21 January 2018

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Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation

21 January 2018

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A factor induced by differentiation signals in cells of the macrophage lineage binds to the gamma interferon activation site

21 January 2018

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Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.

21 January 2018

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Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling

21 January 2018

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Interaction of the human protein kinase PKR with the mouse PKR homolog occurs via the N-terminal region of PKR and does not inactivate autophosphorylation activity of mouse PKR.

21 January 2018

1 reference

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Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

21 January 2018

1 reference

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High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons

21 January 2018

1 reference

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Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR)

21 January 2018

1 reference

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Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae

21 January 2018

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Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

21 January 2018

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Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation

21 January 2018

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Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation

21 January 2018

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Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways.

21 January 2018

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Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.

21 January 2018

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Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases

21 January 2018

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A new player in cell death

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M011240200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11278865%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference