The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro (Q28144828)

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scientific article (publication date: 29 April 1999)

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English	The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro	scientific article (publication date: 29 April 1999)

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scholarly article

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The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro (English)

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phosphorylation

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author name string

A R Cuddihy

1

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A H Wong

2

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N W Tam

3

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S Li

4

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A E Koromilas

5

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language of work or name

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publication date

29 April 1999

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18

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17

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2690-702

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Recruitment of p300/CBP in p53-dependent signal pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Mapping of the p53 and mdm-2 interaction domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Binding of an interferon-inducible protein (p202) to the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

The double-stranded RNA-dependent protein kinase PKR: structure and function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Cytoplasmic p53 polypeptide is associated with ribosomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

p53 is covalently linked to 5.8S rRNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Participation of the human p53 3'UTR in translational repression and activation following gamma-irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Two functionally distinct RNA-binding motifs in the regulatory domain of the protein kinase DAI

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Synergistic activation of transcription by CBP and p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Regulation of the specific DNA binding function of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Regulation of the interferon-induced PKR: can viruses cope?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Binding and modulation of p53 by p300/CBP coactivators

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

pEF-BOS, a powerful mammalian expression vector

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Interaction of the human protein kinase PKR with the mouse PKR homolog occurs via the N-terminal region of PKR and does not inactivate autophosphorylation activity of mouse PKR.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

How phosphorylation regulates the activity of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

p53 domains: identification and characterization of two autonomous DNA-binding regions.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Life, death, and the pursuit of apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

21 January 2018

Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of E2F-mediated transcription by p202

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 and translational control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

7 January 2021

based on heuristic

inferred from DOI database lookup

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

7 January 2021

based on heuristic

inferred from DOI database lookup

Translational regulation of human p53 gene expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

7 January 2021

based on heuristic

inferred from DOI database lookup

Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

7 January 2021

based on heuristic

inferred from DOI database lookup

Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

7 January 2021

based on heuristic

inferred from DOI database lookup

The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

7 January 2021

based on heuristic

inferred from DOI database lookup

The apoptosis pathway triggered by the interferon-induced protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2, and involves ICE-like proteases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

7 January 2021

based on heuristic

inferred from DOI database lookup

Negative feedback regulation of wild-type p53 biosynthesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

7 January 2021

based on heuristic

inferred from DOI database lookup

p53-catalyzed annealing of complementary single-stranded nucleic acids

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutagenesis in the P53 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

7 January 2021

based on heuristic

inferred from DOI database lookup

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202620

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1202620

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Springer Nature article ID

10.1038/sj.onc.1202620

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