Therapeutic effects of nitric oxide-aspirin hybrid drugs (Q28210282)

Expert Opinion on Therapeutic Targets

Europe PubMed Central

title

Therapeutic effects of nitric oxide-aspirin hybrid drugs (English)

0 references

1 reference

Ian L Megson

3

0 references

author name string

Catriona M Turnbull

series ordinal

1

0 references

Adriano G Rossi

series ordinal

2

0 references

language of work or name

English

0 references

publication date

December 2006

0 references

published in

0 references

volume

10

0 references

issue

6

0 references

page(s)

911-22

0 references

cites work

Nonsteroidal antiinflammatory drugs and the risk of myocardial infarction in the general population

1 reference

https://api.crossref.org/works/10.1517/14728222.10.6.911

Atherosclerosis — An Inflammatory Disease

20 April 2017

1 reference

https://api.crossref.org/works/10.1517/14728222.10.6.911

Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study

20 April 2017

1 reference

https://api.crossref.org/works/10.1517/14728222.10.6.911

NCX4016 (NO-aspirin) reduces infarct size and suppresses arrhythmias following myocardial ischaemia/reperfusion in pigs

20 April 2017

1 reference

https://api.crossref.org/works/10.1517/14728222.10.6.911

Prostate cancer and use of nonsteroidal anti-inflammatory drugs: systematic review and meta-analysis

20 April 2017

1 reference

https://api.crossref.org/works/10.1517/14728222.10.6.911

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide

20 April 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Nitrergic transmission: nitric oxide as a mediator of non-adrenergic, non-cholinergic neuro-effector transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Acetylation of prostaglandin synthase by aspirin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Pharmacology and potential therapeutic applications of nitric oxide-releasing non-steroidal anti-inflammatory and related nitric oxide-donating drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Upper gastrointestinal disease in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Focal gastric mucosal blood flow at the site of aspirin-induced ulceration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

NO-aspirins: a class of new anti-inflammatory and antithrombotic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Nitric oxide in mucosal defense: a little goes a long way.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Anti-thrombotic effects of a nitric oxide-releasing, gastric-sparing aspirin derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

A common pathway for nitric oxide release from NO-aspirin and glyceryl trinitrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Anti-inflammatory effects of aspirin and sodium salicylate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

The role of aspirin-triggered lipoxins in the mechanism of action of aspirin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

The possible role of the NO-cGMP pathway in nociception: different spinal and supraspinal action of enzyme blockers on rat dorsal horn neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

A comparison of the anti-inflammatory and anti-nociceptive activity of nitroaspirin and aspirin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

NCX4016 (NO-Aspirin) has multiple inhibitory effects in LPS-stimulated human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

TNF-alpha as a promising therapeutic target in chronic asthma: a lesson from rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Joint inflammation and cytokine inhibition in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Systemic nature of endothelial dysfunction in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Mechanisms of dysfunction of the nitric oxide pathway in vascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Endothelial nitric oxide synthase, caveolae and the development of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Nitroprusside in vitro inhibits platelet aggregation and intracellular calcium translocation. Effect of haemoglobin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Inositol 1,4,5-triphosphate-induced granule secretion in platelets. Evidence that the activation of phospholipase C mediated by platelet thromboxane receptors involves a guanine nucleotide binding protein-dependent mechanism distinct from that of th

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

The antithrombotic profile of aspirin. Aspirin resistance, or simply failure?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

A potential role for extracellular nitric oxide generation in cGMP-independent inhibition of human platelet aggregation: biochemical and pharmacological considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Evidence for a cyclic GMP-independent mechanism in the anti-platelet action of S-nitrosoglutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Potential cardioprotective actions of no-releasing aspirin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Antiaggregating and vasodilatory effects of a new nitroderivative of acetylsalicylic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Regulation of endothelial nitric-oxide synthase during hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryl trinitrate-tolerant rat femoral arteries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Rapid, agonist-dependent phosphorylation in vivo of human thromboxane receptor isoforms. Minimal involvement of protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Low-dose aspirin for the prevention of atherothrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Inhibition of platelet prostaglandin synthetase by oral aspirin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Coxibs and cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Thromboxane, prostaglandin and leukotriene receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Stimulation of Endothelial Cell Prostacyclin Production by Thrombin, Trypsin, and the Ionophore A 23187

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Celecoxib and cardiovascular risks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Aspirin as an antiplatelet drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Platelet-active drugs : the relationships among dose, effectiveness, and side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

NCX 4016, a nitric oxide-releasing aspirin, modulates adrenergic vasoconstriction in the perfused rat tail artery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Nitrosylhemoglobin, an unequivocal index of nitric oxide release from nitroaspirin: in vitro and in vivo studies in the rat by ESR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Nitric oxide-donating non-steroidal anti-inflammatory drugs: the case of nitroderivatives of aspirin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Cyclooxygenase, NSAIDs, and colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Prostaglandins and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Prostaglandins, their inhibitors and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Molecular targets of nitric-oxide-donating aspirin in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Positional isomerism markedly affects the growth inhibition of colon cancer cells by nitric oxide-donating aspirin in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Nitric oxide donating nonsteroidal anti-inflammatory drugs induce apoptosis in human prostate cancer cell systems and human prostatic stroma via caspase-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Cyclooxygenase-independent chemoprevention with an aspirin derivative in a rat model of colonic adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Atherosclerotic plaque rupture in the apolipoprotein E knockout mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Nitric oxide-induced genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells expressing wild-type and mutant p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Explaining the phenomenon of nitrate tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Sildenafil prevents indomethacin-induced gastropathy in rats: role of leukocyte adherence and gastric blood flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Sildenafil offers protection against NSAID-induced gastric injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911

Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.6.911