Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes (Q28213013)

1

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Derek J Parks

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Linda B Moore

3

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Jon L Collins

4

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Bryan Goodwin

5

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Catherine A Stoltz

7

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Steven A Kliewer

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Millard H Lambert

9

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Timothy M Willson

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John T Moore

Journal of Biological Chemistry

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language of work or name

English

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publication date

9 May 2003

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published in

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volume

278

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issue

19

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page(s)

17277-83

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cites work

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An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

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The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

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Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

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Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

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Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

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Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

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Use of the nuclear receptor PXR to predict drug interactions

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

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St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

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The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

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The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

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Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

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Bile acids: natural ligands for an orphan nuclear receptor

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Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

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The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand

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Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.

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Cyclosporine and liver transplantation: will the midazolam test make blood level monitoring obsolete?

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Molecular basis of ethnic differences in drug disposition and response

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A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption

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The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

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Identifiers

DOI

10.1074/JBC.M300138200

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12611900

1 reference

Consolidated OpenCitations Corpus – April 2017