Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man. (Q34604457)

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English	Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man. (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

author name string

Gibson GG

1

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Europe PubMed Central

PubMed publication ID

3 August 2017

Plant NJ

2

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Europe PubMed Central

PubMed publication ID

3 August 2017

Swales KE

3

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Europe PubMed Central

PubMed publication ID

3 August 2017

Ayrton A

4

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Europe PubMed Central

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3 August 2017

El-Sankary W

5

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Europe PubMed Central

PubMed publication ID

3 August 2017

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publication date

1 March 2002

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

PubMed publication ID

3 August 2017

32

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Europe PubMed Central

PubMed publication ID

3 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

165-206

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Europe PubMed Central

PubMed publication ID

3 August 2017

Intersubject and dose-related variability after intravenous administration of erythromycin.

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A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

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21 January 2018

Gene regulation by steroid hormones

1 reference

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21 January 2018

Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7.

1 reference

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21 January 2018

Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes

1 reference

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21 January 2018

Characterization of the human cytochrome P4502D6 promoter. A potential role for antagonistic interactions between members of the nuclear receptor family

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21 January 2018

Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

1 reference

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21 January 2018

The role of individual human cytochromes P450 in drug metabolism and clinical response

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21 January 2018

The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons

1 reference

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21 January 2018

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

1 reference

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21 January 2018

Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells

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21 January 2018

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

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21 January 2018

CYP3A5 is the major cytochrome P450 3A expressed in human colon and colonic cell lines.

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21 January 2018

Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation

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21 January 2018

Cell-type specific activity of two glucocorticoid responsive units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor

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21 January 2018

The fetal specific gene CYP3A7 is inducible by rifampicin in adult human hepatocytes in primary culture.

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21 January 2018

Cytochrome P-450 3A4: regulation and role in drug metabolism

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21 January 2018

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

1 reference

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21 January 2018

Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.

1 reference

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21 January 2018

Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.

1 reference

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21 January 2018

A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR).

1 reference

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21 January 2018

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

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21 January 2018

Effect of age and gender on the activity of human hepatic CYP3A

1 reference

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21 January 2018

Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression

1 reference

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21 January 2018

Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif

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21 January 2018

Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene

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21 January 2018

Novel glucocorticoid receptor coactivator effector mechanisms

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21 January 2018

Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7

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21 January 2018

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

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21 January 2018

Purification and properties of cytochrome P-450 from homogenates of human fetal livers

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21 January 2018

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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CYP3A gene expression in human gut epithelium

1 reference

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21 January 2018

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

1 reference

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21 January 2018

A major glucocorticoid-inducible P450 in rat liver is not P450 3A1.

1 reference

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21 January 2018

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

1 reference

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21 January 2018

The induction of five rat hepatic P450 cytochromes by phenobarbital and similarly acting compounds is regulated by a sexually dimorphic, dietary-dependent endocrine factor that is highly strain specific

1 reference

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21 January 2018

Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics

1 reference

https://api.crossref.org/works/10.1080%2F00498250110102674

21 January 2018

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

1 reference

https://api.crossref.org/works/10.1080%2F00498250110102674

21 January 2018

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

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21 January 2018

Substrates of human hepatic cytochrome P450 3A4.

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21 January 2018

Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA.

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21 January 2018

The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse

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21 January 2018

Molecular mechanisms of genetic polymorphisms of drug metabolism

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21 January 2018

A gene structure of testosterone 6 beta-hydroxylase (P450IIIA).

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Transcriptional elements directing a liver-specific expression of P450/6 beta A (CYP3A2) gene-encoding testosterone 6 beta-hydroxylase

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

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The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications

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Induction of drug metabolism by nuclear receptor CAR: molecular mechanisms and implications for drug research

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A unified nomenclature system for the nuclear receptor superfamily

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A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro

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Hepatocyte nuclear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AI regulatory protein I and v-ErbA-related protein 3.

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Differential catalytic properties in metabolism of endogenous and exogenous substrates among CYP3A enzymes expressed in COS-7 cells

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The steroid receptor antagonists RU40555 and RU486 activate glucocorticoid receptor translocation and are not excreted by the steroid hormones transporter in L929 cells

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Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene

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21 January 2018

Control and statistical analysis of in vitro reporter gene assays.

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A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids

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Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.

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Frequency of cytochrome P450 3A4 variant genotype in transplant population and lack of association with cyclosporin clearance

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A novel female-specific member of the CYP3A gene subfamily in the mouse liver

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CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity

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21 January 2018

P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans

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Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

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Isolation of CYP3A5P cDNA from human liver: a reflection of a novel cytochrome P-450 pseudogene

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Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

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Induction and drug development

1 reference

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21 January 2018

Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450.

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Characterization of orphan nuclear receptor binding elements in sex-differentiated members of the CYP2C gene family expressed in rat liver

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The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

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Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

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Effect of dexamethasone and phenobarbital on run-on transcription rate and CYP3A mRNA concentration in rat liver: changes during development

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Pharmacokinetic drug interactions with rifampicin

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SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.

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Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

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21 January 2018

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

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21 January 2018

Assessment of drug-drug interactions: concepts and approaches

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21 January 2018

Cytochrome P4503A (CYP3A) metabolism: prediction of in vivo activity in humans

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Implications and consequences of enzyme induction on preclinical and clinical drug development

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21 January 2018

The human CYP3A subfamily: practical considerations

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21 January 2018

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

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21 January 2018

The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver

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21 January 2018

Noninvasive tests of CYP3A enzymes

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21 January 2018

Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans

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21 January 2018

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

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21 January 2018

Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method

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21 January 2018

Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

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21 January 2018

Population distribution and effects on drug metabolism of a genetic variant in the 5' promoter region of CYP3A4

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21 January 2018

Rifampicin treatment greatly increases the apparent oral clearance of quinidine

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21 January 2018

Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization

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21 January 2018

Inductive and repressive effects of rifampicin on rabbit liver microsomal cytochrome P-450

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Effects of steroids on progesterone output by explants of human chorion

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Human cytochrome P450s: selectivity and measurement in vivo

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Molecular modeling of cytochrome P450 3A4

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21 January 2018

Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4

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21 January 2018

Induction of the cytochrome P450 3A subfamily in rat liver correlates with the binding of inducers to a microsomal protein

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21 January 2018

Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation

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21 January 2018

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10.1080/00498250110102674

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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24 November 2022

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Europe PubMed Central

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3 August 2017

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