CD28 function: a balance of costimulatory and regulatory signals (Q28215020)

12 December 2020

Absence of B7-dependent responses in CD28-deficient mice

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12 December 2020

CD28 costimulation promotes the production of Th2 cytokines

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12 December 2020

Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism.

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12 December 2020

CTLA-4 regulates induction of anergy in vivo

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12 December 2020

Functional responses and costimulator dependence of memory CD4+ T cells.

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12 December 2020

ICOS co-stimulatory receptor is essential for T-cell activation and function

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12 December 2020

Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease

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12 December 2020

Treatment of murine lupus with CTLA4Ig

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12 December 2020

Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells

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12 December 2020

The roles of CD28 and CD40 ligand in T cell activation and tolerance

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12 December 2020

CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes

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12 December 2020

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases.

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12 December 2020

Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses

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12 December 2020

Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

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12 December 2020

High concentrations of antigenic ligand activate and do not tolerize naive CD4 T cells in the absence of CD28/B7 costimulation

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12 December 2020

Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous

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12 December 2020

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

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12 December 2020

Distinct roles for B7 costimulation in contact hypersensitivity and humoral immune responses to epicutaneous antigen

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12 December 2020

CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production

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12 December 2020

Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis

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12 December 2020

ICOS is essential for effective T-helper-cell responses

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12 December 2020

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse

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12 December 2020

CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy

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12 December 2020

ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement

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12 December 2020

ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses

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12 December 2020

The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival

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12 December 2020

B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.

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12 December 2020

CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis

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12 December 2020

B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

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12 December 2020

The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE.

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12 December 2020

Either B7 costimulation or IL-2 can elicit generation of primary alloreactive CTL

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12 December 2020

Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood

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12 December 2020

Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice.

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12 December 2020

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

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12 December 2020

Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation

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12 December 2020

CD4 help-independent induction of cytotoxic CD8 cells to allogeneic P815 tumor cells is absolutely dependent on costimulation

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12 December 2020

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

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12 December 2020

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

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12 December 2020

Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells

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12 December 2020

CD28/B7 system of T cell costimulation

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12 December 2020

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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12 December 2020

Regulatory T cells in the control of immune pathology.

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12 December 2020

Regulatory T cells: key controllers of immunologic self-tolerance

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12 December 2020

Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE

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12 December 2020

The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function

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12 December 2020

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

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12 December 2020

LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production

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12 December 2020

CD28-independent costimulation of T cells in alloimmune responses.

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12 December 2020

Differential T cell costimulatory requirements in CD28-deficient mice

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12 December 2020

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions

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12 December 2020

Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo.

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12 December 2020

Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis.

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12 December 2020

Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation

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12 December 2020

Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production

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12 December 2020

Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

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12 December 2020

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

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12 December 2020

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

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12 December 2020

B7.2 has opposing roles during the activation versus effector stages of experimental autoimmune thyroiditis

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12 December 2020

In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance.

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12 December 2020

Functional diversity of helper T lymphocytes

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12 December 2020

Intercellular adhesion molecule 1 is critical for activation of CD28-deficient T cells

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12 December 2020

Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection

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12 December 2020

B7 interactions with CD28 and CTLA-4 control tolerance or induction of mucosal inflammation in chronic experimental colitis

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12 December 2020

Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells

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12 December 2020

Interleukin-12 can replace CD28-dependent T-cell costimulation during nonspecific cytotoxic T lymphocyte induction by anti-CD3 antibody

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12 December 2020

Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells

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12 December 2020

Duration of TCR stimulation determines costimulatory requirement of T cells

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12 December 2020