A critical review of the fluoroquinolones: focus on respiratory infections (Q28215446)

Europe PubMed Central

title

A critical review of the fluoroquinolones: focus on respiratory infections (English)

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1

George G Zhanel

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author name string

Kelly Ennis

2

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Lavern Vercaigne

3

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Andrew Walkty

4

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Alfred S Gin

5

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John Embil

6

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Heather Smith

7

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Daryl J Hoban

https://scigraph.springernature.com/pub.10.2165/00003495-200262010-00002

8

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language of work or name

English

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publication date

2002

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published in

Drugs

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volume

62

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issue

1

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page(s)

13-59

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exact match

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cites work

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Comparative in vitro activity of BAY 12-8039 and five other antimicrobial agents against anaerobic bacteria

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Timed kill kinetic studies of levofloxacin, ofloxacin, and ciprofloxacin against Moraxella catarrhalis

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Comparative in vitro activities of DU-6859a, levofloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against 387 aerobic and anaerobic bite wound isolates

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12 December 2020

In-vitro activity of levofloxacin against Streptococcus pneumoniae with various levels of penicillin resistance

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12 December 2020

Penetration of sparfloxacin and ciprofloxacin into alveolar macrophages, epithelial lining fluid, and polymorphonuclear leucocytes.

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12 December 2020

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Steady-state plasma and intrapulmonary concentrations of levofloxacin and ciprofloxacin in healthy adult subjects

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In-vitro activity of trovafloxacin against clinical bacterial isolates from patients with cancer.

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12 December 2020

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12 December 2020

Trovafloxacin concentrations in airway fluids of patients with severe community-acquired pneumonia

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12 December 2020

Safety profile of grepafloxacin compared with other fluoroquinolones

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12 December 2020

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12 December 2020

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Pharmacokinetics of a once-daily oral dose of moxifloxacin (Bay 12-8039), a new enantiomerically pure 8-methoxy quinolone

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12 December 2020

Activities of three quinolones, alone and in combination with extended-spectrum cephalosporins or gentamicin, against Stenotrophomonas maltophilia

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12 December 2020

In-vitro activity of grepafloxacin, a new fluoroquinolone, against mycoplasmas

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12 December 2020

Sparfloxacin. A review of its antibacterial activity, pharmacokinetic properties, clinical efficacy and tolerability in lower respiratory tract infections

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12 December 2020

Comparative antimicrobial activity of trovafloxacin tested against 3049 Streptococcus pneumoniae isolates from the 1997-1998 respiratory infection season

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12 December 2020

Activities of telithromycin (HMR 3647, RU 66647) compared to those of erythromycin, azithromycin, clarithromycin, roxithromycin, and other antimicrobial agents against unusual anaerobes

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12 December 2020

Pharmacodynamics of fluoroquinolones.

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12 December 2020

In vitro activity of levofloxacin against gram-positive bacteria

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12 December 2020

Activity of gemifloxacin against penicillin- and ciprofloxacin-resistant Streptococcus pneumoniae displaying topoisomerase- and efflux-mediated resistance mechanisms

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12 December 2020

Concentrations of trovafloxacin in bronchial mucosa, epithelial lining fluid, alveolar macrophages and serum after administration of single or multiple oral doses to patients undergoing fibre-optic bronchoscopy

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12 December 2020

Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.

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12 December 2020

In vitro activity of gemifloxacin compared with other antimicrobial agents against recent clinical isolates of streptococci

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12 December 2020

The in-vitro activity and tentative breakpoint of gemifloxacin, a new fluoroquinolone

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12 December 2020

Comparative activity of trovafloxacin and Bay 12-8039 against 452 clinical isolates of Streptococcus pneumoniae

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12 December 2020

Comparative activity of moxifloxacin in vitro against obligately anaerobic bacteria

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12 December 2020

Pharmacokinetics and pharmacodynamics of the new fluoroquinolones: focus on respiratory infections

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12 December 2020

Prevalence of gyrA, gyrB, parC, and parE mutations in clinical isolates of Streptococcus pneumoniae with decreased susceptibilities to different fluoroquinolones and originating from Worldwide Surveillance Studies during the 1997-1998 respiratory se

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12 December 2020

In vitro activity of the new quinolone moxifloxacin (Bay 12-8039) against resistant gram-positive clinical isolates.

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12 December 2020

ParC and GyrA may be interchangeable initial targets of some fluoroquinolones in Streptococcus pneumoniae

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12 December 2020

Susceptibility of penicillin-susceptible and -resistant pneumococci to CFC-222, a new fluoroquinolone

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12 December 2020

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12 December 2020

In vitro activity of HSR-903, a new quinolone

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Pharmacokinetics and penetration into inflammatory fluid of trovafloxacin (CP-99,219).

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12 December 2020

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12 December 2020

Susceptibility of Moraxella catarrhalis to 21 antimicrobial drugs: validity of current NCCLS criteria for the interpretation of agar disk diffusion antibiograms

1 reference

12 December 2020

Safety of trovafloxacin in treatment of lower respiratory tract infections

1 reference

12 December 2020

Antibacterial activity of AM-1155 against penicillin-resistant Streptococcus pneumoniae

1 reference

12 December 2020

Antipneumococcal activity of MEN 10700, a new penem, compared with other compounds, by MIC and time-kill kinetics

1 reference

12 December 2020

In-vitro activity of levofloxacin, a new fluoroquinolone: evaluation against Haemophilus influenzae and Moraxella catarrhalis.

1 reference

12 December 2020

In vitro activity of BAY 12-8039, a new 8-methoxyquinolone.

1 reference

12 December 2020

In vitro activity of trovafloxacin against ciprofloxacin-susceptible and -resistant clinical bacterial isolates and assessment of the trovafloxacin disk test.

1 reference

12 December 2020

New topoisomerase essential for chromosome segregation in E. coli.

1 reference

12 December 2020

Concentrations of moxifloxacin in serum and pulmonary compartments following a single 400 mg oral dose in patients undergoing fibre-optic bronchoscopy

1 reference

12 December 2020

Clinical effectiveness of levofloxacin in patients with acute purulent exacerbations of chronic bronchitis: the relationship with in-vitro activity.

1 reference

12 December 2020

Quinolone accumulation by Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli

1 reference

12 December 2020

In vitro development of resistance to five quinolones and amoxicillin-clavulanate in Streptococcus pneumoniae.

1 reference

12 December 2020

Levofloxacin in the treatment of community acquired pneumonia

1 reference

12 December 2020

Comparative in-vitro activity of levofloxacin, other fluoroquinolones, doxycycline and erythromycin against Ureaplasma urealyticum and Mycoplasma hominis

1 reference

12 December 2020

In vitro activity of Bay 12-8039, a new 8-methoxyquinolone

1 reference

12 December 2020

Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae

1 reference

12 December 2020

Pharmacokinetics, safety, and tolerability of ascending single doses of moxifloxacin, a new 8-methoxy quinolone, administered to healthy subjects

1 reference

12 December 2020

Classification and structure-activity relationships of fluoroquinolones

1 reference

12 December 2020

Quinolone-induced QT interval prolongation: a not-so-unexpected class effect

1 reference

12 December 2020

The activity of grepafloxacin against respiratory pathogens in the UK.

1 reference

12 December 2020

Pharmacokinetic interactions related to the chemical structures of fluoroquinolones

1 reference

12 December 2020

Dual inhibitory activity of sitafloxacin (DU-6859a) against DNA gyrase and topoisomerase IV of Streptococcus pneumoniae

1 reference

12 December 2020

Comparative potency of gemifloxacin, new quinolones, macrolides, tetracycline and clindamycin against Mycoplasma spp

1 reference

12 December 2020

Comparison of in vitro activity of trovafloxacin against gram-positive and gram-negative organisms with quinolones and beta-lactam antimicrobial agents

1 reference

12 December 2020

The in-vitro activity of grepafloxacin against Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum and Legionella spp

1 reference

12 December 2020

The tolerance and pharmacokinetics of clinafloxacin (CI-960) in healthy subjects

1 reference

12 December 2020

In-vitro activities of ciprofloxacin, levofloxacin, lomefloxacin, ofloxacin, pefloxacin, sparfloxacin and trovafloxacin against gram-positive and gram-negative pathogens from respiratory tract infections

1 reference

12 December 2020

Mechanism of action of quinolones against Escherichia coli DNA gyrase

1 reference

12 December 2020

Contribution of topoisomerase IV and DNA gyrase mutations in Streptococcus pneumoniae to resistance to novel fluoroquinolones

1 reference

12 December 2020

Urinary excretion and bactericidal activity of intravenous ciprofloxacin compared with oral ciprofloxacin

1 reference

12 December 2020

Quinolone antimicrobial agents: mechanism of action and resistance development

1 reference

12 December 2020

In vitro activity of ciprofloxacin, levofloxacin, and trovafloxacin, alone and in combination with beta-lactams, against clinical isolates of Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Burkholderia cepacia

1 reference

12 December 2020

Lack of effect of gemifloxacin on the steady-state pharmacokinetics of theophylline in healthy volunteers

1 reference

12 December 2020

In-vitro bacteriostatic activity of levofloxacin and three other fluoroquinolones against penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae.

1 reference

12 December 2020

Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition

1 reference

12 December 2020

In vitro activity of R-95867, the active metabolite of a new oral carbapenem, CS-834, against anaerobic bacteria

1 reference

12 December 2020

Differential behaviors of Staphylococcus aureus and Escherichia coli type II DNA topoisomerases

1 reference

12 December 2020

Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae.

1 reference

12 December 2020

DNA cleavage activities of Staphylococcus aureus gyrase and topoisomerase IV stimulated by quinolones and 2-pyridones.

1 reference

12 December 2020

The susceptibility of Streptococcus pneumoniae to levofloxacin and other antibiotics.

1 reference

12 December 2020

Age and gender effects on the pharmacokinetics of gatifloxacin.

1 reference

12 December 2020

In vitro activities of clinafloxacin against contemporary clinical bacterial isolates from 10 North American centers

1 reference

12 December 2020

Trovafloxacin-induced acute hepatitis

1 reference

12 December 2020

Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-8 methoxyl group on survival in liquid media and in human macrophages

1 reference

12 December 2020

In vitro activity of moxifloxacin, a new 8-methoxyquinolone, against gram-positive bacteria.

1 reference

12 December 2020

Mechanism of inhibition of DNA gyrase by quinolone antibacterials: specificity and cooperativity of drug binding to DNA

1 reference

12 December 2020

Fluoroquinolone antimicrobial agents

1 reference

12 December 2020

Optimizing economic outcomes in antibiotic therapy of patients with acute bacterial exacerbations of chronic bronchitis

1 reference

12 December 2020

Potent antipneumococcal activity of gemifloxacin is associated with dual targeting of gyrase and topoisomerase IV, an in vivo target preference for gyrase, and enhanced stabilization of cleavable complexes in vitro

1 reference

12 December 2020

Fluoroquinolones: interaction profile during enteral absorption.

1 reference

12 December 2020

Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro

1 reference

12 December 2020

In vitro activities of 15 antimicrobial agents against clinical isolates of South African enterococci

1 reference

12 December 2020

Effect of food and gastric pH on the bioavailability of grepafloxacin.

1 reference

12 December 2020

Effects of food and sucralfate on a single oral dose of 500 milligrams of levofloxacin in healthy subjects

1 reference

12 December 2020

Effects of DU-6859a, a new quinolone antimicrobial, on theophylline metabolism in in vitro and in vivo studies

1 reference

12 December 2020

In vitro activities of antimicrobial agents, alone and in combinations, against Burkholderia cepacia isolated from blood

1 reference

12 December 2020

In vitro activity of levofloxacin against a selected group of anaerobic bacteria isolated from skin and soft tissue infections.

1 reference

12 December 2020

Antimicrobial activity and spectrum of LB20304, a novel fluoronaphthyridone

1 reference

12 December 2020

Clinical pharmacokinetics of sparfloxacin

1 reference

12 December 2020

Safety profile of sparfloxacin in the treatment of respiratory tract infections

1 reference

12 December 2020

Exploration of the in-vitro pharmacodynamic activity of moxifloxacin for Staphylococcus aureus and Streptococci of lancefield groups A and G.

1 reference

12 December 2020

In-vitro activity of HMR 3647 against Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and beta-haemolytic streptococci

1 reference

12 December 2020

Susceptibility of Legionella species to five antibiotics and development of resistance by exposure to erythromycin, ciprofloxacin, and rifampicin

1 reference

12 December 2020

Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. Canadian Bacterial Surveillance Network.

1 reference

12 December 2020

In vitro activity of OPC-17116 compared to other broad-spectrum fluoroquinolones

1 reference

12 December 2020

Comparison of the abilities of grepafloxacin and clarithromycin to eradicate potential bacterial pathogens from the sputa of patients with chronic bronchitis: influence of pharmacokinetic and pharmacodynamic variables.

1 reference

12 December 2020

Pharmacokinetics and safety of trovafloxacin in healthy male volunteers following administration of single intravenous doses of the prodrug, alatrofloxacin

1 reference

12 December 2020

Role of the new quinolones in pediatric practice.

1 reference

12 December 2020

Canadian guidelines for the initial management of community-acquired pneumonia: an evidence-based update by the Canadian Infectious Diseases Society and the Canadian Thoracic Society. The Canadian Community-Acquired Pneumonia Working Group

1 reference

12 December 2020

In vitro activity of gemifloxacin against a broad range of recent clinical isolates from the USA

1 reference

12 December 2020

Horizontal transfer of parC and gyrA in fluoroquinolone-resistant clinical isolates of Streptococcus pneumoniae

1 reference

12 December 2020

Trends in bacterial resistance to fluoroquinolones

1 reference

12 December 2020

Mutant prevention concentrations of fluoroquinolones for clinical isolates of Streptococcus pneumoniae.

1 reference

12 December 2020

Hepatobiliary elimination of trovafloxacin and metabolites following single oral doses in healthy volunteers.

1 reference

12 December 2020

Ciprofloxacin. An updated review of its pharmacology, therapeutic efficacy and tolerability

1 reference

12 December 2020

Italian survey on comparative levofloxacin susceptibility in 334 clinical isolates of Pseudomonas aeruginosa

1 reference

12 December 2020

In vitro activity of trovafloxacin (CP 99,219), a new fluoroquinolone against hospital isolates

1 reference

12 December 2020

Activity of moxifloxacin, administered once a day, against Streptococcus pneumoniae in an in vitro pharmacodynamic model of infection

1 reference

12 December 2020

Survey of susceptibilities of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis isolates to 26 antimicrobial agents: a prospective U.S. study

1 reference

12 December 2020

Primary targets of fluoroquinolones in Streptococcus pneumoniae.

1 reference

12 December 2020

Penetration of moxifloxacin into peripheral compartments in humans.

1 reference

12 December 2020

Survey of bloodstream infections due to gram-negative bacilli: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, and Latin America for the SENTRY Antimicrobial Surveillance Program, 1997

1 reference

12 December 2020

Comparative activity of trovafloxacin, alone and in combination with other agents, against gram-negative nonfermentative rods

1 reference

12 December 2020

Comparison of the postantibiotic and postantibiotic sub-MIC effects of levofloxacin and ciprofloxacin on Staphylococcus aureus and Streptococcus pneumoniae.

1 reference

12 December 2020

The cost of treating community-acquired pneumonia.

1 reference

12 December 2020

In vitro activities of sitafloxacin (DU-6859a) and six other fluoroquinolones against 8,796 clinical bacterial isolates

1 reference

12 December 2020

Activities of gatifloxacin compared to those of seven other agents against anaerobic organisms

1 reference

12 December 2020

Ciprofloxacin-warfarin coagulopathy: a case series

1 reference

12 December 2020

Multidrug resistance among Streptococcus pneumoniae isolated at a university hospital in eastern Tennessee

1 reference

12 December 2020

Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae

1 reference

12 December 2020

Antibacterial properties of AM-1155, a new 8-methoxy quinolone.

1 reference

12 December 2020

Lack of effect of gemifloxacin on the steady-state pharmacodynamics of warfarin in healthy volunteers

1 reference

12 December 2020

Mechanisms of resistance to fluoroquinolones: state-of-the-art 1992-1994.

1 reference

12 December 2020

Sparfloxacin pharmacokinetics in healthy volunteers: the influence of acidification and alkalinization.

1 reference

12 December 2020

1 reference

12 December 2020

Comparative activity of 27 antimicrobial compounds against 698 Streptococcus pneumoniae isolates originating from 20 European university hospitals. SENTRY Participants Group

1 reference

12 December 2020

A review of the comparative in-vitro activities of 12 antimicrobial agents, with a focus on five new respiratory quinolones'.

1 reference

12 December 2020

Activity of gatifloxacin compared to those of five other quinolones versus aerobic and anaerobic isolates from skin and soft tissue samples of human and animal bite wound infections.

1 reference

12 December 2020

Comparison of the fluoroquinolones based on pharmacokinetic and pharmacodynamic parameters

1 reference

12 December 2020

Growth and development in preterm infants receiving fluoroquinolones.

1 reference

12 December 2020

Inhibitory activities of quinolones against DNA gyrase and topoisomerase IV purified from Staphylococcus aureus

1 reference

12 December 2020

A multicenter, randomized study comparing the efficacy and safety of intravenous and/or oral levofloxacin versus ceftriaxone and/or cefuroxime axetil in treatment of adults with community-acquired pneumonia

1 reference

12 December 2020

Pharmacokinetics and inflammatory fluid penetration of clinafloxacin.

1 reference

12 December 2020

Emergence of fluoroquinolone resistance among multiply resistant strains of Streptococcus pneumoniae in Hong Kong

1 reference

12 December 2020

Randomized, double-blind study of short-course (5 day) grepafloxacin versus 10 day clarithromycin in patients with acute bacterial exacerbations of chronic bronchitis

1 reference

12 December 2020

In vitro antibacterial spectrum of a new broad-spectrum 8-methoxy fluoroquinolone, gatifloxacin

1 reference

12 December 2020

Comparison of in-vitro pharmacodynamics of once and twice daily ciprofloxacin

1 reference

12 December 2020

Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones.

1 reference

12 December 2020

Multiple-dose pharmacokinetics and safety of trovafloxacin in healthy volunteers

1 reference

12 December 2020

Antimicrobial activity of gatifloxacin compared to seven other compounds tested against gram-positive organisms isolated at 10 cancer-treatment centers

1 reference

12 December 2020

High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutations in parC and gyrA.

1 reference

12 December 2020

A convenient assay for estimating the possible involvement of efflux of fluoroquinolones by Streptococcus pneumoniae and Staphylococcus aureus: evidence for diminished moxifloxacin, sparfloxacin, and trovafloxacin efflux.

1 reference

12 December 2020

1 reference

12 December 2020

Activity and spectrum of 22 antimicrobial agents tested against urinary tract infection pathogens in hospitalized patients in Latin America: report from the second year of the SENTRY antimicrobial surveillance program (1998).

1 reference

12 December 2020

Levofloxacin. A review of its antibacterial activity, pharmacokinetics and therapeutic efficacy

1 reference

12 December 2020

Prevalence of antimicrobial resistance in respiratory tract isolates of Streptococcus pneumoniae: results of a Canadian national surveillance study. The Canadian Respiratory Infection Study Group

1 reference

12 December 2020

Treatment of acute exacerbations of chronic bronchitis: comparison of trovafloxacin and amoxicillin in a multicentre, double-blind, double-dummy study. Trovafloxacin Bronchitis Study Group

1 reference

12 December 2020

Comparative activity of clinafloxacin and nine other compounds tested against 2000 contemporary clinical isolates from patients in United States hospitals.

1 reference

12 December 2020

Pharmacokinetics of a fluoronaphthyridone, trovafloxacin (CP 99,219), in infants and children following administration of a single intravenous dose of alatrofloxacin

1 reference

12 December 2020

Extremely high incidence of macrolide and trimethoprim-sulfamethoxazole resistance among clinical isolates of Streptococcus pneumoniae in Taiwan

1 reference

12 December 2020

A study to determine the pharmacokinetics and inflammatory fluid penetration of gatifloxacin following a single oral dose

1 reference

12 December 2020

Pregnancy outcome following gestational exposure to fluoroquinolones: a multicenter prospective controlled study

1 reference

12 December 2020

Pharmacokinetics of grepafloxacin after oral administration of single and repeat doses in healthy young males

1 reference

12 December 2020

A comparative study of the in-vitro activity of levofloxacin against Streptococcus pneumoniae.

1 reference

12 December 2020

Pharmacokinetics and elimination of moxifloxacin after oral and intravenous administration in man

1 reference

12 December 2020

1 reference

12 December 2020