Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells (Q28216580)

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scientific article (publication date: 11 October 2002)

Language	Label	Description	Also known as
English	Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells	scientific article (publication date: 11 October 2002)

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scholarly article

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Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells (English)

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author name string

Jaejoon Won

1

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Jeongbin Yim

2

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Tae Kook Kim

3

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language of work or name

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publication date

11 October 2002

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Journal of Biological Chemistry

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277

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38230-8

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41

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Specific association of human telomerase activity with immortal cells and cancer

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Aging and cancer: are telomeres and telomerase the connection?

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Replicative senescence and cell immortality: the role of telomeres and telomerase

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Telomere biology in human aging and aging syndromes

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Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

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The RNA component of human telomerase

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A mammalian telomerase-associated protein

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Human telomerase contains evolutionarily conserved catalytic and structural subunits

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In vivo and in vitro analyses of Myc for differential promoter activities of the human telomerase (hTERT) gene in normal and tumor cells.

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Direct activation of TERT transcription by c-MYC.

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Telomerase activity in hybrids between telomerase-negative and telomerase-positive immortal human cells is repressed in the different complementation groups but not in the same complementation group of immortality

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Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells

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Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT.

1 reference

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Identification of Mad as a repressor of the human telomerase (hTERT) gene

1 reference

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Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells

1 reference

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Telomerase activation by histone deacetylase inhibitor in normal cells

1 reference

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Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells.

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Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

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Histone deacetylase 1 can repress transcription by binding to Sp1.

1 reference

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Sp3 and Sp4 can repress transcription by competing with Sp1 for the core cis-elements on the human ADH5/FDH minimal promoter

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Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function

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Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).

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Role of the LXCXE binding site in Rb function

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Insulin-like growth factor-I regulates transcription of the elastin gene through a putative retinoblastoma control element. A role for Sp3 acting as a repressor of elastin gene transcription.

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Sp3 represses transcription when tethered to promoter DNA or targeted to promoter proximal RNA.

1 reference

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Sp3 is a bifunctional transcription regulator with modular independent activation and repression domains.

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Platelet-derived growth factor-stimulated expression of the MCP-1 immediate-early gene involves an inhibitory multiprotein complex

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Identification of SP3 as a negative regulatory transcription factor in the monocyte expression of growth hormone

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Differential regulation of hepatitis B virus gene expression by the Sp1 transcription factor

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Sp1 activates and inhibits transcription from separate elements in the proximal promoter of the human adenine nucleotide translocase 2 (ANT2) gene.

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A role for Sp and helix-loop-helix transcription factors in the regulation of the human Id4 gene promoter activity

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An Sp1-binding silencer element is a critical negative regulator of the megakaryocyte-specific alphaIIb gene

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On the role of the general transcription factor Sp1 in the activation and repression of diverse mammalian oxidative phosphorylation genes

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Activation of the p21WAF1/CIP1 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through the Sp1 sites

1 reference

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Sodium butyrate induces transcription from the G alpha(i2) gene promoter through multiple Sp1 sites in the promoter and by activating the MEK-ERK signal transduction pathway

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Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism

1 reference

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Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif

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Telomere end-replication problem and cell aging

1 reference

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Toward identifying a cellular determinant of telomerase repression

1 reference

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The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase gene

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Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

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Identifiers

10.1074/JBC.M206064200

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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