Genotoxicity of streptozotocin (Q28216629)

Structure of streptozotocin

Europe PubMed Central

title

Genotoxicity of streptozotocin (English)

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1

Alejandro D Bolzán

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author name string

Martha S Bianchi

series ordinal

2

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language of work or name

English

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publication date

December 2002

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published in

Mutation Research

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volume

512

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issue

2-3

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page(s)

121-34

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cites work

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Chemotherapy with 5-Fluorouracil and Streptozotocin in Carcinoid Tumors of Gastrointestinal Origin: Experiences with 13 Patients

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Apurinic sites as mutagenic intermediates

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Streptozotocin and alloxan induce DNA strand breaks and poly(ADP–ribose) synthetase in pancreatic islets

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Comparative interactions of streptozotocin and chlorozotocin with DNA of an insulin-secreting cell line (RINr)

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Tissue-specific induction of mutations by streptozotocin in vivo.

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Extent and persistence of streptozotocin-induced DNA damage and cell proliferation in rat kidney as determined by in vivo alkaline elution and BrdUrd labeling assays

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Site-specific DNA methylation and apoptosis: induction by diabetogenic streptozotocin

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Measurement of unscheduled DNA synthesis in rat kidney cells following in vivo treatment with genotoxic agents

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7 January 2021

Genotoxicity of pancreatic chemical carcinogens to propagable cultured normal pancreatic epithelial cells

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Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro

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Effects of streptozotocin exposure in vitro on the replication and repair of DNA in fetal rat pancreatic islet cells

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Treatment of cultured pancreatic B-cells with streptozotocin induces cell death by apoptosis

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Sensitivity of HaCat keratinocytes to diabetogenic toxins

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Enhancement by streptozotocin of O2- radical generation by the xanthine oxidase system of pancreatic beta-cells

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Hydroxyl radical formation in diabetic rats induced by streptozotocin.

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N-monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA break formation in pancreatic rat islets

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7 January 2021

Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage.

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7 January 2021

Overexpression of metallothionein in pancreatic beta-cells reduces streptozotocin-induced DNA damage and diabetes

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7 January 2021

Protection against streptozotocin-induced diabetes by superoxide dismutase

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7 January 2021

Attenuation of streptozotocin diabetes with superoxide dismutase-like copper(II)(3,5-diisopropylsalicylate)2 in the rat

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7 January 2021

The partial protective effect of the hydroxyl radical scavenger dimethyl urea on streptozotocin-induced diabetes in the mouse in vivo and in vitro

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Modification of chemically induced diabetes in rats by vitamin E. Supplementation minimizes and depletion enhances development of diabetes

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The effects of N-methyl-N′-nitro-N-nitrosuguanidine and mutagen, streptozotocin on mammalian cell cultures

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Streptozotocin-induced chromosomal aberrations, SCEs and mutations in CHO-9 parental cells and in EM-C11 mutant cell line

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Effects of antioxidants on streptozotocin-induced clastogenesis in mammalian and insect cells

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The effect of 1,10-phenanthroline on the chromosome damage and sister-chromatid exchanges induced by streptozotocin in mammalian and insect cells

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Modulation of O6-alkylguanine alkyltransferase-directed DNA repair in metastatic colon cancers

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1,10 phenanthroline, a metal chelator, protects against alloxan- but not streptozotocin-induced diabetes

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Critical steps in alkylation-induced aberration formation

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Mutagenic activity of streptozotocin

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Mutagenicity testing of benomyl, methyl-2-benzimidazole carbamate, streptozotocin and N-methyl-N′-nitro-N-nitrosoguanidine in Salmonella typhimurium in vitro and in rodent host-mediated assays

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Induction of Renal Tumour by Streptozotocin in Rats

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Pancreatic islet cell tumors produced by the combined action of streptozotocin and nicotinamide

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Modification of Renal Tumorigenic Effect of Streptozotocin by Nicotinamide: Spontaneous Reversibility of Streptozotocin Diabetes

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Liver, kidney and islet cell tumors in spontaneously hypertensive and normotensive rats treated neonatally with streptozotocin

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Potential carcinogenic effect of streptozotocin.

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Effect of streptozotocin in the Chinese hamster (Cricetulus griseus)

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DNA damage induced by seven N-nitroso compounds in primary cultures of human and rat kidney cells

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Neoplastic transformation of propagable cultured rat pancreatic duct epithelial cells by azaserine and streptozotocin

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Potentiation of renal tumorigenicity by cyclosporine A in streptozotocin diabetic rats

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Amelioration of sodium barbital-induced nephropathy and regenerative tubular hyperplasia after a single injection of streptozotocin does not abolish the renal tumor promoting effect of barbital sodium in male F344/NC4 rats.

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7 January 2021