Modulation of O6-alkylating agent induced clastogenicity by enhanced DNA repair capacity of bone marrow cells (Q45889046)

17 December 2017

title

Modulation of O6-alkylating agent induced clastogenicity by enhanced DNA repair capacity of bone marrow cells (English)

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17 December 2017

author name string

N Chinnasamy

1

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17 December 2017

L J Fairbairn

2

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17 December 2017

J Laher

3

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17 December 2017

M A Willington

4

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17 December 2017

J A Rafferty

5

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17 December 2017

language of work or name

English

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publication date

1 August 1998

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17 December 2017

published in

Mutation Research

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17 December 2017

volume

416

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17 December 2017

issue

1-2

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17 December 2017

page(s)

1-10

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17 December 2017

DNA-repair methyltransferase as a molecular device for preventing mutation and cancer

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7 January 2021

Understanding and manipulating O6-methylguanine-DNA methyltransferase expression

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Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene

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7 January 2021

Expression of an E.coli O6-alkylguanine DNA alkyltransferase gene in Chinese hamster cells protects against N-methyl and N-ethylnitrosourea induced reverse mutation at the hypoxanthine phosphoribosyl transferase locus

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7 January 2021

Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

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7 January 2021

Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts

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7 January 2021

Relationship between O6-alkylguanine-DNA alkyltransferase activity and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation, transformation, and cytotoxicity in C3H/10T1/2 cells expressing exogenous alkyltransferase genes

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https://api.crossref.org/works/10.1016%2FS1383-5718%2898%2900087-4

7 January 2021

Chinese hamster cells harbouring the Escherichia coli O6-alkylguanine alkyltransferase gene are less susceptible to sister chromatid exchange induction and chromosome damage by methylating agents

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7 January 2021

Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines

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7 January 2021

The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase

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7 January 2021

Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent

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7 January 2021

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

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7 January 2021

Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells

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7 January 2021

Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone

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7 January 2021

Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea

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7 January 2021

Effect of single and multiple administration of an O6-benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model

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7 January 2021

Validation studies with Muta™ mouse: A transgenic mouse model for detecting mutations in vivo

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7 January 2021

Activity of the human carcinogen MeCCNU in the mouse bone marrow micronucleus assay

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7 January 2021

Clastogenicity to the mouse bone marrow of the mouse germ cell genotoxin streptozotocin

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7 January 2021

Potent clastogenicity of the human carcinogen etoposide to the mouse bone marrow and mouse lymphoma L5178Y cells: comparison to Salmonella responses.

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7 January 2021

The secondary leukemias: challenges and research directions

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7 January 2021

Incidence of second cancers in patients treated for Hodgkin's disease

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7 January 2021

Chemoprotection of normal tissues by transfer of drug resistance genes

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7 January 2021

Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent

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7 January 2021

Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine

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7 January 2021

Comparison of acridine orange and Giemsa stains in several mouse bone marrow micronucleus assays--including a triple dose study

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7 January 2021

Sex determination in single mouse blastomeres by polymerase chain reaction.

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7 January 2021

Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase.

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7 January 2021

Mutagenicity to Salmonella, Drosophila and the mouse bone marrow of the human antineoplastic agent fotemustine: prediction of carcinogenic potency.

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7 January 2021

Unexpected genetic toxicity to rodents of the N',N'-dimethyl analogues of MNU and ENU.

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7 January 2021

Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2898%2900087-4

7 January 2021

10.1016/S1383-5718(98)00087-4

Identifiers

DOI

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17 December 2017

PubMed ID

9725988

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17 December 2017