Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene (Q28217284)

1

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Linda Hibbert

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Nywana Sizemore

3

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George R Stark

Journal of Biological Chemistry

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language of work or name

English

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publication date

11 October 2002

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published in

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volume

277

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issue

41

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page(s)

38456-61

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cites work

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Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase

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The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein

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Interferon-dependent activation of the serine kinase PI 3'-kinase requires engagement of the IRS pathway but not the Stat pathway

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Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor

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Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase

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Phosphoinositide kinases

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Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

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Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase

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The role of phosphoinositide 3-kinase lipid products in cell function

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PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

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Interferon alpha /beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt.

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A Type I Interferon Signaling Factor, ISF21, Encoded on Chromosome 21 Is Distinct from Receptor Components and Their Down-regulation and Is Necessary for Transcriptional Activation of Interferon-regulated Genes

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A role for NF-kappa B in the induction of beta-R1 by interferon-beta

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The vav proto-oncogene product (p95vav) interacts with the Tyk-2 protein tyrosine kinase

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Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins

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