Structural based insights into the role of troponin in cardiac muscle pathophysiology (Q28235083)

Journal of Muscle Research & Cell Motility

Europe PubMed Central

title

Structural based insights into the role of troponin in cardiac muscle pathophysiology (English)

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Monica X Li

1

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Xu Wang

series ordinal

2

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Brian D Sykes

series ordinal

3

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language of work or name

English

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publication date

2004

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published in

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volume

25

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issue

7

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page(s)

559-79

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cites work

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Troponin I degradation and covalent complex formation accompanies myocardial ischemia/reperfusion injury

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Greater hydrogen ion-induced depression of tension and velocity in skinned single fibres of rat fast than slow muscles

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Effects of missense mutations Phe110Ile and Glu244Asp in human cardiac troponin T on force generation in skinned cardiac muscle fibers

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Ca2+, pH and the regulation of cardiac myofilament force and ATPase activity

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12 December 2020

Stepwise subunit interaction changes by mono- and bisphosphorylation of cardiac troponin I.

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12 December 2020

The effect of troponin I phosphorylation on the Ca2+-binding properties of the Ca2+-regulatory site of bovine cardiac troponin

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12 December 2020

First mutation in cardiac troponin C, L29Q, in a patient with hypertrophic cardiomyopathy

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12 December 2020

Can Förster resonance energy transfer measurements uniquely position troponin residues on the actin filament? A case study in multiple-acceptor FRET.

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12 December 2020

Molecular structure of troponin C from chicken skeletal muscle at 3-angstrom resolution

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12 December 2020

Binding of a new Ca2+ sensitizer, levosimendan, to recombinant human cardiac troponin C. A molecular modelling, fluorescence probe, and proton nuclear magnetic resonance study.

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12 December 2020

Interaction of bepridil with the cardiac troponin C/troponin I complex

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12 December 2020

Mechanism of action of Ca2+ sensitizers--update 2001.

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12 December 2020

Regulatory properties of the NH2- and COOH-terminal domains of troponin T. ATPase activation and binding to troponin I and troponin C

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12 December 2020

Transgenic mouse model of stunned myocardium

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12 December 2020

p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I.

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12 December 2020

Altered interactions among thin filament proteins modulate cardiac function

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12 December 2020

Identification of binding sites for bepridil and trifluoperazine on cardiac troponin C

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12 December 2020

Mapping of a second actin-tropomyosin and a second troponin C binding site within the C terminus of troponin I, and their importance in the Ca2+-dependent regulation of muscle contraction

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12 December 2020

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

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12 December 2020

Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity

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12 December 2020

A new look at thin filament regulation in vertebrate skeletal muscle.

1 reference

12 December 2020

Identification and mutagenesis of a highly conserved domain in troponin T responsible for troponin I binding: potential role for coiled coil interaction

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12 December 2020

The interaction of rabbit skeletal muscle troponin-T fragments with troponin-I

1 reference

12 December 2020

The troponin complex and regulation of muscle contraction

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12 December 2020

Regulation of contraction in striated muscle

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12 December 2020

Energetics of the induced structural change in a Ca2+ regulatory protein: Ca2+ and troponin I peptide binding to the E41A mutant of the N-domain of skeletal troponin C.

1 reference

12 December 2020

Cardiomyopathic tropomyosin mutations that increase thin filament Ca2+ sensitivity and tropomyosin N-domain flexibility

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12 December 2020

Solution structure of calcium-saturated cardiac troponin C bound to cardiac troponin I

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12 December 2020

Regulation of striated muscle contraction: a discussion

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12 December 2020

Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy

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12 December 2020

Chimera analysis of troponin I domains that influence Ca(2+)-activated myofilament tension in adult cardiac myocytes

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12 December 2020

Troponin I Inhibitory Peptide (96−115) Has an Extended Conformation When Bound to Skeletal Muscle Troponin C†

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12 December 2020

Single mutation (A162H) in human cardiac troponin I corrects acid pH sensitivity of Ca2+-regulated actomyosin S1 ATPase.

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12 December 2020

The troponin tail domain promotes a conformational state of the thin filament that suppresses myosin activity.

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12 December 2020

Improved mechanoenergetics and cardiac rest and reserve function of in vivo failing heart by calcium sensitizer EMD-57033

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12 December 2020

Familial hypertrophic cardiomyopathy mutations from different functional regions of troponin T result in different effects on the pH and Ca2+ sensitivity of cardiac muscle contraction

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12 December 2020

Cardiovascular profile of the calcium sensitizer EMD 57033 in open-chest anaesthetized pigs with regionally stunned myocardium

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12 December 2020

Conformational changes of troponin C within the thin filaments detected by neutron scattering

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12 December 2020

Troponin I: inhibitor or facilitator

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12 December 2020

Systematic mapping of regions of human cardiac troponin I involved in binding to cardiac troponin C: N- and C-terminal low affinity contributing regions

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12 December 2020

Troponin and tropomyosin: proteins that switch on and tune in the activity of cardiac myofilaments

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12 December 2020

Positive inotropic effects of calcium sensitizers on normal and failing cardiac myocytes

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12 December 2020

Interplay of troponin- and Myosin-based pathways of calcium activation in skeletal and cardiac muscle: the use of W7 as an inhibitor of thin filament activation

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12 December 2020

Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T

1 reference

12 December 2020

Identification of a region of fast skeletal troponin T required for stabilization of the coiled-coil formation with troponin I

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12 December 2020

Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy

1 reference

12 December 2020

A model of troponin-I in complex with troponin-C using hybrid experimental data: the inhibitory region is a beta-hairpin

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12 December 2020

Molecular cloning of human cardiac troponin T isoforms: expression in developing and failing heart.

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12 December 2020

Solution structures of the C-terminal domain of cardiac troponin C free and bound to the N-terminal domain of cardiac troponin I

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12 December 2020

Calcium-induced structural transition in the regulatory domain of human cardiac troponin C

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12 December 2020

Conformation of the regulatory domain of cardiac muscle troponin C in its complex with cardiac troponin I.

1 reference

12 December 2020

Augmented systolic response to the calcium sensitizer EMD-57033 in a transgenic model with troponin I truncation

1 reference

12 December 2020

Different functional properties of troponin T mutants that cause dilated cardiomyopathy

1 reference

12 December 2020

Phosphorylation and mutation of human cardiac troponin I deferentially destabilize the interaction of the functional regions of troponin I with troponin C.

1 reference

12 December 2020

Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy

1 reference

12 December 2020

Phosphorylation of human cardiac troponin I G203S and K206Q linked to familial hypertrophic cardiomyopathy affects actomyosin interaction in different ways

1 reference

12 December 2020

Structure, dynamics, and thermodynamics of the structural domain of troponin C in complex with the regulatory peptide 1-40 of troponin I

1 reference

12 December 2020

NMR structure of a bifunctional rhodamine labeled N-domain of troponin C complexed with the regulatory "switch" peptide from troponin I: implications for in situ fluorescence studies in muscle fibers

1 reference

12 December 2020

Structures of four Ca2+-bound troponin C at 2.0 A resolution: further insights into the Ca2+-switch in the calmodulin superfamily

1 reference

12 December 2020

Functional consequences of a carboxyl terminal missense mutation Arg278Cys in human cardiac troponin T

1 reference

12 December 2020

Two site binding of bepridil and modulation of adenylate cyclase in cardiac sarcolemmal membranes

1 reference

12 December 2020

Structure of the inhibitory region of troponin by site directed spin labeling electron paramagnetic resonance

1 reference

12 December 2020

Effects of troponin I phosphorylation on conformational exchange in the regulatory domain of cardiac troponin C

1 reference

12 December 2020

Troponin I isoforms and chimeras: tuning the molecular switch of cardiac contraction.

1 reference

12 December 2020

Altered cardiac troponin T in vitro function in the presence of a mutation implicated in familial hypertrophic cardiomyopathy

1 reference

12 December 2020

Mechanisms of acute ischemic contractile failure of the heart. Role of intracellular calcium

1 reference

12 December 2020

Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere

1 reference

12 December 2020

Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants

1 reference

12 December 2020

The solution structure of a cardiac troponin C-troponin I-troponin T complex shows a somewhat compact troponin C interacting with an extended troponin I-troponin T component

1 reference

12 December 2020

Calcium sensitizer EMD 57033, but not the beta1-adrenoreceptor agonist dobutamine, increases mechanical efficiency in stunned myocardium

1 reference

12 December 2020

Molecular actions of drugs that sensitize cardiac myofilaments to Ca2+.

1 reference

12 December 2020

Functional analyses of troponin T mutations that cause hypertrophic cardiomyopathy: insights into disease pathogenesis and troponin function

1 reference

12 December 2020

Characterization of the interaction between the N-terminal extension of human cardiac troponin I and troponin C.

1 reference

12 December 2020

Lessons from old and new kinases

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12 December 2020

Modulation of cardiac troponin C-cardiac troponin I regulatory interactions by the amino-terminus of cardiac troponin I

1 reference

12 December 2020

Drug binding to cardiac troponin C

1 reference

12 December 2020

The Two Mechanisms of Action of Racemic Cardiotonic EMD 53998, Calcium Sensitization and Phosphodiesterase Inhibition, Reside in Different Enantiomers

1 reference

12 December 2020

Stimulation of cardiac myofilament force, ATPase activity and troponin C Ca++ binding by bepridil

1 reference

12 December 2020

Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations

1 reference

12 December 2020

NMR analysis of cardiac troponin C-troponin I complexes: effects of phosphorylation

1 reference

12 December 2020

Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033

1 reference

12 December 2020

Structures of the troponin C regulatory domains in the apo and calcium-saturated states

1 reference

12 December 2020

Effects of T142 phosphorylation and mutation R145G on the interaction of the inhibitory region of human cardiac troponin I with the C-domain of human cardiac troponin C

1 reference

12 December 2020

The ordered phosphorylation of cardiac troponin I by the cAMP-dependent protein kinase--structural consequences and functional implications

1 reference

12 December 2020

Mapping the domain of troponin T responsible for the activation of actomyosin ATPase activity. Identification of residues involved in binding to actin

1 reference

12 December 2020

Phosphorylation of troponin I by protein kinase A accelerates relaxation and crossbridge cycle kinetics in mouse ventricular muscle

1 reference

12 December 2020

Photocrosslinking of benzophenone-labeled single cysteine troponin I mutants to other thin filament proteins

1 reference

12 December 2020

The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms

1 reference

12 December 2020

Interaction of troponin I and troponin C. Use of the two-dimensional nuclear magnetic resonance transferred nuclear Overhauser effect to determine the structure of the inhibitory troponin I peptide when bound to skeletal troponin C

1 reference

12 December 2020

In Situ Orientations of Protein Domains

1 reference

12 December 2020

Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy

1 reference

12 December 2020

Thin filament-mediated regulation of cardiac contraction

1 reference

12 December 2020

Interactions at the NH2-terminal interface of cardiac troponin I modulate myofilament activation

1 reference

12 December 2020

Effects of protein kinase C dependent phosphorylation and a familial hypertrophic cardiomyopathy-related mutation of cardiac troponin I on structural transition of troponin C and myofilament activation

1 reference

12 December 2020

Structure of the Mg2+-loaded C-lobe of cardiac troponin C bound to the N-domain of cardiac troponin I: comparison with the Ca2+-loaded structure

1 reference

12 December 2020

Another new kinase targets troponin I.

1 reference

12 December 2020

Overall cardiac functional effect of positive inotropic drugs with differing effects on relaxation

1 reference

12 December 2020

Structural consequences of cardiac troponin I phosphorylation

1 reference

12 December 2020

A cross-linking study of the N-terminal extension of human cardiac troponin I.

1 reference

12 December 2020

A novel mutation Lys273Glu in the cardiac troponin T gene shows high degree of penetrance and transition from hypertrophic to dilated cardiomyopathy

1 reference

12 December 2020

Effects of phosphorylation and mutation R145G on human cardiac troponin I function.

1 reference

12 December 2020

NMR solution structure of calcium-saturated skeletal muscle troponin C

1 reference

12 December 2020

Role of troponin I phosphorylation in protein kinase C-mediated enhanced contractile performance of rat myocytes

1 reference

12 December 2020

Small-angle neutron scattering with contrast variation reveals spatial relationships between the three subunits in the ternary cardiac troponin complex and the effects of troponin I phosphorylation

1 reference

12 December 2020

In vivo evidence of positive inotropism of EMD 57033 through calcium sensitization.

1 reference

12 December 2020

Binding of levosimendan, a calcium sensitizer, to cardiac troponin C.

1 reference

12 December 2020

Structure of Cardiac Muscle Troponin C Unexpectedly Reveals a Closed Regulatory Domain

1 reference

12 December 2020

Bepridil opens the regulatory N-terminal lobe of cardiac troponin C

1 reference

12 December 2020

Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties

1 reference

12 December 2020

Molecular and integrated biology of thin filament protein phosphorylation in heart muscle

1 reference

12 December 2020

Altered signaling surrounding the C-lobe of cardiac troponin C in myofilaments containing an α-tropomyosin mutation linked to familial hypertrophic cardiomyopathy

1 reference

12 December 2020

Molecular and cellular aspects of troponin cardiomyopathies

1 reference

12 December 2020

Equilibrium unfolding and conformational plasticity of troponin I and T.

1 reference

12 December 2020

Interaction of the second binding region of troponin I with the regulatory domain of skeletal muscle troponin C as determined by NMR spectroscopy

1 reference

12 December 2020

Slow skeletal troponin I gene transfer, expression, and myofilament incorporation enhances adult cardiac myocyte contractile function

1 reference

12 December 2020

Effects of protein kinase A phosphorylation on signaling between cardiac troponin I and the N-terminal domain of cardiac troponin C

1 reference

12 December 2020

Phosphorylation-induced distance change in a cardiac muscle troponin I mutant.

1 reference

12 December 2020

Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation.

1 reference

12 December 2020

Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy

1 reference

12 December 2020

Patients with familial hypertrophic cardiomyopathy caused by a Phe110Ile missense mutation in the cardiac troponin T gene have variable cardiac morphologies and a favorable prognosis

1 reference

12 December 2020

Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

1 reference

12 December 2020

In vivo evidence that EMD 57033 restores myocardial responsiveness to intracoronary Ca(2+) in stunned myocardium

1 reference

12 December 2020

Binding of a calcium sensitizer, bepridil, to cardiac troponin C. A fluorescence stopped-flow kinetic, circular dichroism, and proton nuclear magnetic resonance study

1 reference

12 December 2020

Molecular mechanism of levosimendan action: an update

1 reference

12 December 2020

Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C

1 reference

12 December 2020

Mapping the interacting regions between troponins T and C. Binding of TnT and TnI peptides to TnC and NMR mapping of the TnT-binding site on TnC

1 reference

12 December 2020

Interaction of levosimendan with cardiac troponin C in the presence of cardiac troponin I peptides

1 reference

12 December 2020

Localization of regions of troponin I important in deactivation of cardiac myofilaments by acidic pH

1 reference

12 December 2020

The amino acid sequence of bovine cardiac tamponin-C. Comparison with rabbit skeletal troponin-C

1 reference

12 December 2020

Switching of troponin I: Ca(2+) and myosin-induced activation of heart muscle

1 reference

12 December 2020

Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy

1 reference

12 December 2020

Two trifluoperazine-binding sites on calmodulin predicted from comparative molecular modeling with troponin-C

1 reference

12 December 2020

Interaction of cardiac troponin C with Ca(2+) sensitizer EMD 57033 and cardiac troponin I inhibitory peptide

1 reference

12 December 2020

Functional consequences of troponin T mutations found in hypertrophic cardiomyopathy

1 reference

12 December 2020

Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy.

1 reference

12 December 2020

Ca2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy

1 reference

12 December 2020

Structure and Dynamics of the C-domain of Human Cardiac Troponin C in Complex with the Inhibitory Region of Human Cardiac Troponin I

1 reference

12 December 2020

Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy

1 reference

12 December 2020

Stereoselective actions of thiadiazinones on canine cardiac myocytes and myofilaments

1 reference

12 December 2020

Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution

1 reference

12 December 2020

Calcium, thin filaments, and the integrative biology of cardiac contractility

1 reference

12 December 2020

Structure of the calcium regulatory muscle protein troponin-C at 2.8 Å resolution

1 reference

12 December 2020

Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin T

1 reference

12 December 2020

The NMR angle on troponin C

1 reference

12 December 2020

Expression of slow skeletal troponin I in adult transgenic mouse heart muscle reduces the force decline observed during acidic conditions

1 reference

12 December 2020

Troponin T: genetics, properties and function

1 reference

12 December 2020

Solution structure and main chain dynamics of the regulatory domain (Residues 1-91) of human cardiac troponin C.

1 reference

12 December 2020

The effect of regulatory Ca2+ on the in situ structures of troponin C and troponin I: a neutron scattering study

1 reference

12 December 2020

Invited Review: pathophysiology of cardiac muscle contraction and relaxation as a result of alterations in thin filament regulation

1 reference

12 December 2020

Transgenic modeling of a cardiac troponin I mutation linked to familial hypertrophic cardiomyopathy

1 reference

12 December 2020

Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil

1 reference

12 December 2020

Interaction of cardiotonic thiadiazinone derivatives with cardiac troponin C

1 reference

12 December 2020

Novel cardiac troponin T mutation as a cause of familial dilated cardiomyopathy

1 reference

12 December 2020

The Genetic Basis for Cardiomyopathy

1 reference

12 December 2020