Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells (Q28235590)

1

0 references

Inbal Dar

2

0 references

Leonid Mittelman

3

0 references

Yaron Pereg

4

0 references

Ari Barzilai

5

0 references

Yosef Shiloh

Journal of Biological Chemistry

6

0 references

language of work or name

English

0 references

publication date

23 June 2006

0 references

published in

0 references

volume

281

0 references

issue

25

0 references

page(s)

17482-91

0 references

cites work

Ataxia-telangiectasia, an evolving phenotype

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

21 January 2018

Ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Quantitative neurologic assessment of ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Initiating cellular stress responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

ATM immunolocalization in mouse neuronal endosomes: implications for ataxia-telangiectasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Characterization of the cholinergic neuronal differentiation of the human neuroblastoma cell line LA-N-5 after treatment with retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Neuritogenesis induced by vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, and peptide histidine methionine in SH-SY5y cells is associated with regulated expression of cytoskeleton mRNAs and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Neuroblastoma cell lines--a versatile in vitro model in neurobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

p27Kip1 accumulation is associated with retinoic-induced neuroblastoma differentiation: evidence of a decreased proteasome-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Differentiation and survival influences of growth factors in human neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Differentiation of LA-N-5 neuroblastoma cells into cholinergic neurons: methods for differentiation, immunohistochemistry and reporter gene introduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Requirement of b-myb function for survival and differentiative potential of human neuroblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Retinoblastoma family proteins induce differentiation and regulate B-myb expression in neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Ataxia telangiectasia mutated is essential during adult neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Regulation of DNA replication by ATR: signaling in response to DNA intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

DNA single-strand breaks and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Aprataxin, a novel protein that protects against genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

The novel human gene aprataxin is directly involved in DNA single-strand-break repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Silencing and variegation of gammaretrovirus and lentivirus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Retrovirus silencing and vector design: relevance to normal and cancer stem cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Expression of DNA-dependent protein kinase catalytic subunit and Ku80 in developing human brains: implication of DNA-repair in neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Expression pattern of the Nijmegen breakage syndrome gene, Nbs1, during murine development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

To die or not to die: DNA repair in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

DNA repair in terminally differentiated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Is DNA repair compromised in Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Localization of a portion of extranuclear ATM to peroxisomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Differentiation-induced radioresistance in muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

21 January 2018

The Chk2 protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Cell cycle activation linked to neuronal cell death initiated by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Divide and die: cell cycle events as triggers of nerve cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Oxidative stress, cell cycle, and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Ataxia telangiectasia: new neurons and ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

ATM dependent apoptosis in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Contribution of the Atm protein to maintaining cellular homeostasis evidenced by continuous activation of the AP-1 pathway in Atm-deficient brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

DNA repair in neural cells: basic science and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

The DNA double-strand break response in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Linking DNA damage and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Atm-deficient mice: a paradigm of ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

An essential function for NBS1 in the prevention of ataxia and cerebellar defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Nbs1 is required for ATR-dependent phosphorylation events

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Role of DNA-PK in the cellular response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

H2AX: the histone guardian of the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

21 January 2018

Maintaining integrity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

Improved immunodetection of nuclear antigens after sodium dodecyl sulfate treatment of formaldehyde-fixed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200

53BP1, an activator of ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601895200