Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+ (Q28240502)

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18 March 2020

title

Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+ (English)

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18 March 2020

1

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18 March 2020

Andy K M Lam

2

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18 March 2020

Antony Giuseppe Galione

4

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18 March 2020

author name string

Katja Rietdorf

3

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18 March 2020

Rebecca Sitsapesan

5

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18 March 2020

language of work or name

English

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publication date

20 May 2014

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18 March 2020

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18 March 2020

volume

7

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18 March 2020

issue

326

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18 March 2020

page(s)

ra46

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NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs

18 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2004854

NAADP mobilizes calcium from acidic organelles through two-pore channels

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2004854

The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2004854

An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2004854

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2004854

An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2004854

Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2004854

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2004854

Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2004854

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2004854

Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2004854

TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2004854

Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2004854

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2004854

NAADP: a universal Ca2+ trigger

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Two-pore channels for integrative Ca signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Calcium signaling via two-pore channels: local or global, that is the question

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

TPC1-SV channels gain shape

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Sea urchin eggs in the acid reign

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

NAADP induces pH changes in the lumen of acidic Ca2+ stores

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

NAADP influences excitation-contraction coupling by releasing calcium from lysosomes in atrial myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Alpha-helical hydrophobic polypeptides form proton-selective channels in lipid bilayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Proton conductance of influenza virus M2 protein in planar lipid bilayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Calcium uptake via endocytosis with rapid release from acidifying endosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

A cation counterflux supports lysosomal acidification

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Regulation of organelle acidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Steady-state coupling of ion-channel conformations to a transmembrane ion gradient

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Chloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Influence of permeant ions on gating in cyclic nucleotide-gated channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Calcium-Activated K+ Channels and Calcium-Induced Calcium Release by Slow Vacuolar Ion Channels in Guard Cell Vacuoles Implicated in the Control of Stomatal Closure

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

A putative two pore channel AtTPC1 mediates Ca(2+) flux in Arabidopsis leaf cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Nicotinic acid adenine dinucleotide phosphate (NAADP) activates global and heterogeneous local Ca2+ signals from NAADP- and ryanodine receptor-gated Ca2+ stores in pulmonary arterial myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Cyclic adenosine diphosphate ribose activates ryanodine receptors, whereas NAADP activates two-pore domain channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

Expression of the voltage-gated sodium channel NaV1.5 in the macrophage late endosome regulates endosomal acidification

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

The effect of sodium ions on the electrical activity of the giant axon of the squid

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004854

The ionic requirements for the production of action potentials in crustacean muscle fibres

21 January 2018

1 reference

12 December 2020

Sheep cardiac sarcoplasmic reticulum calcium-release channels: modification of conductance and gating by temperature

1 reference

12 December 2020

NAADP as an intracellular messenger regulating lysosomal calcium-release channels

1 reference

12 December 2020

In situ measurement of the electrical potential across the lysosomal membrane using FRET

1 reference

12 December 2020

Permeant cations alter endplate channel characteristics

1 reference

12 December 2020

The lysosomal proton pump is electrogenic

1 reference

12 December 2020

ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP

1 reference

12 December 2020

Modulation of Ca(2+)-gated cardiac muscle Ca(2+)-release channel (ryanodine receptor) by mono- and divalent ions

1 reference

12 December 2020

10.1126/SCISIGNAL.2004854

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

4502341

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847115%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

4502341

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847115%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

PubMed publication ID

24847115

2 references

Consolidated OpenCitations Corpus – April 2017

4502341