Tackling heart failure in the twenty-first century (Q37089726)

18 August 2017

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title

Tackling heart failure in the twenty-first century (English)

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18 August 2017

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James O Mudd

1

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18 August 2017

David A Kass

series ordinal

2

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18 August 2017

language of work or name

English

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publication date

1 February 2008

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18 August 2017

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18 August 2017

451

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18 August 2017

7181

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18 August 2017

919-928

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https://scigraph.springernature.com/pub.10.1038/nature06798

18 August 2017

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cites work

Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure

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https://api.crossref.org/works/10.1038%2FNATURE06798

Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE06798

Altered cardiac myocyte Ca regulation in heart failure.

21 January 2018

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A XII century description of congestive heart failure.

21 January 2018

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7 January 2021

Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group

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https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure

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https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes

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https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Type 5 adenylyl cyclase disruption increases longevity and protects against stress

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Regulation of cardiac hypertrophy by intracellular signalling pathways

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators

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7 January 2021

Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Effect of carvedilol on survival in severe chronic heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Beta-adrenoceptor blocker treatment and the cardiac beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in chronic heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL).

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Acute phosphodiesterase 5 inhibition mimics hemodynamic effects of B-type natriuretic peptide and potentiates B-type natriuretic peptide effects in failing but not normal canine heart.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Genetic causes of human heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Sex- and age-dependent human transcriptome variability: implications for chronic heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Combination of isosorbide dinitrate and hydralazine in blacks with heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Calmodulin kinase II inhibition protects against structural heart disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

PKC-alpha regulates cardiac contractility and propensity toward heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Inhibition of glycogen synthase kinase 3beta during heart failure is protective

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Stressing the role of FoxO proteins in lifespan and disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Function of cGMP-dependent protein kinases as revealed by gene deletion.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Phosphodiesterase type 5: expanding roles in cardiovascular regulation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte Viability

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

MicroRNA-133 controls cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Control of stress-dependent cardiac growth and gene expression by a microRNA

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Silencing of microRNAs in vivo with 'antagomirs'

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Role of oxidative stress in cardiac hypertrophy and remodeling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Death begets failure in the heart

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

A mechanistic role for cardiac myocyte apoptosis in heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Many good reasons to have STAT3 in the heart

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Cardiac autophagy is a maladaptive response to hemodynamic stress

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Upregulation of TRPC1 in the development of cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Alterations in energy metabolism in cardiomyopathies

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Modification of myocardial substrate use as a therapy for heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

ATP flux through creatine kinase in the normal, stressed, and failing human heart

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

The giant protein titin: a major player in myocardial mechanics, signaling, and disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Mechanisms and use of calcium-sensitizing agents in the failing heart

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Pathobiology of left ventricular dyssynchrony and resynchronization

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Chronic unloading by left ventricular assist device reverses contractile dysfunction and alters gene expression in end-stage heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Left ventricular assist device and drug therapy for the reversal of heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Therapy with cardiac contractility modulation electrical signals improves left ventricular function and remodeling in dogs with chronic heart failure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06798

7 January 2021

Identifiers

DOI

10.1038/NATURE06798

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Dimensions Publication ID

18 August 2017

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