Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock (Q28244377)

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object named as

Tom van der Poll

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Dirk Foell

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object named as

Dirk Foell

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Wolfgang Nacken

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object named as

Wolfgang Nacken

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author name string

Thomas Vogl

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Klaus Tenbrock

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Nadja Leukert

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Christina Ehrhardt

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Marieke A D van Zoelen

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Clemens Sorg

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Johannes Roth

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language of work or name

English

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publication date

September 2007

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published in

Nature Medicine

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volume

13

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page(s)

1042-9

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issue

9

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1 reference

7 January 2021

Innate immune sensing and its roots: the story of endotoxin

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7 January 2021

Toll-like receptor signalling

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7 January 2021

Therapeutics targeting the innate immune system

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7 January 2021

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

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7 January 2021

Roles of heat-shock proteins in innate and adaptive immunity

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Endogenous ligands of Toll-like receptors

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Therapeutic approaches to innate immunity: severe sepsis and septic shock

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7 January 2021

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

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Proinflammatory S100 proteins in arthritis and autoimmune disease

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7 January 2021

Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules

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7 January 2021

Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis

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7 January 2021

Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 detected by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry

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7 January 2021

MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes

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7 January 2021

Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro

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7 January 2021

Myeloid cell function in MRP-14 (S100A9) null mice

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Polyethylenimine, a cost-effective transfection reagent

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7 January 2021

Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway

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7 January 2021

Galactosamine-induced sensitization to the lethal effects of endotoxin

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7 January 2021

Hyperzincaemia and hypercalprotectinaemia: a new disorder of zinc metabolism.

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7 January 2021

Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice

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7 January 2021

Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection

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7 January 2021

Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact

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7 January 2021

Characterization of tumor necrosis factor-deficient mice

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7 January 2021

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

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7 January 2021

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

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7 January 2021

The tolls of arthritis

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7 January 2021

RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides

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7 January 2021

Absence of S100A12 in mouse: implications for RAGE-S100A12 interaction

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7 January 2021

Effect of a chimeric antibody to tumor necrosis factor-alpha on cytokine and physiologic responses in patients with severe sepsis--a randomized, clinical trial.

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7 January 2021

Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group

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7 January 2021

Blockade of S100A8 and S100A9 suppresses neutrophil migration in response to lipopolysaccharide

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7 January 2021

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

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7 January 2021

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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7 January 2021

High level expression and dimer characterization of the S100 EF-hand proteins, migration inhibitory factor-related proteins 8 and 14.

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7 January 2021

Transcriptional profiling of IKK2/NF-kappa B- and p38 MAP kinase-dependent gene expression in TNF-alpha-stimulated primary human endothelial cells

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7 January 2021

The cyclic adenosine 5'-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism

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7 January 2021

Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma : a molecular basis for priming and synergism with bacterial lipopolysaccharide

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7 January 2021

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

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7 January 2021

Biochemical characterization of the murine S100A9 (MRP14) protein suggests that it is functionally equivalent to its human counterpart despite its low degree of sequence homology

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7 January 2021