Therapeutics targeting the innate immune system (Q35824051)

10 August 2017

1 reference

title

Therapeutics targeting the innate immune system (English)

1 reference

10 August 2017

Richard J Ulevitch

1

1 reference

10 August 2017

publication date

1 July 2004

1 reference

Nature Reviews Immunology

10 August 2017

published in

1 reference

10 August 2017

volume

4

1 reference

10 August 2017

issue

7

1 reference

10 August 2017

page(s)

512-520

1 reference

Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin

10 August 2017

cites work

1 reference

Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes

21 January 2018

1 reference

Toll-like receptor 3: a link between toll-like receptor, interferon and viruses

21 January 2018

1 reference

Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells

21 January 2018

1 reference

CpG-DNA aided cross-priming by cross-presenting B cells

21 January 2018

1 reference

TIR domain-containing adaptors define the specificity of TLR signaling

21 January 2018

1 reference

How we detect microbes and respond to them: the Toll-like receptors and their transducers

31 March 2020

1 reference

Toll-like receptors: networking for success.

31 March 2020

1 reference

The role of MyD88-like adapters in Toll-like receptor signal transduction

31 March 2020

1 reference

31 March 2020

1 reference

Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation

31 March 2020

1 reference

NODs: intracellular proteins involved in inflammation and apoptosis

31 March 2020

1 reference

Toll-like receptor signalling

31 March 2020

1 reference

Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.

31 March 2020

1 reference

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

31 March 2020

1 reference

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

31 March 2020

1 reference

Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family

31 March 2020

1 reference

The Toll-IL-1 receptor adaptor family grows to five members.

31 March 2020

1 reference

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

31 March 2020

1 reference

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

31 March 2020

1 reference

The immune response of Drosophila

31 March 2020

1 reference

Dual activation of the Drosophila toll pathway by two pattern recognition receptors

31 March 2020

1 reference

Toll signaling: the TIReless quest for specificity

31 March 2020

1 reference

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein

31 March 2020

1 reference

A toll-like receptor that prevents infection by uropathogenic bacteria

31 March 2020

1 reference

Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors

31 March 2020

1 reference

Endotoxin recognition molecules, Toll-like receptor 4-MD-2.

31 March 2020

1 reference

Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14.

31 March 2020

1 reference

The role of Toll-like receptor 2 in microbial disease and immunity

31 March 2020

1 reference

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

31 March 2020

1 reference

Plant immunity: the origami of receptor activation

31 March 2020

1 reference

Recognition and Response in the Plant Immune System

31 March 2020

1 reference

Understanding the functions of plant disease resistance proteins

31 March 2020

1 reference

Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases

31 March 2020

1 reference

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

31 March 2020

1 reference

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells

31 March 2020

1 reference

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.

31 March 2020

1 reference

Regulation of dendritic cell function through Toll-like receptors

31 March 2020

1 reference

T cell activation, from atopy to asthma: more a paradox than a paradigm.

31 March 2020

1 reference

CpG oligodeoxynucleotides: a novel therapeutic approach for atopic disorders.

31 March 2020

1 reference

The TIM gene family: emerging roles in immunity and disease

31 March 2020

1 reference

Strategies for immunotherapy of cancer

31 March 2020

1 reference

Exploiting the immune system: toward new vaccines against intracellular bacteria

31 March 2020

1 reference

Toll-like receptors as adjuvant receptors

31 March 2020

1 reference

Synthetic vaccines: the role of adjuvants in immune targeting

31 March 2020

1 reference

Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi.529.

31 March 2020

1 reference

Taking toll: lipid A mimetics as adjuvants and immunomodulators

31 March 2020

1 reference

Structure-activity relationship of synthetic toll-like receptor 4 agonists

31 March 2020

1 reference

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

31 March 2020

1 reference

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

31 March 2020

1 reference

31 March 2020

1 reference

Topical immunomodulators for the treatment of external genital warts, cutaneous warts and molluscum contagiosum

31 March 2020

1 reference

Established and potential strategies against papillomavirus infections

31 March 2020

1 reference

Recognition of pathogen-associated molecular patterns by TLR family

31 March 2020

1 reference

The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

31 March 2020

1 reference

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

31 March 2020

1 reference

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

31 March 2020

1 reference

IRF3 mediates a TLR3/TLR4-specific antiviral gene program

31 March 2020

1 reference

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

31 March 2020

1 reference

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

31 March 2020

1 reference

Lps2 and signal transduction in sepsis: at the intersection of host responses to bacteria and viruses

31 March 2020

1 reference

Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection

31 March 2020

1 reference

Allergen-immunostimulatory oligodeoxynucleotide conjugate: a novel allergoid for immunotherapy

31 March 2020

1 reference

The IKK NF-kappa B system: a treasure trove for drug development

31 March 2020

1 reference

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

31 March 2020

1 reference

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

31 March 2020

1 reference

A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses

31 March 2020

1 reference

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

31 March 2020

1 reference

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

31 March 2020

1 reference

Unresponsiveness of MyD88-deficient mice to endotoxin

31 March 2020

1 reference

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

31 March 2020

1 reference

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

31 March 2020

1 reference

Efficacy and tolerability of short-term specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A (MPL) for children and adolescents

31 March 2020

1 reference

Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies.

31 March 2020

1 reference

Effect of monophosphoryl lipid A (MPL) on T-helper cells when administered as an adjuvant with pneumocococcal-CRM197 conjugate vaccine in healthy toddlers

31 March 2020

1 reference

Extended in Vivo Pharmacodynamic Activity of E5564 in Normal Volunteers with Experimental Endotoxemia

31 March 2020

1 reference

Pharmacokinetics of E5564, a Lipopolysaccharide Antagonist, in Patients with Impaired Hepatic Function

31 March 2020

1 reference

Phase 1, randomized, double-blind trial of 7-allyl-8-oxoguanosine (loxoribine) in advanced cancer

31 March 2020

1 reference

Randomized, single-blind, placebo-controlled study of topical application of the immune response modulator resiquimod in healthy adults

31 March 2020

1 reference

Treatment of Bowen's disease with imiquimod 5% cream in transplant recipients

31 March 2020

1 reference

Treatment of anal intraepithelial neoplasia in patients with acquired HIV with imiquimod 5% cream

31 March 2020

1 reference

Imiquimod and the treatment of cutaneous T-cell proliferative diseases: at the threshold

31 March 2020

1 reference

Heterogeneity in the human response to immunostimulatory CpG oligodeoxynucleotides

31 March 2020

1 reference

Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response

31 March 2020

1 reference

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI1396

1 reference

10 August 2017

1 reference