Roles for CCN2 in normal physiological processes (Q28246114)

Cellular and Molecular Life Sciences

Europe PubMed Central

title

Roles for CCN2 in normal physiological processes (English)

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Faith Hall-Glenn

1

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Karen M Lyons

series ordinal

2

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language of work or name

English

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publication date

October 2011

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published in

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volume

68

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issue

19

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page(s)

3209-17

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exact match

https://scigraph.springernature.com/pub.10.1007/s00018-011-0782-7

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cites work

CCN2 is required for bleomycin-induced skin fibrosis in mice

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Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis

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N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan

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Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis

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All in the CCN family: essential matricellular signaling modulators emerge from the bunker

20 March 2017

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CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells

20 March 2017

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Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan

20 March 2017

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Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development

20 March 2017

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Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165

20 March 2017

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Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model

20 March 2017

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Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo

20 March 2017

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The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling

20 March 2017

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Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

20 March 2017

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Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload

20 March 2017

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Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage

20 March 2017

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Pericyte loss and microaneurysm formation in PDGF-B-deficient mice

20 March 2017

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Developmental regulation of the growth plate

7 April 2017

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CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasia

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29 September 2017

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A mouse strain where basal connective tissue growth factor gene expression can be switched from low to high

29 September 2017

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Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β.

29 September 2017

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CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model

29 September 2017

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Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

29 September 2017

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Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin

29 September 2017

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Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice

29 September 2017

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Temporal and spatial expression of CCN genes in zebrafish

29 September 2017

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Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes

29 September 2017

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Conditional overexpression of connective tissue growth factor disrupts postnatal lung development

29 September 2017

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Role of CCN, a vertebrate specific gene family, in development

29 September 2017

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CTGF inhibits BMP-7 signaling in diabetic nephropathy

29 September 2017

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CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice

29 September 2017

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Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis

29 September 2017

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Fetal growth plate: a developmental model of cellular adaptation to hypoxia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Hypoxia and osteoarthritis: how chondrocytes survive hypoxic environments

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Microarray analysis of Myf5-/-:MyoD-/- hypoplastic mouse lungs reveals a profile of genes involved in pneumocyte differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

The physiological role of CTGF/CCN2 in zebrafish notochond development and biological analysis of the proximal promoter region

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Regulation of PDGF and its receptors in fibrotic diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Wise, a context-dependent activator and inhibitor of Wnt signalling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Contractile protein phenotypic variation during development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

The modular architecture of a new family of growth regulators related to connective tissue growth factor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Functional requirement of CCN2 for intramembranous bone formation in embryonic mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Binding properties of insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-3 N- and C-terminal fragments, and structurally related proteins mac25 and connective tissue growth factor measured using a biosensor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Localization of connective tissue growth factor during the period of embryo implantation in the mouse

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Adenoviral gene transfer of connective tissue growth factor in the lung induces transient fibrosis.

2 June 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0782-7

Connective tissue growth factor is crucial to inducing a profibrotic environment in "fibrosis-resistant" BALB/c mouse lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0782-7

Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0782-7

Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0782-7

Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

CTGF expression during mouse embryonic development

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3670951

Immunohistochemical localization of connective tissue growth factor (CTGF) in the mouse embryo between days 7.5 and 14.5 of gestation

27 November 2018

1 reference

12 December 2020

Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo

1 reference

12 December 2020

CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes

1 reference

12 December 2020

Connective tissue growth factor mRNA expression pattern in cartilages is associated with their type I collagen expression

1 reference

12 December 2020

Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice

1 reference

12 December 2020

Connective tissue growth factor/CCN2 overexpression in mouse synovial lining results in transient fibrosis and cartilage damage

1 reference

12 December 2020

Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction

1 reference

12 December 2020

Gene expression of connective tissue growth factor in adult mouse

1 reference

12 December 2020

10.1007/S00018-011-0782-7

Identifiers

DOI

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3563112

3563112

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1 reference

1 reference