Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12 (Q28246158)

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12 March 2020

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8 February 2021

Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12 (English)

1 reference

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12 March 2020

main subject

pulmonary hypertension

1 reference

14 September 2020

endothelin receptor B

1 reference

aspartic acid endopeptidases

31 July 2019

1 reference

endothelin A receptor antagonists

28 September 2019

1 reference

2 October 2019

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20 November 2019

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14 September 2020

1 reference

3 December 2020

1 reference

8 February 2021

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PubMed publication ID

1

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12 March 2020

Anthony P Davenport

series ordinal

2

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12 March 2020

author name string

A P Davenport

series ordinal

2

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language of work or name

English

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publication date

24 November 2014

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British Journal of Pharmacology

12 March 2020

1 December 2014

3 references

14 September 2020

3 December 2020

8 February 2021

11 references

22 March 2019

3 April 2019

31 July 2019

28 September 2019

2 October 2019

20 November 2019

15 December 2019

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12 March 2020

14 September 2020

3 December 2020

8 February 2021

171

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12 March 2020

issue

24

1 reference

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12 March 2020

page(s)

5555-5572

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Creative Commons Attribution 3.0 Unported

12 March 2020

copyright license

10 references

22 March 2019

3 April 2019

31 July 2019

28 September 2019

2 October 2019

20 November 2019

15 December 2019

14 September 2020

3 December 2020

on focus list of Wikimedia project

8 February 2021

copyright status

copyrighted

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ScienceSource

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Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1

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Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

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Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization

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Vasoconstrictor activity of novel endothelin peptide, ET-1(1 - 31), in human mammary and coronary arteries in vitro

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Proteolytic processing of big endothelin-3 by the kell blood group protein

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Evidence for intracellular endothelin-converting enzyme-2 expression in cultured human vascular endothelial cells

20 March 2017

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Blockade and reversal of endothelin-induced constriction in pial arteries from human brain

20 March 2017

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Human endothelial cell storage granules: a novel intracellular site for isoforms of the endothelin-converting enzyme

20 March 2017

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Endothelin converting enzyme (ECE) activity in human vascular smooth muscle

20 March 2017

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Characterization of the binding of endothelin ETB selective ligands in human and rat heart

20 March 2017

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ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

20 March 2017

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Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

20 March 2017

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The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes

20 March 2017

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Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development

20 March 2017

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Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice

20 March 2017

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Endothelin-2 in ovarian follicle rupture

20 March 2017

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Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice

20 March 2017

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20 March 2017

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29 September 2017

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29 September 2017

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β-arrestin-1 drives endothelin-1-mediated podocyte activation and sustains renal injury

29 September 2017

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29 September 2017

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Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis

29 September 2017

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Endothelin 1 in cancer: biological implications and therapeutic opportunities

29 September 2017

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Physiology of endothelin and the kidney

29 September 2017

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Endothelin, kidney disease, and hypertension

29 September 2017

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Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration

29 September 2017

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Epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat: epigenetics in PAH following IUGR.

29 September 2017

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Interaction profile of macitentan, a new non-selective endothelin-1 receptor antagonist, in vitro

29 September 2017

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Endothelin-converting enzymes degrade intracellular β-amyloid produced within the endosomal/lysosomal pathway and autophagosomes.

29 September 2017

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Generation and characterization of rendomab-B1, a monoclonal antibody displaying potent and specific antagonism of the human endothelin B receptor

29 September 2017

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Nitric oxide and the A and B of endothelin of sodium homeostasis.

29 September 2017

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Clinical trials with endothelin receptor antagonists: what went wrong and where can we improve?

29 September 2017

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The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth.

29 September 2017

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Endothelin receptor antagonists for the treatment of pulmonary artery hypertension

29 September 2017

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Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer

29 September 2017

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Pathophysiological roles of endothelin receptors in cardiovascular diseases

29 September 2017

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Permissive role of endothelin receptors in tumor metastasis

29 September 2017

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Why two endothelins and two receptors for ovulation and luteal regulation?

29 September 2017

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Endothelin-1 and the kidney--beyond BP.

29 September 2017

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New perspectives on endothelin-1 in atherosclerosis and diabetes mellitus

29 September 2017

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Place your BETs: the therapeutic potential of bromodomains

29 September 2017

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Endothelin in hypertension: an update

29 September 2017

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Early progress in epigenetic regulation of endothelin pathway genes

29 September 2017

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Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist

29 September 2017

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Endothelin-2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer.

29 September 2017

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Endothelin antagonism in patients with nondiabetic chronic kidney disease

29 September 2017

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Novel therapy approach in primary stroke prevention: simultaneous inhibition of endothelin converting enzyme and neutral endopeptidase in spontaneously hypertensive, stroke-prone rats improves survival

29 September 2017

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Macitentan: entry-into-humans study with a new endothelin receptor antagonist

29 September 2017

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Regulation of blood pressure and salt homeostasis by endothelin

29 September 2017

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Role of the endothelin axis and its antagonists in the treatment of cancer

29 September 2017

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Positron emission tomography of [18F]-big endothelin-1 reveals renal excretion but tissue-specific conversion to [18F]-endothelin-1 in lung and liver

29 September 2017

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Endothelin receptor antagonists: status and learning 20 years on.

29 September 2017

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Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis

29 September 2017

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Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist

29 September 2017

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Endothelin-1 (1-31): from chymase-dependent synthesis to cardiovascular pathologies.

29 September 2017

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The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house?

29 September 2017

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Clinical trials of endothelin antagonists in heart failure: a question of dose?

29 September 2017

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International Union of Pharmacology. XLVI. G protein-coupled receptor list.

29 September 2017

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Endothelin-1-induced vasodilatation in rat breast tumor is mediated through endothelin-B receptors

29 September 2017

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Sitaxsentan therapy for pulmonary arterial hypertension

29 September 2017

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Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications

29 September 2017

1 reference

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Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

29 September 2017

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The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function

29 September 2017

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Contraction to big endothelin-1, big endothelin-2 and big endothelin-3, and endothelin-converting enzyme inhibition in human isolated bronchi

29 September 2017

1 reference

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Expression of endothelin-1, endothelin-converting enzyme, and endothelin receptors in chronic heart failure

29 September 2017

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Secretory pathways in endothelin synthesis.

29 September 2017

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Increased response to big endothelin-1 in atherosclerotic human coronary artery: functional evidence for up-regulation of endothelin-converting enzyme activity in disease.

29 September 2017

1 reference

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Endothelin B receptors on human endothelial and smooth-muscle cells show equivalent binding pharmacology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Evidence using immunoelectron microscopy for regulated and constitutive pathways in the transport and release of endothelin.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Molecular pharmacology of endothelin converting enzymes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Pharmacological characterization of PD 156707, an orally active ETA receptor antagonist

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Sarafotoxins S6: several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Endothelins are more sensitive than sarafotoxins to neutral endopeptidase: possible physiological significance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Characterization of two new ETB selective radioligands, [125I]-BQ3020 and [125I]-[Ala1,3,11,15]ET-1 in human heart

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Contributions of degradation and brain-to-blood elimination across the blood-brain barrier to cerebral clearance of human amyloid-β peptide(1-40) in mouse brain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Endothelin-1 and endothelin-2 initiate and maintain contractile responses by different mechanisms in rat mesenteric and cerebral arteries

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Pharmacokinetics of macitentan in caucasian and Japanese subjects: the influence of ethnicity and sex.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Dual endothelin-converting enzyme/neutral endopeptidase blockade in rats with D-galactosamine-induced liver failure

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Expression of endothelin(A) receptors in human gliomas and meningiomas, with high affinity for the selective antagonist PD156707.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Analysis of two pharmacologically predicted endothelin B receptor subtypes by using the endothelin B receptor gene knockout mouse

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

The increase in human plasma immunoreactive endothelin but not big endothelin-1 or its C-terminal fragment induced by systemic administration of the endothelin antagonist TAK-044.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Characterization of the endothelin receptor selective agonist, BQ3020 and antagonists BQ123, FR139317, BQ788, 50235, Ro462005 and bosentan in the heart.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Alternatively spliced mRNAs for human endothelin-2 and their tissue distribution

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Species differences in the binding characteristics of [125I]IRL-1620, a potent agonist specific for endothelin-B receptors

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Cloning and expression of a cDNA encoding an endothelin receptor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Topographical localisation of endothelin mRNA and peptide immunoreactivity in neurones of the human brain

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Sarafotoxin S6c: An agonist which distinguishes between endothelin receptor subtypes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Endothelin-1-induced vasoconstriction in humans. Reversal by calcium channel blockade but not by nitrovasodilators or endothelium-derived relaxing factor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Localization of immunoreactive endothelin and proendothelin in the human lung

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Cerebellar neurons and glia respond differentially to endothelins and sarafotoxin S6b.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage

2 June 2018

1 reference

Endothelin receptor type B agonist, IRL-1620, prevents beta amyloid (Aβ) induced oxidative stress and cognitive impairment in normal and diabetic rats.

21 January 2018

1 reference

Effect of single doses of SLV306, an inhibitor of both neutral endopeptidase and endothelin-converting enzyme, on pulmonary pressures in congestive heart failure

21 January 2018

1 reference

Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.

21 January 2018

1 reference

Endothelin-1 (1-31) is an intermediate in the production of endothelin-1 after big endothelin-1 administration in vivo

21 January 2018

1 reference

Reduced endogenous endothelin-1-mediated vascular tone in chronic renal failure.

21 January 2018

1 reference

Molecular isolation and characterization of novel four subisoforms of ECE-2.

21 January 2018

1 reference

Endothelial cell-specific ETB receptor knockout: autoradiographic and histological characterisation and crucial role in the clearance of endothelin-1.

21 January 2018

1 reference

Maternal dexamethasone increases endothelin-1 sensitivity and endothelin a receptor expression in ovine foetal placental arteries

21 January 2018

1 reference

Endothelin B receptor agonist, IRL-1620, enhances angiogenesis and neurogenesis following cerebral ischemia in rats

21 January 2018

1 reference

Endothelin B receptor agonist, IRL-1620, reduces neurological damage following permanent middle cerebral artery occlusion in rats.

21 January 2018

1 reference

Endothelin B receptor agonist, IRL-1620, provides long-term neuroprotection in cerebral ischemia in rats.

21 January 2018

1 reference

Alternative pathway to endothelin-converting enzyme for the synthesis of endothelin in human blood vessels

21 January 2018

1 reference

Comparison of human ETA and ETB receptor signalling via G-protein and β-arrestin pathways

21 January 2018

1 reference

A novel pathway involving progesterone receptor, endothelin-2, and endothelin receptor B controls ovulation in mice.

21 January 2018

1 reference

Effect on blood pressure of combined inhibition of endothelin-converting enzyme and neutral endopeptidase with daglutril in patients with type 2 diabetes who have albuminuria: a randomised, crossover, double-blind, placebo-controlled trial

21 January 2018

1 reference

Macitentan and morbidity and mortality in pulmonary arterial hypertension

21 January 2018

1 reference

Endothelin B receptor agonist, IRL 1620, enhances the anti-tumor efficacy of paclitaxel in breast tumor rats

21 January 2018

1 reference

β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling.

21 January 2018

1 reference

The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans

21 January 2018

1 reference

Differential expression of endothelin-2 along the mouse intestinal tract

21 January 2018

1 reference

Inhibition of both neutral endopeptidase and endothelin-converting enzyme by SLV306 reduces proteinuria and urinary albumin excretion in diabetic rats

21 January 2018

1 reference

Deletion of Endothelial Cell Endothelin B Receptors Does Not Affect Blood Pressure or Sensitivity to Salt

21 January 2018

1 reference

Absorption, distribution, metabolism, and excretion of macitentan, a dual endothelin receptor antagonist, in humans

21 January 2018

1 reference

A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: comparison of levels in patients with essential hypertension and normotensive control subjects

21 January 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

21 January 2018

Anatomical localization and pharmacological activity of mature endothelins and their precursors in human vascular tissue

27 November 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

21 January 2018

Localization of endothelin peptides in human kidney

27 November 2018

1 reference

Endothelin receptor antagonism in patients with chronic heart failure

21 January 2018

1 reference

Characterization and localization of endothelin receptor subtypes in the human atrioventricular conducting system and myocardium

21 January 2018

2 references

21 January 2018

12 December 2020

Expression of endothelin peptides and mRNA in the human heart

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

21 January 2018

Endothelin-Converting Enzyme/Neutral Endopeptidase Inhibitor SLV338 Prevents Hypertensive Cardiac Remodeling in a Blood Pressure–Independent Manner

27 November 2018

1 reference

Contribution of endogenous generation of endothelin-1 to basal vascular tone

21 January 2018

1 reference

Safety, tolerability, pharmacokinetics, and pharmacodynamics of macitentan, an endothelin receptor antagonist, in an ascending multiple-dose study in healthy subjects

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Effect of in vivo fetal infusion of dexamethasone at 0.75 GA on fetal ovine resistance artery responses to ET-1.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Characterization of endothelin receptors in human brain cortex, gliomas, and meningiomas

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Delineation of endothelin receptors in human left ventricular smooth-muscle cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Endogenous endothelin generation maintains vascular tone in humans.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4290702

Effect of the ET(B) receptor agonist, IRL-1620, on paclitaxel plasma pharmacokinetics of breast tumor rats

27 November 2018

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic properties of SOL1: a novel dual inhibitor of neutral endopeptidase and endothelin converting enzyme

1 reference

12 December 2020

Renoprotective effects of combined endothelin-converting enzyme/neutral endopeptidase inhibitor SLV338 in acute and chronic experimental renal damage

1 reference

12 December 2020

IRL-1620, an endothelin-B receptor agonist, enhanced radiation induced reduction in tumor volume in Dalton's Lymphoma Ascites tumor model

1 reference

12 December 2020

Relaxation of human temporal artery by endothelin ETB receptors

1 reference

12 December 2020

Novel selective quinazoline inhibitors of endothelin converting enzyme-1

1 reference

12 December 2020

Ironic case of hepatic dysfunction following the global withdrawal of sitaxentan

1 reference

12 December 2020

Pharmacokinetics of the novel dual endothelin receptor antagonist macitentan in subjects with hepatic or renal impairment

1 reference

12 December 2020

Regulation and intracellular trafficking pathways of the endothelin receptors

1 reference

12 December 2020

Bosentan therapy for pulmonary arterial hypertension

1 reference

12 December 2020

Regional and maturation-associated expression of endothelin 2 in rat gastrointestinal tract

1 reference

12 December 2020

Endothelin-A receptors mediate contraction in human cerebral, meningeal and temporal arteries

1 reference

12 December 2020

Are there different ETB receptors mediating constriction and relaxation?

1 reference

12 December 2020

Lack of biological activity of preproendothelin [110-130] in several endothelin assays

1 reference

12 December 2020

Pharmacological profile of a non-peptidic dual inhibitor of neutral endopeptidase 24.11 and endothelin-converting enzyme

1 reference

12 December 2020

Identifiers

DOI

10.1111/BPH.12874

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25131455%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25131455%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

25131455

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25131455%20AND%20SRC:MED&resulttype=core&format=json