Cytoplasmic DNA innate immune pathways (Q28246926)

Plant and animal sensors of conserved microbial signatures

Europe PubMed Central

title

Cytoplasmic DNA innate immune pathways (English)

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author name string

Glen N Barber

series ordinal

1

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language of work or name

English

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publication date

September 2011

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published in

Immunological Reviews

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volume

243

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page(s)

99-108

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issue

1

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cites work

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An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

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Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

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Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

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Regulation of immunity and oncogenesis by the IRF transcription factor family

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IRF-7 is the master regulator of type-I interferon-dependent immune responses

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Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases.

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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

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A FADD-dependent innate immune mechanism in mammalian cells

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

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LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

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Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

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VISA is an adapter protein required for virus-triggered IFN-beta signaling

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Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells

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Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathways

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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

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The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

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UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

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Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3

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Compartment-specific control of signaling from a DNA-sensing immune receptor.

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Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice

21 January 2018

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Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells

21 January 2018

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Innate immune control of nucleic acid-based vaccine immunogenicity

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Immune mechanisms and therapeutic potential of CpG oligodeoxynucleotides

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TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE.

21 January 2018

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Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

21 January 2018

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Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

21 January 2018

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A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

21 January 2018

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

21 January 2018

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The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

21 January 2018

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ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

21 January 2018

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Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.

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A tetrameric complex of membrane proteins in the endoplasmic reticulum

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Single Copies of Sec61 and TRAP Associate with a Nontranslating Mammalian Ribosome

21 January 2018

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Protein targeting by the signal recognition particle.

21 January 2018

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ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER.

21 January 2018

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Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease

21 January 2018

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The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.

21 January 2018

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TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders

21 January 2018

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Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

21 January 2018

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Retrograde transport pathways utilised by viruses and protein toxins

21 January 2018

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The exocyst meets the translocon: a regulatory circuit for secretion and protein synthesis?

21 January 2018

1 reference

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RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival

21 January 2018

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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

21 January 2018

1 reference

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The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01051.X

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01051.X

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides

21 January 2018

1 reference

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Identification and characterization of a loss-of-function human MPYS variant

21 January 2018

1 reference

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Cellular reactive oxygen species inhibit MPYS induction of IFNβ

21 January 2018

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MAM: more than just a housekeeper

21 January 2018

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TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

21 January 2018

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TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections.

21 January 2018

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Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01051.X

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01051.X

Trex1 prevents cell-intrinsic initiation of autoimmunity

21 January 2018

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The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1.

21 January 2018

1 reference

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The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01051.X

The inflammasome NLRs in immunity, inflammation, and associated diseases

21 January 2018

1 reference

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Sensing pathogens and danger signals by the inflammasome

21 January 2018

1 reference

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RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01051.X

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01051.X

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01051.X

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01051.X

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01051.X

Architecture of the Ribosome–Channel Complex Derived from Native Membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01051.X

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01051.X

10.1111/J.1600-065X.2011.01051.X

21 January 2018

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

911687

911687

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference