mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR (Q28251026)

2

Hiroyuki Inuzuka

0 references

Wenyi Wei

17

Wenyi Wei

0 references

Lixin Wan

7

Lixin Wan

0 references

Shavali Shaik

10

Shavali Shaik

0 references

Hidefumi Fukushima

4

Hidefumi Fukushima

0 references

author name string

Daming Gao

1

0 references

Meng-Kwang Marcus Tan

3

0 references

Jason W Locasale

5

0 references

Pengda Liu

6

0 references

Bo Zhai

8

0 references

Y Rebecca Chin

9

0 references

Costas A Lyssiotis

11

0 references

Steven P Gygi

12

0 references

Alex Toker

13

0 references

Lewis C Cantley

14

0 references

J Wade Harper

mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR

16

0 references

language of work or name

English

0 references

publication date

21 October 2011

0 references

published in

Molecular Cell

0 references

volume

44

0 references

issue

2

0 references

page(s)

290-303

0 references

cites work

1 reference

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20 March 2017

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Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

20 March 2017

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Network organization of the human autophagy system

20 March 2017

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

20 March 2017

1 reference

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DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

20 March 2017

1 reference

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Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

20 March 2017

1 reference

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

20 March 2017

1 reference

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

20 March 2017

1 reference

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

20 March 2017

1 reference

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Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

20 March 2017

1 reference

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

20 March 2017

1 reference

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The DNA damage response: ten years after

20 March 2017

1 reference

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Defining the role of mTOR in cancer

20 March 2017

1 reference

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AKT/PKB signaling: navigating downstream

20 March 2017

1 reference

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

20 March 2017

1 reference

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

20 March 2017

1 reference

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

20 March 2017

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

20 March 2017

1 reference

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The SCF ubiquitin ligase: insights into a molecular machine

20 March 2017

1 reference

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Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

20 March 2017

1 reference

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Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

20 March 2017

1 reference

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

20 March 2017

1 reference

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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

20 March 2017

1 reference

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Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

20 March 2017

1 reference

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

7 April 2017

1 reference

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

7 April 2017

1 reference

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mTOR and cancer: insights into a complex relationship

7 April 2017

1 reference

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mTOR and cancer: many loops in one pathway.

7 April 2017

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Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways

29 September 2017

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mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase

29 September 2017

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29 September 2017

Expanding mTOR signaling

1 reference

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Stress and mTORture signaling

29 September 2017

1 reference

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Transformation of human and murine fibroblasts without viral oncoproteins

29 September 2017

1 reference

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Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply

29 September 2017

1 reference

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New insights into mTOR signaling: mTORC2 and beyond

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229299

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229299

Coordinate expression of the PI3-kinase downstream effectors serum and glucocorticoid-induced kinase (SGK-1) and Akt-1 in human breast cancer

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22017875

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2011.08.030

1 reference

release_wer7tgf6nncqdodqgh3oc7edea

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/wer7tgf6nncqdodqgh3oc7edea

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

1 reference

PubMed publication ID

22017875

1 reference