mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR (Q28251047)

2

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Shafi Kuchay

3

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Alfredo Toschi

4

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Naama Kanarek

5

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Yinon Ben-Neriah

6

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Michele Pagano

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR

7

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language of work or name

English

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publication date

21 October 2011

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published in

Molecular Cell

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volume

44

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issue

2

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page(s)

317-24

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cites work

1 reference

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mTOR: from growth signal integration to cancer, diabetes and ageing

20 March 2017

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DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

20 March 2017

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betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis

20 March 2017

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Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

20 March 2017

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Control of chromosome stability by the beta-TrCP-REST-Mad2 axis

20 March 2017

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Defining the role of mTOR in cancer

20 March 2017

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S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

20 March 2017

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SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

20 March 2017

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Systematic analysis and nomenclature of mammalian F-box proteins

20 March 2017

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The SCF ubiquitin ligase: insights into a molecular machine

20 March 2017

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A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteins

20 March 2017

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Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

20 March 2017

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Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100

20 March 2017

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Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination

20 March 2017

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Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

20 March 2017

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mTOR signaling at a glance

7 April 2017

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mTOR signaling and drug development in cancer

7 April 2017

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Identification of SCF ubiquitin ligase substrates by global protein stability profiling

29 September 2017

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The age of crosstalk: phosphorylation, ubiquitination, and beyond

29 September 2017

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Large-scale phosphorylation analysis of mouse liver

29 September 2017

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The Akt-mTOR tango and its relevance to cancer

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High-resolution array comparative genomic hybridization of chromosome arm 8q: evaluation of genetic progression markers for prostate cancer.

29 September 2017

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Construction and application of a full-coverage, high-resolution, human chromosome 8q genomic microarray for comparative genomic hybridization

29 September 2017

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Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2.

29 September 2017

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In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation

29 September 2017

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Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers.

29 September 2017

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High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients

27 November 2018

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10.1016/J.MOLCEL.2011.09.005

27 November 2018

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

22017877

1 reference